IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential component of the TME, contributing to tumorigenesis...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 78; no. 17; p. 4957
Main Authors:	Karakasheva, Tatiana A, Lin, Eric W, Tang, Qiaosi, Qiao, Edmund, Waldron, Todd J, Soni, Monica, Klein-Szanto, Andres J, Sahu, Varun, Basu, Devraj, Ohashi, Shinya, Baba, Kiichiro, Giaccone, Zachary T, Walker, Sarah R, Frank, David A, Wileyto, E Paul, Long, Qi, Dunagin, Margaret C, Raj, Arjun, Diehl, J Alan, Wong, K K, Bass, Adam J, Rustgi, Anil K
Format:	Journal Article
Language:	English
Published:	United States 01.09.2018
Subjects:	Animals Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Carcinogenesis - genetics Cell Line, Tumor Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - pathology Humans Interleukin-6 - genetics MAP Kinase Signaling System - genetics Mice Receptors, Interleukin-6 - genetics Signal Transduction STAT3 Transcription Factor - genetics Tumor Microenvironment - genetics Xenograft Model Antitumor Assays
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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