Biochemical transformation of mouse cells by herpes simplex virus type 2: enhancement by means of low-level photodynamic treatment

The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only...

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Vydané v:Journal of virology Ročník 26; číslo 1; s. 200
Hlavní autori: Verwoerd, D W, Rapp, F
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.04.1978
Predmet:
Acridines - pharmacology
Cell Line
Cell Transformation, Viral - drug effects
DNA - biosynthesis
DNA, Viral - biosynthesis
Light
Proflavine - pharmacology
Simplexvirus - drug effects
Simplexvirus - growth & development
Simplexvirus - metabolism
ISSN:0022-538X
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Abstract The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.
AbstractList The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.
The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.
Author Verwoerd, D W
Rapp, F
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References 5476916 - J Mol Biol. 1970 Jun 14;50(2):263-77
189063 - J Virol. 1977 Jan;21(1):16-23
4355112 - Virology. 1973 Oct;55(2):339-46
165153 - Int J Cancer. 1975 Feb 15;15(2):190-202
References_xml – reference: 4355112 - Virology. 1973 Oct;55(2):339-46
– reference: 165153 - Int J Cancer. 1975 Feb 15;15(2):190-202
– reference: 189063 - J Virol. 1977 Jan;21(1):16-23
– reference: 5476916 - J Mol Biol. 1970 Jun 14;50(2):263-77
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SubjectTerms Acridines - pharmacology
Cell Line
Cell Transformation, Viral - drug effects
DNA - biosynthesis
DNA, Viral - biosynthesis
Light
Proflavine - pharmacology
Simplexvirus - drug effects
Simplexvirus - growth & development
Simplexvirus - metabolism
Title Biochemical transformation of mouse cells by herpes simplex virus type 2: enhancement by means of low-level photodynamic treatment
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