DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

To our knowledge, 17-allylamino,17-demethoxygeldanamycin (17AAG) is the first inhibitor of heat shock protein 90 (Hsp90) to enter a phase I clinical trial in cancer. Inhibition of Hsp90, a chaperone protein (a protein that helps other proteins avoid misfolding pathways that produce inactive or aggre...

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Bibliographic Details
Published in:	JNCI : Journal of the National Cancer Institute Vol. 91; no. 22; p. 1940
Main Authors:	Kelland, L R, Sharp, S Y, Rogers, P M, Myers, T G, Workman, P
Format:	Journal Article
Language:	English
Published:	United States 17.11.1999
Subjects:	Antibiotics, Antineoplastic - pharmacology Benzoquinones Colonic Neoplasms - drug therapy Colonic Neoplasms - enzymology Dihydrolipoamide Dehydrogenase - metabolism Enzyme Inhibitors - pharmacology Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Lactams, Macrocyclic Lactones - pharmacology Macrolides Ovarian Neoplasms - drug therapy Ovarian Neoplasms - enzymology Quinones - pharmacology Rifabutin - analogs & derivatives Rifabutin - pharmacology Tumor Cells, Cultured
ISSN:	0027-8874
Online Access:	Get more information
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