Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype

Tumor-associated macrophages (TAM) with an alternatively activated phenotype have been linked to tumor-elicited inflammation, immunosuppression, and resistance to chemotherapies in cancer, thus representing an attractive target for an effective cancer immunotherapy. In this study, we demonstrate tha...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 195; no. 10; p. 5055
Main Authors:	Liu, Min, Luo, Fengling, Ding, Chuanlin, Albeituni, Sabrin, Hu, Xiaoling, Ma, Yunfeng, Cai, Yihua, McNally, Lacey, Sanders, Mary Ann, Jain, Dharamvir, Kloecker, Goetz, Bousamra, 2nd, Michael, Zhang, Huang-ge, Higashi, Richard M, Lane, Andrew N, Fan, Teresa W-M, Yan, Jun
Format:	Journal Article
Language:	English
Published:	United States 15.11.2015
Subjects:	Animals beta-Glucans - chemistry beta-Glucans - pharmacology CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - immunology Cell Line, Tumor Fungal Polysaccharides - chemistry Fungal Polysaccharides - pharmacology Lectins, C-Type - immunology Macrophages - immunology Macrophages - metabolism MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Mice Mice, Knockout Neoplasms, Experimental - drug therapy Neoplasms, Experimental - genetics Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Saccharomyces cerevisiae - chemistry
ISSN:	1550-6606, 1550-6606
Online Access:	Get more information
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