The value-added genome: building and maintaining genomic cytosine methylation landscapes

Epigenetic marks, such as cytosine methylation and post-translational histone modifications, are important for interpreting and managing eukaryotic genomes. Recent genetic studies in plants have uncovered details on the different interwoven mechanisms that are responsible for specification of genomi...

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Vydáno v:Current opinion in genetics & development Ročník 14; číslo 6; s. 686 - 691
Hlavní autoři: Rangwala, Sanjida H, Richards, Eric J
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.12.2004
Témata:
Arabidopsis
Arabidopsis - genetics
Arabidopsis - metabolism
Cytosine
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA Methylation
DNA Transposable Elements
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Epigenesis, Genetic
Genome
Heterochromatin
Histones
siRNA
5mC
RdDM
H3mK9
ISSN:0959-437X, 1879-0380
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Shrnutí:Epigenetic marks, such as cytosine methylation and post-translational histone modifications, are important for interpreting and managing eukaryotic genomes. Recent genetic studies in plants have uncovered details on the different interwoven mechanisms that are responsible for specification of genomic cytosine methylation patterns. These mechanisms include targeting cytosine methylation using heterochromatic histone modifications and RNA guides. Genomic cytosine methylation patterns also reflect locus-specific demethylation initiated by specialized DNA glycosylases. While genetics continues to more fully define these mechanisms, genomic studies in Arabidopsis have yielded an unprecedented high-resolution view of how epigenetic marks are layered over a genome.
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ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2004.09.009