Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emergin...

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Vydáno v:	JCI insight Ročník 5; číslo 12
Hlavní autoři:	Karki, Rajendra, Sharma, Bhesh Raj, Lee, Ein, Banoth, Balaji, Malireddi, R.K. Subbarao, Samir, Parimal, Tuladhar, Shraddha, Mummareddy, Harisankeerth, Burton, Amanda R., Vogel, Peter, Kanneganti, Thirumala-Devi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Society for Clinical Investigation 18.06.2020
Témata:	Apoptosis Cancer Cell death Colitis Colorectal cancer Colorectal carcinoma Homeostasis Infections Inflammasomes Inflammation Inflammatory bowel disease Inflammatory diseases Interferon Interferon regulatory factor Interferon regulatory factor 1 Kinases Medical prognosis Mutation Necroptosis Proteins Pyroptosis Transcription factors Tumorigenesis Tumors Innate immunity Oncology Immunology Colorectal cancer Cancer
ISSN:	2379-3708, 2379-3708
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Abstract	Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not clear. Here, we found that mice lacking IRF1 were hypersusceptible to colorectal tumorigenesis. IRF1 functions in both the myeloid and epithelial compartments to confer protection against AOM/DSS-induced colorectal tumorigenesis. We further found that IRF1 also prevents tumorigenesis in a spontaneous mouse model of colorectal cancer. The attenuated cell death in the colons of Irf1-/- mice was due to defective pyroptosis, apoptosis, and necroptosis (PANoptosis). IRF1 does not regulate inflammation and the inflammasome in the colon. Overall, our study identified IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis.
AbstractList	Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not clear. Here, we found that mice lacking IRF1 were hypersusceptible to colorectal tumorigenesis. IRF1 functions in both the myeloid and epithelial compartments to confer protection against AOM/DSS-induced colorectal tumorigenesis. We further found that IRF1 also prevents tumorigenesis in a spontaneous mouse model of colorectal cancer. The attenuated cell death in the colons of Irf1-/- mice was due to defective pyroptosis, apoptosis, and necroptosis (PANoptosis). IRF1 does not regulate inflammation and the inflammasome in the colon. Overall, our study identified IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis.Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not clear. Here, we found that mice lacking IRF1 were hypersusceptible to colorectal tumorigenesis. IRF1 functions in both the myeloid and epithelial compartments to confer protection against AOM/DSS-induced colorectal tumorigenesis. We further found that IRF1 also prevents tumorigenesis in a spontaneous mouse model of colorectal cancer. The attenuated cell death in the colons of Irf1-/- mice was due to defective pyroptosis, apoptosis, and necroptosis (PANoptosis). IRF1 does not regulate inflammation and the inflammasome in the colon. Overall, our study identified IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis. Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not clear. Here, we found that mice lacking IRF1 were hypersusceptible to colorectal tumorigenesis. IRF1 functions in both the myeloid and epithelial compartments to confer protection against AOM/DSS-induced colorectal tumorigenesis. We further found that IRF1 also prevents tumorigenesis in a spontaneous mouse model of colorectal cancer. The attenuated cell death in the colons of Irf1–/– mice was due to defective pyroptosis, apoptosis, and necroptosis (PANoptosis). IRF1 does not regulate inflammation and the inflammasome in the colon. Overall, our study identified IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis. IRF1-deficient mice are hypersusceptible to colorectal tumorigenesis, with attenuated cell death in the colons caused by defective PANoptosis. Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not clear. Here, we found that mice lacking IRF1 were hypersusceptible to colorectal tumorigenesis. IRF1 functions in both the myeloid and epithelial compartments to confer protection against AOM/DSS-induced colorectal tumorigenesis. We further found that IRF1 also prevents tumorigenesis in a spontaneous mouse model of colorectal cancer. The attenuated cell death in the colons of Irf1–/– mice was due to defective pyroptosis, apoptosis, and necroptosis (PANoptosis). IRF1 does not regulate inflammation and the inflammasome in the colon. Overall, our study identified IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis.
Author	Banoth, Balaji Malireddi, R.K. Subbarao Kanneganti, Thirumala-Devi Burton, Amanda R. Vogel, Peter Samir, Parimal Lee, Ein Karki, Rajendra Tuladhar, Shraddha Sharma, Bhesh Raj Mummareddy, Harisankeerth
AuthorAffiliation	4 Animal Resources Center and Veterinary Pathology Core, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA 2 Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, Tennessee, USA 1 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA 3 Emory College of Arts and Sciences, Emory University, Atlanta, Georgia, USA
AuthorAffiliation_xml	– name: 2 Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, Tennessee, USA – name: 4 Animal Resources Center and Veterinary Pathology Core, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA – name: 1 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA – name: 3 Emory College of Arts and Sciences, Emory University, Atlanta, Georgia, USA
Author_xml	– sequence: 1 givenname: Rajendra surname: Karki fullname: Karki, Rajendra – sequence: 2 givenname: Bhesh Raj surname: Sharma fullname: Sharma, Bhesh Raj – sequence: 3 givenname: Ein surname: Lee fullname: Lee, Ein – sequence: 4 givenname: Balaji surname: Banoth fullname: Banoth, Balaji – sequence: 5 givenname: R.K. Subbarao surname: Malireddi fullname: Malireddi, R.K. Subbarao – sequence: 6 givenname: Parimal surname: Samir fullname: Samir, Parimal – sequence: 7 givenname: Shraddha surname: Tuladhar fullname: Tuladhar, Shraddha – sequence: 8 givenname: Harisankeerth surname: Mummareddy fullname: Mummareddy, Harisankeerth – sequence: 9 givenname: Amanda R. surname: Burton fullname: Burton, Amanda R. – sequence: 10 givenname: Peter orcidid: 0000-0002-7535-0545 surname: Vogel fullname: Vogel, Peter – sequence: 11 givenname: Thirumala-Devi surname: Kanneganti fullname: Kanneganti, Thirumala-Devi
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32554929$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1053/gast.1996.v110.pm8536888 10.1126/sciimmunol.aag2045 10.1038/cddis.2015.20 10.1089/107999002753452647 10.1002/med.21398 10.1016/j.semcancer.2015.03.001 10.1038/nrm2970 10.1038/nature20597 10.1038/s41564-018-0298-0 10.1038/nature13788 10.1073/pnas.86.24.9936 10.1084/jem.20171922 10.1016/j.critrevonc.2005.06.005 10.3389/fcimb.2019.00406 10.1038/cdd.2016.8 10.1016/j.cancergencyto.2006.12.008 10.1016/S1074-7613(00)80527-0 10.1126/science.7510419 10.1126/scisignal.aax4917 10.1038/sj.onc.1210470 10.1093/carcin/bgi113 10.1158/2326-6066.CIR-16-0269 10.1006/jaut.2001.0531 10.3892/ol.2012.1051 10.1126/science.1260419 10.1126/science.aan2507 10.1038/s41418-018-0159-7 10.1053/j.gastro.2016.11.049 10.4049/jimmunol.1002046 10.15252/embr.201948891 10.1046/j.1365-2141.2002.03829.x 10.4049/jimmunol.1302839 10.1093/intimm/dxg086 10.1038/nrc.2016.54 10.1158/0008-5472.CAN-04-2223 10.1615/CritRevOncog.2016016976 10.1126/science.281.5381.1309 10.1038/s41419-019-1883-8 10.1126/science.1249361 10.1016/j.cell.2015.06.001 10.1038/s41568-019-0123-y 10.1038/382816a0 10.1158/1078-0432.CCR-06-2191 10.1038/cr.2013.171 10.1002/jcb.10142 10.1038/cdd.2009.156 10.1038/ni.3118 10.1038/sj.onc.1207023 10.1016/j.tranon.2019.04.010 10.1038/nature15541 10.1084/jem.20160442 10.1016/j.chembiol.2017.03.009 10.1083/jcb.200303157 10.1016/j.cell.2020.03.040 10.1002/jcb.21707 10.1074/jbc.273.12.7141
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Keywords	Innate immunity Oncology Immunology Colorectal cancer Cancer
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References	B20 B21 B23 B24 B25 B26 B27 B28 B29 Malireddi (B30) 2019; 9 Labi (B40) 2015; 6 B31 B32 B33 B34 B35 B36 B37 B38 B39 B1 B2 B3 B4 B5 B6 B7 B8 B9 Mohammad (B22) 2015; 35 Suppl Thygesen (B42) 2019; 20 B41 B43 B44 B45 B46 Harada (B50) 1994; 9 B47 B48 B49 B51 B52 B53 B10 B54 B11 B55 B12 B56 B13 B57 B14 B58 B15 B59 B16 B17 B18 Tamura (B19) 1996; 56
References_xml	– ident: B18 doi: 10.1053/gast.1996.v110.pm8536888 – ident: B7 doi: 10.1126/sciimmunol.aag2045 – volume: 6 year: 2015 ident: B40 article-title: How cell death shapes cancer publication-title: Cell Death Dis doi: 10.1038/cddis.2015.20 – ident: B12 doi: 10.1089/107999002753452647 – ident: B46 doi: 10.1002/med.21398 – volume: 56 start-page: 612 issue: 3 year: 1996 ident: B19 article-title: Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach publication-title: Cancer Res – volume: 35 Suppl start-page: S78 year: 2015 ident: B22 article-title: Broad targeting of resistance to apoptosis in cancer publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2015.03.001 – ident: B25 doi: 10.1038/nrm2970 – ident: B35 doi: 10.1038/nature20597 – ident: B8 doi: 10.1038/s41564-018-0298-0 – ident: B21 – ident: B32 doi: 10.1038/nature13788 – ident: B1 doi: 10.1073/pnas.86.24.9936 – ident: B29 doi: 10.1084/jem.20171922 – ident: B37 doi: 10.1016/j.critrevonc.2005.06.005 – volume: 9 year: 2019 ident: B30 article-title: ZBP1 and TAK1: master regulators of nlrp3 inflammasome/pyroptosis, apoptosis, and necroptosis (PAN-optosis) publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2019.00406 – ident: B44 doi: 10.1038/cdd.2016.8 – ident: B20 doi: 10.1016/j.cancergencyto.2006.12.008 – ident: B36 doi: 10.1016/S1074-7613(00)80527-0 – ident: B2 doi: 10.1126/science.7510419 – ident: B43 doi: 10.1126/scisignal.aax4917 – ident: B47 doi: 10.1038/sj.onc.1210470 – ident: B3 doi: 10.1093/carcin/bgi113 – ident: B9 doi: 10.1158/2326-6066.CIR-16-0269 – ident: B5 doi: 10.1006/jaut.2001.0531 – ident: B17 doi: 10.3892/ol.2012.1051 – ident: B59 doi: 10.1126/science.1260419 – ident: B58 doi: 10.1126/science.aan2507 – volume: 9 start-page: 3313 issue: 11 year: 1994 ident: B50 article-title: Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation publication-title: Oncogene – ident: B57 doi: 10.1038/s41418-018-0159-7 – ident: B53 doi: 10.1053/j.gastro.2016.11.049 – ident: B55 doi: 10.4049/jimmunol.1002046 – volume: 20 issue: 9 year: 2019 ident: B42 article-title: IRF1 and IRF2 regulate the non-canonical inflammasome publication-title: EMBO Rep doi: 10.15252/embr.201948891 – ident: B51 doi: 10.1046/j.1365-2141.2002.03829.x – ident: B27 doi: 10.4049/jimmunol.1302839 – ident: B6 doi: 10.1093/intimm/dxg086 – ident: B56 doi: 10.1038/nrc.2016.54 – ident: B14 doi: 10.1158/0008-5472.CAN-04-2223 – ident: B39 doi: 10.1615/CritRevOncog.2016016976 – ident: B45 doi: 10.1126/science.281.5381.1309 – ident: B33 doi: 10.1038/s41419-019-1883-8 – ident: B26 doi: 10.1126/science.1249361 – ident: B54 doi: 10.1016/j.cell.2015.06.001 – ident: B10 doi: 10.1038/s41568-019-0123-y – ident: B11 doi: 10.1038/382816a0 – ident: B52 doi: 10.1158/1078-0432.CCR-06-2191 – ident: B24 doi: 10.1038/cr.2013.171 – ident: B13 doi: 10.1002/jcb.10142 – ident: B15 doi: 10.1038/cdd.2009.156 – ident: B4 doi: 10.1038/ni.3118 – ident: B16 doi: 10.1038/sj.onc.1207023 – ident: B41 doi: 10.1016/j.tranon.2019.04.010 – ident: B23 doi: 10.1038/nature15541 – ident: B34 doi: 10.1084/jem.20160442 – ident: B28 doi: 10.1016/j.chembiol.2017.03.009 – ident: B48 doi: 10.1083/jcb.200303157 – ident: B31 doi: 10.1016/j.cell.2020.03.040 – ident: B38 doi: 10.1002/jcb.21707 – ident: B49 doi: 10.1074/jbc.273.12.7141
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Snippet	Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic...
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SubjectTerms	Apoptosis Cancer Cell death Colitis Colorectal cancer Colorectal carcinoma Homeostasis Infections Inflammasomes Inflammation Inflammatory bowel disease Inflammatory diseases Interferon Interferon regulatory factor Interferon regulatory factor 1 Kinases Medical prognosis Mutation Necroptosis Proteins Pyroptosis Transcription factors Tumorigenesis Tumors
Title	Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer
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