Systematic review: predicting and optimising response to anti‐TNF therapy in Crohn's disease – algorithm for practical management

Summary Background Nonresponse and loss of response to anti‐TNF therapies in Crohn's disease represent significant clinical problems for which clear management guidelines are lacking. Aim To review the incidence, mechanisms and predictors of primary nonresponse and secondary loss of response to...

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Vydané v:	Alimentary pharmacology & therapeutics Ročník 43; číslo 1; s. 30 - 51
Hlavní autori:	Ding, N. S., Hart, A., De Cruz, P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.01.2016
Predmet:	Algorithms Antibodies, Monoclonal - therapeutic use Crohn Disease - drug therapy Crohn Disease - epidemiology Crohn Disease - physiopathology Disease Management Dose-Response Relationship, Drug Drug Monitoring Humans Incidence Prevalence Severity of Illness Index Treatment Failure Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - therapeutic use
ISSN:	0269-2813, 1365-2036
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