Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels

Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF is necessary to guide clinical management. We hypothesized that a next-generation sequencing (NGS) panel that identifies RAS/BRAF and other actionable mut...

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Veröffentlicht in:	Journal of clinical oncology Jg. 34; H. 18; S. 2141 - 2147
Hauptverfasser:	Stadler, Zsofia K, Battaglin, Francesca, Middha, Sumit, Hechtman, Jaclyn F, Tran, Christina, Cercek, Andrea, Yaeger, Rona, Segal, Neil H, Varghese, Anna M, Reidy-Lagunes, Diane L, Kemeny, Nancy E, Salo-Mullen, Erin E, Ashraf, Asad, Weiser, Martin R, Garcia-Aguilar, Julio, Robson, Mark E, Offit, Kenneth, Arcila, Maria E, Berger, Michael F, Shia, Jinru, Solit, David B, Saltz, Leonard B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.06.2016
Schlagworte:	Adolescent Adult Aged Brain Neoplasms - diagnosis Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics High-Throughput Nucleotide Sequencing - methods Humans Middle Aged Mutation Neoplastic Syndromes, Hereditary - diagnosis
ISSN:	1527-7755
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