Intact glycoconjugates from Taenia crassiceps excreted/secreted products ameliorate chemically induced colitis by modulating inflammation and strengthening adherens junctions

Background Ulcerative colitis (UC) is a chronic inflammatory disease that is increasing in prevalence worldwide. Notably, helminth infections, known for their immunoregulatory properties, are inversely related to inflammatory conditions such as UC. Research has indicated that Taenia crassiceps infec...

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Vydáno v:Inflammopharmacology Ročník 33; číslo 8; s. 4725 - 4747
Hlavní autoři: Ledesma-Soto, Yadira, Chávez-Soto, Ilse, Calderón-Torres, Marissa, Rodríguez-Lozoya, Andrea Monserrat, Olguin, Jonadab E., Hernández-Portilla, Luis B., Flores-Ortíz, César M., Candanedo, Fernando, Rodriguez-Sosa, Miriam, Hernández-Navia, Sonia E., Terrazas, Luis I.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.08.2025
Springer Nature B.V
Témata:
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Colitis - chemically induced
Colitis - drug therapy
Colitis, Ulcerative - drug therapy
Colon
Cytokines - metabolism
Dermatology
Dextran Sulfate
Disease Models, Animal
Female
Gastroenterology
Glycoconjugates - metabolism
Glycoconjugates - pharmacology
Immunology
Inflammation - drug therapy
Inflammation - metabolism
Macrophages - drug effects
Macrophages - metabolism
Mice
Mice, Inbred C57BL
Original
Original Article
Pharmacology/Toxicology
Rheumatology
Taenia - metabolism
Carbohydrates
M2 macrophages
Epithelial barrier
Glycans
Colitis
Helminths
Adherens junction
ISSN:0925-4692, 1568-5608, 1568-5608
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Shrnutí:Background Ulcerative colitis (UC) is a chronic inflammatory disease that is increasing in prevalence worldwide. Notably, helminth infections, known for their immunoregulatory properties, are inversely related to inflammatory conditions such as UC. Research has indicated that Taenia crassiceps infection can improve inflammatory-mediated diseases, including type 1 diabetes, experimental autoimmune encephalomyelitis, and colitis. Subsequent studies revealed that helminth-derived products can replicate the effects of complete infection in the context of inflammatory diseases; however, the mechanisms underlying these effects remain unclear. This study examined the impact of intact glycans from T. crassiceps excreted/secreted products (TcES) on host responses to dextran sodium sulfate (DSS)-induced colitis. Methods UC was induced by administering 4% DSS in the drinking water for 9 days. The mice were treated with intact TcES, glycan-depleted TcES, or protein-depleted TcES 2 days after colitis induction. Symptoms of the disease, along with immunologic and histopathological evaluations, were performed. Results Colitic mice that received intact TcES presented fewer disease symptoms and less histopathological damage. Intact TcES reduced the proinflammatory response while increasing the production of IL-4, IL-22, IL-31, and MCP-1 and promoting M2 macrophage polarization via PD-L2 expression. Furthermore, intact TcES diminished neutrophil infiltration, inhibited NF-κB and p38 phosphorylation in the colon, and suppressed reactive oxygen species and 3-nitrotyrosine levels, thus protecting the colon. These effects were accompanied by increased expression of E-cadherin and β-catenin, indicating improved epithelial barrier integrity. Conversely, mice treated with glycan-depleted or protein-depleted TcES exhibited exacerbated colitis characterized by disruption of colon tissue architecture, extensive inflammation, and epithelial damage, including loss of E-cadherin and β-catenin and a lack of M2 macrophage polarization. Conclusions Glycoconjugates on TcES play a significant role in mediating the immunomodulatory effects that alleviate DSS-induced colitis.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0925-4692
1568-5608
1568-5608
DOI:10.1007/s10787-025-01821-y