Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

Abstract The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of adherence and invasion. Heparin, a wide...

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Vydáno v:	Thrombosis and haemostasis Ročník 120; číslo 12; s. 1700 - 1715
Hlavní autoři:	Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Rüdigerstraße 14, 70469 Stuttgart, Germany Georg Thieme Verlag KG 01.12.2020
Témata:	Animals Anticoagulants - pharmacology Anticoagulants - therapeutic use Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Blood Cells, Inflammation and Infection Chlorocebus aethiops COVID-19 - drug therapy Enoxaparin - pharmacology Enoxaparin - therapeutic use Heparin - pharmacology Heparin - therapeutic use Humans Molecular Dynamics Simulation Nebulizers and Vaporizers Protein Binding Protein Conformation Protein Domains - genetics SARS-CoV-2 - physiology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Structure-Activity Relationship Vero Cells Virus Internalization heparin COVID-19 SARS-CoV-2 RBD surface plasmon resonance molecular modelling coronavirus circular dichroism S1 spike
ISSN:	0340-6245, 2567-689X, 2567-689X
On-line přístup:	Získat plný text
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