Aging‐related histone modification changes in brain function
Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving ne...
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| Veröffentlicht in: | Ibrain Jg. 9; H. 2; S. 205 - 213 |
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| Sprache: | Englisch |
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John Wiley & Sons, Inc
01.06.2023
John Wiley and Sons Inc Wiley-VCH |
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| ISSN: | 2769-2795, 2313-1934, 2769-2795 |
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| Abstract | Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging‐related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated.
Alterations in histone modifications play a key role in the loss of partial brain function due to aging. Decreased synaptic and mitochondrial function is a distinctive feature of aging, and these functionally related genes are often accompanied by a decrease in transcriptional activation modification and an increase in inhibitory histone modification during aging, which ultimately leads to a decrease in protein expression. Increased stress and immune responses are often observed during aging, resulting in increased protein expression due to opposite histone modifications in the genes associated with them. This review examines the changes in histone modifications, including methylation and acetylation, that take place as the brain ages and emphasizes the alterations in gene transcription and protein production that these modifications bring about throughout these functional decreases. |
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| AbstractList | Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging‐related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated. Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging‐related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated. Alterations in histone modifications play a key role in the loss of partial brain function due to aging. Decreased synaptic and mitochondrial function is a distinctive feature of aging, and these functionally related genes are often accompanied by a decrease in transcriptional activation modification and an increase in inhibitory histone modification during aging, which ultimately leads to a decrease in protein expression. Increased stress and immune responses are often observed during aging, resulting in increased protein expression due to opposite histone modifications in the genes associated with them. This review examines the changes in histone modifications, including methylation and acetylation, that take place as the brain ages and emphasizes the alterations in gene transcription and protein production that these modifications bring about throughout these functional decreases. Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging-related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated.Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging-related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated. Abstract Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging‐related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated. Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging‐related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated. Alterations in histone modifications play a key role in the loss of partial brain function due to aging. Decreased synaptic and mitochondrial function is a distinctive feature of aging, and these functionally related genes are often accompanied by a decrease in transcriptional activation modification and an increase in inhibitory histone modification during aging, which ultimately leads to a decrease in protein expression. Increased stress and immune responses are often observed during aging, resulting in increased protein expression due to opposite histone modifications in the genes associated with them. This review examines the changes in histone modifications, including methylation and acetylation, that take place as the brain ages and emphasizes the alterations in gene transcription and protein production that these modifications bring about throughout these functional decreases. |
| Author | Ding, Yanwen Zhang, Yi Liu, Chengxi |
| AuthorAffiliation | 2 Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi Guizhou China 3 School of Anesthesiology Zunyi Medical University Zunyi Guizhou China 1 Department of Anesthesiology The Second Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China |
| AuthorAffiliation_xml | – name: 2 Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi Guizhou China – name: 1 Department of Anesthesiology The Second Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China – name: 3 School of Anesthesiology Zunyi Medical University Zunyi Guizhou China |
| Author_xml | – sequence: 1 givenname: Yanwen orcidid: 0000-0001-8103-2618 surname: Ding fullname: Ding, Yanwen organization: Zunyi Medical University – sequence: 2 givenname: Chengxi surname: Liu fullname: Liu, Chengxi organization: Zunyi Medical University – sequence: 3 givenname: Yi surname: Zhang fullname: Zhang, Yi email: cherishher1998@126.com organization: Zunyi Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37786548$$D View this record in MEDLINE/PubMed |
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| Copyright | 2023 The Authors. published by Affiliated Hospital of Zunyi Medical University and Wiley‐VCH GmbH. 2023 The Authors. Ibrain published by Affiliated Hospital of Zunyi Medical University and Wiley‐VCH GmbH. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | acetylation neurodegeneration aging cognitive dysfunction methylation |
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| SubjectTerms | acetylation Age Aging Brain Brain-derived neurotrophic factor Cognitive ability cognitive dysfunction DNA methylation Enzymes Epigenetics Gene expression Memory methylation neurodegeneration Proteins Review Reviews |
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| Title | Aging‐related histone modification changes in brain function |
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