Liposomes and lipid bilayers in biosensors

Biosensors for the rapid, specific, and sensitive detection of analytes play a vital role in healthcare, drug discovery, food safety, and environmental monitoring. Although a number of sensing concepts and devices have been developed, many longstanding challenges to obtain inexpensive, easy-to-use,...

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Bibliographic Details
Published in:Advances in colloid and interface science Vol. 249; pp. 88 - 99
Main Authors: Mazur, Federico, Bally, Marta, Städler, Brigitte, Chandrawati, Rona
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.11.2017
Subjects:
Antigens - analysis
Array
Biomarker
Biomarkers - analysis
Biosensing Techniques - methods
Biosensor
Drug Discovery - methods
Environmental Monitoring - methods
Food Safety - methods
Humans
Lipid bilayer
Lipid Bilayers - chemistry
Liposome
Liposomes - chemistry
Microarray Analysis - instrumentation
Microarray Analysis - methods
Nanostructures - chemistry
Nanotechnology - methods
Pesticides - analysis
Array
Liposome
Lipid bilayer
Biomarker
Biosensor
ISSN:0001-8686, 1873-3727, 1873-3727
Online Access:Get full text
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Summary:Biosensors for the rapid, specific, and sensitive detection of analytes play a vital role in healthcare, drug discovery, food safety, and environmental monitoring. Although a number of sensing concepts and devices have been developed, many longstanding challenges to obtain inexpensive, easy-to-use, and reliable sensor platforms remain largely unmet. Nanomaterials offer exciting possibilities for enhancing the assay sensitivity and for lowering the detection limits down to single-molecule resolution. In this review, we present an overview of liposomes and lipid bilayers in biosensing applications. Lipid assemblies in the form of spherical liposomes or two-dimensional planar membranes have been widely used in the design of biosensing assays; in particular, we highlight a number of recent promising developments of biosensors based on liposomes in suspension, liposome arrays, and lipid bilayers arrays. Assay sensitivity and specificity are discussed, advantages and drawbacks are reviewed, and possible further developments are outlined. [Display omitted] •Biosensors play a vital role in health, food and environmental monitoring•Lipid assemblies in the form of spherical liposomes or 2D planar membranes are widely used in the design of biosensing assays•Liposomes have a large internal cavity for encapsulation of signal markers and a high surface area for conjugation of recognition elements•Planar lipid bilayers are valuable for probing membrane-related biomolecular interactions•Parallel analysis of analytes (multiplexing) requires the integration of recognition elements in an array
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ISSN:0001-8686
1873-3727
1873-3727
DOI:10.1016/j.cis.2017.05.020