The role of weak interactions in evaluation of inhibitory potential of Indinavir as an HIV protease inhibitor and its comparison with innovative drug candidates

Designing and employing enzyme inhibitors against viral enzymes is one of the innovative and efficient approaches to treating viral diseases. These inhibitors can disrupt the viral replication cycle by deactivating vital enzymes, thereby curbing the spread of viral infections by reducing their popul...

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Vydáno v:	Computers in biology and medicine Ročník 187; s. 109675
Hlavní autoři:	Yoosefian, Mehdi, Sabaghian, Hanieh
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Ltd 01.03.2025 Elsevier Limited
Témata:	Acquired immune deficiency syndrome Acquired immunodeficiency syndrome (AIDS) AIDS Analogs Antiretroviral drugs Atoms & subatomic particles Binding Sites Bioavailability Design Design improvements Drug design Drug development Drugs Energy Enzymes FDA approval Genetic algorithms HIV HIV Protease - chemistry HIV Protease - metabolism HIV protease enzyme HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - pharmacology Human immunodeficiency virus Humans Immune system Indinavir Indinavir - analogs & derivatives Indinavir - chemistry Indinavir - pharmacokinetics Indinavir - pharmacology Internal Medicine Ligands Molecular docking Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Optimization Other Performance evaluation Pharmacokinetics Protease Protease inhibitors Proteinase inhibitors Proteins Quantum physics Simulation Toxicity Viral diseases United States > US Drug design Acquired immunodeficiency syndrome (AIDS) Pharmacokinetics HIV protease enzyme Indinavir
ISSN:	0010-4825, 1879-0534, 1879-0534
On-line přístup:	Získat plný text
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