Augmented Lipocalin-2 Is Associated with Chronic Obstructive Pulmonary Disease and Counteracts Lung Adenocarcinoma Development

Early pathogenesis of lung adenocarcinoma (LUAD) remains largely unknown. We found that, relative to wild-type littermates, the innate immunomodulator (lipocalin-2) was increased in normal airways from mice with knockout of the airway lineage gene ( ) and that are prone to developing inflammation an...

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Vydáno v:	American journal of respiratory and critical care medicine Ročník 203; číslo 1; s. 90
Hlavní autoři:	Treekitkarnmongkol, Warapen, Hassane, Maya, Sinjab, Ansam, Chang, Kyle, Hara, Kieko, Rahal, Zahraa, Zhang, Jiexin, Lu, Wei, Sivakumar, Smruthy, McDowell, Tina L, Kantrowitz, Jacob, Zhou, Jianling, Lang, Wenhua, Xu, Li, Ochieng, Joshua K, Nunomura-Nakamura, Sayuri, Deng, Shanshan, Behrens, Carmen, Raso, Maria Gabriela, Fukuoka, Junya, Reuben, Alexandre, Ostrin, Edwin J, Parra, Edwin, Solis, Luisa M, Spira, Avrum E, McAllister, Florencia, Cascone, Tina, Wistuba, Ignacio I, Moghaddam, Seyed Javad, Scheet, Paul A, Fujimoto, Junya, Kadara, Humam
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2021
Témata:	Adenocarcinoma of Lung - immunology Animals Antineoplastic Agents - immunology Biomarkers - blood Female Gene Expression Regulation Humans Lipocalin-2 - blood Lipocalin-2 - genetics Lipocalin-2 - immunology Lung Neoplasms - immunology Male Mice Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - physiopathology RNA, Messenger immunity lung neoplasms lipocalin-2 chronic obstructive pulmonary disease
ISSN:	1535-4970, 1535-4970
On-line přístup:	Zjistit podrobnosti o přístupu
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