Phage–Antibiotic Therapy as a Promising Strategy to Combat Multidrug-Resistant Infections and to Enhance Antimicrobial Efficiency

Infections caused by multidrug-resistant (MDR) bacteria have highlighted the importance of the development of new antimicrobial agents. While bacteriophages (phages) are widely studied as alternative agents to antibiotics, combined treatments using phages and antibiotics have exhibited Phage–Antibio...

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Veröffentlicht in:Antibiotics (Basel) Jg. 11; H. 5; S. 570
Hauptverfasser: Liu, Chengxi, Hong, Qixuan, Chang, Rachel Yoon Kyung, Kwok, Philip Chi Lip, Chan, Hak-Kim
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 25.04.2022
MDPI
Schlagworte:
Adsorption
antibiotic
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial infections
bacteriophage
Cell division
CRISPR
Drug resistance
E coli
Enzymes
Infections
Laboratories
MDR
Multidrug resistance
PAS
Pathogens
Penicillin
phage
Phages
phage–antibiotic therapy
Review
Staphylococcus infections
antibiotic
phage–antibiotic therapy
MDR
PAS
phage
bacteriophage
ISSN:2079-6382, 2079-6382
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Beschreibung
Zusammenfassung:Infections caused by multidrug-resistant (MDR) bacteria have highlighted the importance of the development of new antimicrobial agents. While bacteriophages (phages) are widely studied as alternative agents to antibiotics, combined treatments using phages and antibiotics have exhibited Phage–Antibiotic Synergy (PAS), in which antibiotics promote phage replication and extraordinary antimicrobial efficacy with reduced development of bacterial resistance. This review paper on the current progress of phage–antibiotic therapy includes aspects of the mechanisms of PAS and the therapeutic performance of PAS in combating multidrug-resistant bacterial infections. The choice of phages and antibiotics, the administration time and sequence, and the concentrations of the two agents impact the bacterial inhibitory effects to different extents.
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These authors contributed equally to this work.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11050570