Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function

Thyroid-stimulating hormone (TSH) controls thyroid growth and hormone secretion through binding to its G protein-coupled receptor (TSHR) and production of cyclic AMP (cAMP). Serum TSH is a sensitive indicator of thyroid function, and overt abnormalities in thyroid function lead to common endocrine d...

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Veröffentlicht in:	American journal of human genetics Jg. 82; H. 6; S. 1270
Hauptverfasser:	Arnaud-Lopez, Lisette, Usala, Gianluca, Ceresini, Graziano, Mitchell, Braxton D, Pilia, Maria Grazia, Piras, Maria Grazia, Sestu, Natascia, Maschio, Andrea, Busonero, Fabio, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Mulas, Antonella, Crisponi, Laura, Tanaka, Toshiko, Bandinelli, Stefania, Guralnik, Jack M, Loi, Angela, Balaci, Lenuta, Sole, Gabriella, Prinzis, Alessia, Mariotti, Stefano, Shuldiner, Alan R, Cao, Antonio, Schlessinger, David, Uda, Manuela, Abecasis, Gonçalo R, Nagaraja, Ramaiah, Sanna, Serena, Naitza, Silvia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.06.2008
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - genetics Adolescent Adult Aged Aged, 80 and over Chromosome Mapping Cyclic AMP - metabolism Feedback Female Genetic Variation Humans Linkage Disequilibrium Male Middle Aged Pituitary Gland - physiology Polymorphism, Single Nucleotide Thyroid Diseases - enzymology Thyroid Diseases - genetics Thyroid Diseases - physiopathology Thyroid Gland - enzymology Thyroid Gland - physiology Thyrotropin - blood Thyroxine - biosynthesis Triiodothyronine - biosynthesis
ISSN:	1537-6605, 1537-6605
Online-Zugang:	Weitere Angaben
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