Biochemical transformation of mouse cells by herpes simplex virus type 2: enhancement by means of low-level photodynamic treatment

The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only...

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Bibliographic Details
Published in:Journal of virology Vol. 26; no. 1; p. 200
Main Authors: Verwoerd, D W, Rapp, F
Format: Journal Article
Language:English
Published: United States 01.04.1978
Subjects:
Acridines - pharmacology
Cell Line
Cell Transformation, Viral - drug effects
DNA - biosynthesis
DNA, Viral - biosynthesis
Light
Proflavine - pharmacology
Simplexvirus - drug effects
Simplexvirus - growth & development
Simplexvirus - metabolism
ISSN:0022-538X
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Summary:The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.
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ISSN:0022-538X
DOI:10.1128/jvi.26.1.200-202.1978