Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function

Thyroid-stimulating hormone (TSH) controls thyroid growth and hormone secretion through binding to its G protein-coupled receptor (TSHR) and production of cyclic AMP (cAMP). Serum TSH is a sensitive indicator of thyroid function, and overt abnormalities in thyroid function lead to common endocrine d...

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Bibliographic Details
Published in:	American journal of human genetics Vol. 82; no. 6; p. 1270
Main Authors:	Arnaud-Lopez, Lisette, Usala, Gianluca, Ceresini, Graziano, Mitchell, Braxton D, Pilia, Maria Grazia, Piras, Maria Grazia, Sestu, Natascia, Maschio, Andrea, Busonero, Fabio, Albai, Giuseppe, Dei, Mariano, Lai, Sandra, Mulas, Antonella, Crisponi, Laura, Tanaka, Toshiko, Bandinelli, Stefania, Guralnik, Jack M, Loi, Angela, Balaci, Lenuta, Sole, Gabriella, Prinzis, Alessia, Mariotti, Stefano, Shuldiner, Alan R, Cao, Antonio, Schlessinger, David, Uda, Manuela, Abecasis, Gonçalo R, Nagaraja, Ramaiah, Sanna, Serena, Naitza, Silvia
Format:	Journal Article
Language:	English
Published:	United States 01.06.2008
Subjects:	3',5'-Cyclic-AMP Phosphodiesterases - genetics Adolescent Adult Aged Aged, 80 and over Chromosome Mapping Cyclic AMP - metabolism Feedback Female Genetic Variation Humans Linkage Disequilibrium Male Middle Aged Pituitary Gland - physiology Polymorphism, Single Nucleotide Thyroid Diseases - enzymology Thyroid Diseases - genetics Thyroid Diseases - physiopathology Thyroid Gland - enzymology Thyroid Gland - physiology Thyrotropin - blood Thyroxine - biosynthesis Triiodothyronine - biosynthesis
ISSN:	1537-6605, 1537-6605
Online Access:	Get more information
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