Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells

Mitofusin 2 (Mfn2), a mitochondrial protein, was shown to have antiproliferative properties when overexpressed. In this article, we show that activation of resting human peripheral blood T cells caused downregulation of Mfn2 levels. This downregulation of Mfn2 was blocked by different inhibitors (mT...

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Veröffentlicht in:	The Journal of immunology (1950) Jg. 195; H. 12; S. 5780 - 5786
Hauptverfasser:	Dasgupta, Asish, Chen, Kuang-Hueih, Munk, Rachel B, Sasaki, Carl Y, Curtis, Jessica, Longo, Dan L, Ghosh, Paritosh
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 15.12.2015
Schlagworte:	Cell Cycle - genetics Cell Line, Tumor Cell Proliferation - genetics Chromones - pharmacology Down-Regulation - drug effects Down-Regulation - genetics GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Indazoles - pharmacology Indoles - pharmacology Leukocytes, Mononuclear - immunology Lymphocyte Activation Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Morpholines - pharmacology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism RNA, Small Interfering - genetics Signal Transduction - genetics Sirolimus - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - physiology TOR Serine-Threonine Kinases - metabolism
ISSN:	1550-6606
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