Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment

: The development of an autoantibody to human Factor VIII is rare and presents many problems for diagnosis and treatment. We have seen several cases at our institution recently with widely heterogenous clinical and laboratory presentations. A wide range of treatment modalities were used in these cas...

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Bibliographic Details
Published in:	European journal of haematology Vol. 66; no. 3; pp. 206 - 209
Main Authors:	Hall, Rachel L., Leahy, Michael F.
Format:	Journal Article
Language:	English
Published:	Copenhagen Blackwell Publishing Ltd 01.03.2001 Blackwell
Subjects:	Adult Aged Aged, 80 and over Arthritis, Rheumatoid - complications Autoantibodies - immunology autoantibody Autoimmune Diseases - diagnosis Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmune Diseases - therapy Azathioprine - therapeutic use Biological and medical sciences Breast Neoplasms Cardiovascular Agents - therapeutic use Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Chlorambucil - therapeutic use Cyclophosphamide - therapeutic use Factor VIII Factor VIII - immunology Factor VIII - therapeutic use Female Hematologic and hematopoietic diseases Hematoma - etiology Hemophilia A - diagnosis Hemophilia A - etiology Hemophilia A - immunology Hemophilia A - therapy Humans Immunoglobulin G - immunology Immunosuppressive Agents - therapeutic use Infection - etiology inhibitor Leukemia, Lymphocytic, Chronic, B-Cell - complications Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Male Medical sciences Neoplasms, Multiple Primary Partial Thromboplastin Time Platelet diseases and coagulopathies Prednisolone - therapeutic use Retrospective Studies Autoimmunity Human Acquired Antibody Factor VIII Autoantibody Animal origin Hemopathy Hemophilia A Case study Chemotherapy Treatment Prothrombin Inhibitor Concentrate Diagnosis Immunosuppressive agent Recombinant protein Coagulation factor Coagulopathy
ISSN:	0902-4441, 1600-0609
Online Access:	Get full text
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Summary:	: The development of an autoantibody to human Factor VIII is rare and presents many problems for diagnosis and treatment. We have seen several cases at our institution recently with widely heterogenous clinical and laboratory presentations. A wide range of treatment modalities were used in these cases with no gold standard of treatment or widely accepted guidelines existing. This has prompted us to examine all cases of this condition presenting at Fremantle Hospital over the last decade. We describe four cases which demonstrate the heterogeneity of this condition and its treatment and review the recent literature on the subject.
Bibliography:	ArticleID:EJH383 istex:E0ED105637A64A9BDAE3C363D17A491DB78EA5BC ark:/67375/WNG-QQRW03V3-P ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0902-4441 1600-0609
DOI:	10.1034/j.1600-0609.2001.00383.x