Toll-like receptor 4 (TLR4) signaling in the trigeminal ganglion mediates facial mechanical and thermal hyperalgesia in rats

•TLR4 antagonist improved hyperalgesia induced by LPS or mucosal incision.•It was identified an increase of phosphorylated NFκB in the TG in both pain models.•TLR4-NFκB pathway might be involved in pain development in inflammatory oral conditions. There is increasing evidence that the toll-like rece...

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Bibliographic Details
Published in:	Physiology & behavior Vol. 226; p. 113127
Main Authors:	Araya, Erika Ivanna, Barroso, Amanda Ribeiro, Turnes, Joelle de Melo, Radulski, Débora Rasec, Jaganaught, Jovia-Roy Ashley, Zampronio, Aleksander Roberto, Chichorro, Juliana Geremias
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01.11.2020
Subjects:	antagonists behavior ganglia heat Incision lipopolysaccharides LPS males mucosa NFκB pain Postoperative pain somatosensory disorders Toll-like receptor 4 Incision Postoperative pain NFκB LPS Toll-like receptor 4
ISSN:	0031-9384, 1873-507X, 1873-507X
Online Access:	Get full text
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