Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance

Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Biochimica et biophysica acta. Molecular basis of disease Ročník 1866; číslo 4; s. 165339
Hlavní autoři: Makena, Monish Ram, Ranjan, Alok, Thirumala, Vani, Reddy, Arubala P
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.04.2020
Témata:
Cancer stem cells
Immune-modulation
Pathways affecting stem cells
Radio- and chemoresistance
Immune-modulation
HIF
Tregs
PTEN
EMT
ECM
ALDH
MDSCs
Radio- and chemoresistance
MSCs
CAFs
TAMs
ROS
Pathways affecting stem cells
ABC transporters
TLR7
ATRA
Cancer stem cells
NK
CSCs
DC
CART
ISSN:0925-4439, 1879-260X, 1879-260X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the tumor. CSCs also have been shown to be involved in fundamental processes of cell proliferation and metastatic dissemination. CSCs are generally resistant to chemotherapy and radiotherapy, a subset of remaining CSCs after therapy can survive and promote cancer relapse and resistance to therapies. Understanding the biological characteristics of CSCs, the pathways leading to their sustainability and proliferation, and the CSCs role in drug resistance is crucial for establishing novel tumor diagnostic and therapeutic strategies. In this review, we address the pathways that regulate CSCs, the role of CSCs in the resistance to therapy, and strategies to overcome therapeutic resistance. •Cancer stem cells (CSCs) promote cancer relapse and resistance to therapies.•CSCs cause drug resistance by regulating many cellular functions.•Targeting pathways deregulated in CSCs could be a strategy to treat relapse cancers.•Combination of conventional and novel treatments could overcome CSC resistance.
AbstractList Unlike other normal cells, a subpopulation of cells often termed as "stem cells" are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the tumor. CSCs also have been shown to be involved in fundamental processes of cell proliferation and metastatic dissemination. CSCs are generally resistant to chemotherapy and radiotherapy, a subset of remaining CSCs after therapy can survive and promote cancer relapse and resistance to therapies. Understanding the biological characteristics of CSCs, the pathways leading to their sustainability and proliferation, and the CSCs role in drug resistance is crucial for establishing novel tumor diagnostic and therapeutic strategies. In this review, we address the pathways that regulate CSCs, the role of CSCs in the resistance to therapy, and strategies to overcome therapeutic resistance.
Unlike other normal cells, a subpopulation of cells often termed as "stem cells" are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the tumor. CSCs also have been shown to be involved in fundamental processes of cell proliferation and metastatic dissemination. CSCs are generally resistant to chemotherapy and radiotherapy, a subset of remaining CSCs after therapy can survive and promote cancer relapse and resistance to therapies. Understanding the biological characteristics of CSCs, the pathways leading to their sustainability and proliferation, and the CSCs role in drug resistance is crucial for establishing novel tumor diagnostic and therapeutic strategies. In this review, we address the pathways that regulate CSCs, the role of CSCs in the resistance to therapy, and strategies to overcome therapeutic resistance.Unlike other normal cells, a subpopulation of cells often termed as "stem cells" are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the tumor. CSCs also have been shown to be involved in fundamental processes of cell proliferation and metastatic dissemination. CSCs are generally resistant to chemotherapy and radiotherapy, a subset of remaining CSCs after therapy can survive and promote cancer relapse and resistance to therapies. Understanding the biological characteristics of CSCs, the pathways leading to their sustainability and proliferation, and the CSCs role in drug resistance is crucial for establishing novel tumor diagnostic and therapeutic strategies. In this review, we address the pathways that regulate CSCs, the role of CSCs in the resistance to therapy, and strategies to overcome therapeutic resistance.
Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal cells within a tumor that can both self-renew by dividing and giving rise to many cell types that constitute the tumor. CSCs also have been shown to be involved in fundamental processes of cell proliferation and metastatic dissemination. CSCs are generally resistant to chemotherapy and radiotherapy, a subset of remaining CSCs after therapy can survive and promote cancer relapse and resistance to therapies. Understanding the biological characteristics of CSCs, the pathways leading to their sustainability and proliferation, and the CSCs role in drug resistance is crucial for establishing novel tumor diagnostic and therapeutic strategies. In this review, we address the pathways that regulate CSCs, the role of CSCs in the resistance to therapy, and strategies to overcome therapeutic resistance. •Cancer stem cells (CSCs) promote cancer relapse and resistance to therapies.•CSCs cause drug resistance by regulating many cellular functions.•Targeting pathways deregulated in CSCs could be a strategy to treat relapse cancers.•Combination of conventional and novel treatments could overcome CSC resistance.
ArticleNumber 165339
Author Ranjan, Alok
Makena, Monish Ram
Thirumala, Vani
Reddy, Arubala P
Author_xml – sequence: 1
  givenname: Monish Ram
  surname: Makena
  fullname: Makena, Monish Ram
  email: mmakena1@jhmi.edu
  organization: Department of Physiology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America
– sequence: 2
  givenname: Alok
  surname: Ranjan
  fullname: Ranjan, Alok
  organization: Surgical Oncology Program, National Cancer Institute, Bethesda, MD, United States of America
– sequence: 3
  givenname: Vani
  surname: Thirumala
  fullname: Thirumala, Vani
  organization: Department of Neuroscience, University of Texas at Austin, Austin, TX, United States of America
– sequence: 4
  givenname: Arubala P
  surname: Reddy
  fullname: Reddy, Arubala P
  organization: Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX, United States of America
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30481586$$D View this record in MEDLINE/PubMed
BookMark eNqFkE1r3DAQQEVJ6G62-Qel-JiLHY2sleUcCmFpPiAQCAnNTcjSuNWytraSNpB_X5ndltJDMpe5vDcw74QcjX5EQj4DrYCCOF9XXaetixWjICuAisLyA5mDbNqSCfp8ROa0ZcuS87qdkZMY1zSPaOhHMqspl7CUYk6-r_RoMBQx4VAY3GziRfHgtS2SL9JPDHqLu-RMETC6mCa20KPNeNAJfziME-hfMBg_4D_UJ3Lc603E08NekKerb4-rm_Lu_vp2dXlXGs5kKo2WnRRoOTOmAbkEZiUXvaVSIrCOcsu7ntKeMdoDaGgYmpayupWIXFhRL8jZ_u42-F87jEkNLk5_6BH9LioGtRSc8abN6JcDuusGtGob3KDDq_oTIwN8D5jgYwzY_0WAqqm5Wqt9czU1VwAqN8_axX-acUkn58ccyW3ek7_uZcyRXhwGFY3DHNC6gCYp693bB34DaG6fDg
CitedBy_id crossref_primary_10_1007_s12032_021_01524_8
crossref_primary_10_1016_j_jsbmb_2025_106825
crossref_primary_10_1016_j_tranon_2024_102145
crossref_primary_10_1038_s41368_021_00131_7
crossref_primary_10_1136_jitc_2021_003832
crossref_primary_10_3390_cells12162083
crossref_primary_10_1007_s11033_020_05280_2
crossref_primary_10_3390_ijms23073914
crossref_primary_10_3390_cancers13030554
crossref_primary_10_3390_cancers16081463
crossref_primary_10_1002_mame_202400360
crossref_primary_10_1080_20415990_2024_2433938
crossref_primary_10_3390_ncrna11040056
crossref_primary_10_1007_s11033_023_08568_1
crossref_primary_10_1016_j_intimp_2021_107532
crossref_primary_10_3390_ijms24021524
crossref_primary_10_2174_0118715206336851241204111721
crossref_primary_10_3390_biom14121651
crossref_primary_10_1007_s43440_020_00138_7
crossref_primary_10_3390_metabo11010027
crossref_primary_10_1038_s41598_023_32442_6
crossref_primary_10_1016_j_ceca_2019_102109
crossref_primary_10_1158_1541_7786_MCR_24_0652
crossref_primary_10_3390_medsci13020047
crossref_primary_10_4252_wjsc_v13_i8_1112
crossref_primary_10_1016_j_bcp_2024_116252
crossref_primary_10_3390_cells9030644
crossref_primary_10_3390_ijms22136923
crossref_primary_10_3390_cancers16020264
crossref_primary_10_1016_j_ctrv_2025_102939
crossref_primary_10_3390_scipharm92030050
crossref_primary_10_1038_s41392_023_01341_7
crossref_primary_10_1002_smll_202104622
crossref_primary_10_1016_j_scr_2022_102701
crossref_primary_10_1016_j_tips_2023_11_006
crossref_primary_10_1186_s12957_023_03247_8
crossref_primary_10_1186_s13287_022_02856_6
crossref_primary_10_3389_fonc_2019_00626
crossref_primary_10_1016_j_pharmthera_2021_107876
crossref_primary_10_1007_s11684_024_1107_1
crossref_primary_10_1016_j_ijpharm_2025_125381
crossref_primary_10_3389_fcell_2020_585987
crossref_primary_10_3892_ijmm_2023_5272
crossref_primary_10_1038_s41420_023_01339_8
crossref_primary_10_1080_07388551_2024_2435965
crossref_primary_10_1136_jitc_2021_002841
crossref_primary_10_1007_s00432_023_05045_x
crossref_primary_10_1016_j_bcp_2018_11_004
crossref_primary_10_22159_ajpcr_2025v18i4_54115
crossref_primary_10_3389_fonc_2019_00135
crossref_primary_10_1017_erm_2024_23
crossref_primary_10_3390_pathogens12030468
crossref_primary_10_3389_fcell_2025_1619597
crossref_primary_10_3390_ph14070676
crossref_primary_10_1371_journal_pone_0301413
crossref_primary_10_3390_cells13010073
crossref_primary_10_1007_s10238_024_01469_y
crossref_primary_10_3390_biom12050668
crossref_primary_10_3390_cancers13236124
crossref_primary_10_1039_D2FO02932D
crossref_primary_10_2147_IJN_S506456
crossref_primary_10_1016_j_phrs_2021_105759
crossref_primary_10_1080_13543784_2021_1955102
crossref_primary_10_3390_ijms26157452
crossref_primary_10_3390_pharmaceutics15122763
crossref_primary_10_1016_j_drudis_2021_01_015
crossref_primary_10_3389_fcell_2019_00221
crossref_primary_10_1038_s41419_025_07811_w
crossref_primary_10_1002_cam4_3819
crossref_primary_10_1002_cnr2_1809
crossref_primary_10_1097_CAD_0000000000001008
Cites_doi 10.1038/nature07733
10.1101/gad.261982.115
10.1038/nm.2304
10.1158/0008-5472.CAN-14-2800
10.1016/j.ccr.2010.03.011
10.1038/nature05372
10.1158/0008-5472.CAN-15-2249
10.18632/oncotarget.8379
10.1097/CJI.0000000000000242
10.1016/j.addr.2016.02.002
10.1371/journal.pone.0010974
10.1038/nature05236
10.1186/1478-811X-8-6
10.1158/0008-5472.CAN-13-2169
10.1371/journal.pone.0024099
10.1016/j.cub.2006.11.033
10.1016/j.cca.2018.04.033
10.1038/s41568-018-0005-8
10.1038/nature13038
10.1073/pnas.1421365112
10.1186/s12935-017-0448-0
10.1158/1078-0432.CCR-15-2665
10.1111/cas.12691
10.1016/j.molcel.2012.06.014
10.1158/1535-7163.MCT-16-0749
10.1371/journal.pone.0091983
10.1158/0008-5472.CAN-10-3418
10.1016/j.cell.2011.02.013
10.1016/j.celrep.2017.11.025
10.1158/1078-0432.CCR-13-0877
10.1002/ijc.30834
10.1182/blood-2013-05-505735
10.2147/OTT.S109606
10.1182/blood.V99.2.507
10.1158/0008-5472.CAN-14-2111
10.1016/j.immuni.2013.08.025
10.4161/cc.21021
10.18632/oncotarget.1924
10.1097/MD.0000000000004765
10.1016/j.stem.2009.01.007
10.1073/pnas.0530291100
10.17352/2455-8591.000010
10.1038/nrc3184
10.1002/cam4.962
10.1158/0008-5472.CAN-08-1079
10.1146/annurev-pathol-012615-044438
10.1073/pnas.1106645108
10.1080/14712598.2017.1271874
10.1093/carcin/bgw115
10.1038/sj.leu.2404198
10.1016/j.bbrc.2017.11.117
10.1089/scd.2011.0477
10.1111/j.1365-2141.2012.09123.x
10.1158/0008-5472.CAN-10-0732
10.1038/cdd.2008.20
10.1038/nrclinonc.2015.152
10.1093/jnci/djm135
10.3390/cancers6010376
10.1172/JCI66024
10.1038/srep12465
10.1158/0008-5472.CAN-12-4136
10.4103/ctm.ctm_69_16
10.1038/s41467-018-04313-6
10.4252/wjsc.v7.i9.1185
10.1158/0008-5472.CAN-12-2731
10.1155/2015/635745
10.1158/1535-7163.MCT-13-0963
10.3390/cancers8010008
10.1007/s10585-015-9755-9
10.5483/BMBRep.2017.50.6.039
10.1002/stem.1031
10.1016/j.pharmthera.2018.02.001
10.1038/ncomms10068
10.1002/ijc.30234
10.1002/ijc.31219
10.1016/j.pharmthera.2016.02.008
10.1016/j.biotechadv.2013.06.004
10.1002/stem.2473
10.1016/j.ejcsup.2014.03.002
10.1038/nm.4409
10.3390/ijms19071939
10.2174/156720512799361600
10.1093/neuonc/nov157
10.3892/ol.2016.4329
10.1002/stem.1058
10.4103/2278-330X.130445
10.3892/or.2016.5039
10.1371/journal.pone.0003769
10.1038/onc.2016.304
10.1073/pnas.1713728114
10.7150/jca.19732
10.1158/1055-9965.EPI-11-0650
10.1038/s41467-018-05220-6
10.1172/JCI44745
10.3390/ijms18122574
10.1038/nature06835
10.1038/sigtrans.2017.23
10.1073/pnas.0703478104
10.1158/1078-0432.CCR-10-1499
10.1016/j.molcel.2017.04.006
10.1182/blood-2008-08-077941
10.1038/onc.2016.337
10.1073/pnas.0611682104
10.1038/nchem.2778
10.1038/nrm3598
10.1038/nature07737
10.1038/cddis.2017.319
10.1016/j.ccell.2015.12.011
10.1016/j.cell.2014.07.013
10.1177/1947601910379132
10.1038/nrd4253
10.1016/j.trecan.2017.08.007
10.1038/ncb2048
10.1038/srep13744
10.3892/ol.2015.3361
10.1016/j.stem.2015.02.015
10.4161/onci.27231
10.1002/ijc.29921
10.1111/resp.12094
10.3390/cancers7030851
10.7150/ijbs.10248
10.3390/ijms18112362
10.1002/cncr.29244
10.15252/embr.201540678
10.1182/blood-2008-10-186668
10.1016/bs.pmbts.2017.11.007
10.1158/0008-5472.CAN-16-1022
10.3389/fonc.2014.00064
10.1186/s40880-017-0206-7
10.1158/0008-5472.CAN-16-3452
10.1182/blood-2013-02-485607
10.1038/cr.2012.13
10.1016/j.molonc.2013.10.007
10.1038/nature03128
10.1517/14728220903005616
10.3109/03008207.2015.1066780
ContentType Journal Article
Copyright 2018 Elsevier B.V.
Copyright © 2018 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2018 Elsevier B.V.
– notice: Copyright © 2018 Elsevier B.V. All rights reserved.
DBID AAYXX
CITATION
NPM
7X8
DOI 10.1016/j.bbadis.2018.11.015
DatabaseName CrossRef
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Biology
EISSN 1879-260X
ExternalDocumentID 30481586
10_1016_j_bbadis_2018_11_015
S0925443918304769
Genre Journal Article
Review
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1RT
1~.
1~5
23N
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
8P~
9JM
AACTN
AAEDT
AAEDW
AAFTH
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAXUO
ABBQC
ABGSF
ABLVK
ABMAC
ABMZM
ABUDA
ABVKL
ABYKQ
ACDAQ
ACIUM
ACRLP
ADBBV
ADEZE
ADUVX
AEBSH
AEHWI
AEKER
AEXQZ
AFKWA
AFTJW
AFXIZ
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJOXV
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
AXJTR
BKOJK
BLXMC
BNPGV
CS3
DOVZS
EBS
EFJIC
EFLBG
EO8
EO9
EP2
EP3
FDB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
IXB
J1W
KOM
LCYCR
LX3
M41
MO0
N9A
O-L
O9-
OAUVE
OK1
OZT
P-8
P-9
PC.
Q38
ROL
RPZ
SDF
SDG
SDP
SES
SPCBC
SSH
SSU
SSZ
T5K
~G-
3O-
9DU
AAQXK
AATTM
AAXKI
AAYWO
AAYXX
ABEFU
ABFNM
ABWVN
ABXDB
ACIEU
ACLOT
ACRPL
ADMUD
ADNMO
ADVLN
AEIPS
AFJKZ
AGHFR
AGQPQ
AIIUN
ANKPU
APXCP
ASPBG
AVWKF
AZFZN
CITATION
EFKBS
EJD
FEDTE
FGOYB
G-2
HLW
HVGLF
HZ~
IHE
R2-
SBG
SEW
UQL
WUQ
XPP
~HD
NPM
7X8
ID FETCH-LOGICAL-c428t-ca8b86ed42cc718512d846fd088e12b04d4bf00f220f11a172ec902398ee46d63
ISICitedReferencesCount 106
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000515209600007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0925-4439
1879-260X
IngestDate Sat Sep 27 20:30:39 EDT 2025
Thu Apr 03 07:06:33 EDT 2025
Tue Nov 18 22:12:03 EST 2025
Sat Nov 29 07:12:25 EST 2025
Fri Feb 23 02:49:22 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Immune-modulation
HIF
Tregs
PTEN
EMT
ECM
ALDH
MDSCs
Radio- and chemoresistance
MSCs
CAFs
TAMs
ROS
Pathways affecting stem cells
ABC transporters
TLR7
ATRA
Cancer stem cells
NK
CSCs
DC
CART
Language English
License Copyright © 2018 Elsevier B.V. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c428t-ca8b86ed42cc718512d846fd088e12b04d4bf00f220f11a172ec902398ee46d63
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
PMID 30481586
PQID 2138642479
PQPubID 23479
ParticipantIDs proquest_miscellaneous_2138642479
pubmed_primary_30481586
crossref_primary_10_1016_j_bbadis_2018_11_015
crossref_citationtrail_10_1016_j_bbadis_2018_11_015
elsevier_sciencedirect_doi_10_1016_j_bbadis_2018_11_015
PublicationCentury 2000
PublicationDate 2020-04-01
2020-04-00
2020-Apr-01
20200401
PublicationDateYYYYMMDD 2020-04-01
PublicationDate_xml – month: 04
  year: 2020
  text: 2020-04-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Biochimica et biophysica acta. Molecular basis of disease
PublicationTitleAlternate Biochim Biophys Acta Mol Basis Dis
PublicationYear 2020
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Cai, Cao, Luo, Hu, Ling (bb0345) 2018; 483
Li, Chen, Zhu, Zhang, Jiang, Sun (bb0125) 2018; 495
Zhan, Rindtorff, Boutros (bb0195) 2017; 36
Mitchem, Brennan, Knolhoff, Belt, Zhu, Sanford, Belaygorod, Carpenter, Collins, Piwnica-Worms (bb0685) 2013; 73
Hu, Yan, Mu, Huang, Li, Tao, Wu, Qin (bb0480) 2015; 10
Hsu, Xia, Hsu, Chan, Yu, Cha, Chen, Liao, Kuo, Khoo (bb0720) 2018; 9
Dick (bb0375) 2008; 112
Siegel, Miller, Jemal (bb0010) 2017; 67
Cui, Kryczek, Zhao, Zhao, Kuick, Roh, Vatan, Szeliga, Mao, Thomas (bb0690) 2013; 39
Botelho, Alves (bb0555) 2016; 2
Xu, Tang, Xie, Du, Huang, Yu, Cheng (bb0410) 2015; 11
Lee, Das, Lin, Grimes, Zhang, Lavezzi, Huang, Cole, Yau, Li (bb0700) 2012; 158
Gong, Wei, Zhang, Yao, Yuan, Zhou, Lang, Heimberger, Rao, Huang (bb0335) 2015; 75
Liu, Sakamaki, Casimiro, Willmarth, Quong, Ju, Ojeifo, Jiao, Yeow, Katiyar, Shirley, Joyce, Lisanti, Albanese, Pestell (bb0315) 2010; 70
Ramos, Hoffmann, Gerson, Liu (bb0755) 2017; 3
Vermeulen, De Sousa, van der Heijden, Cameron, de Jong, Borovski, Tuynman, Todaro, Merz, Rodermond, Sprick, Kemper, Richel, Stassi, Medema (bb0200) 2010; 12
Tredan, Galmarini, Patel, Tannock (bb0050) 2007; 99
Bao, Ahmad, Azmi, Ali, Sarkar (bb0055) 2013
Hiraga, Ito, Nakamura (bb0170) 2016; 138
Jinushi, Chiba, Yoshiyama, Masutomi, Kinoshita, Dosaka-Akita, Yagita, Takaoka, Tahara (bb0680) 2011; 108
Irvin, Jouanneau, Duvall, Zhang, Zhai, Sarayba, Seksenyan, Panwar, Black, Wheeler (bb0365) 2010; 5
Hanahan, Weinberg (bb0530) 2011; 144
Neradil, Veselska (bb0175) 2015; 106
Gallipoli, Pellicano, Morrison, Laidlaw, Allan, Bhatia, Copland, Jorgensen, Holyoake (bb0310) 2013; 122
Zhang, Strauss, Chu, Li, Ho, Shiang, Snyder, Huettner, Shultz, Holyoake (bb0585) 2010; 17
Matsui (bb0180) 2016; 95
Zhao, Chen, Jamieson, Fereshteh, Abrahamsson, Blum, Kwon, Kim, Chute, Rizzieri, Munchhof, VanArsdale, Beachy, Reya (bb0270) 2009; 458
Tang (bb0350) 2012; 22
Shi, Zhang, Li, Mo, Zhao, Zhu, Hu, Gao, Tan (bb0725) 2018; 142
Nishino, Ozaki, Hegab, Hamamoto, Kagawa, Arai, Yasuda, Naoki, Soejima, Saya (bb0735) 2017; 8
Pathania, Ramachandran, Mariappan, Thakur, Shi, Choi, Manicassamy, Kolhe, Prasad, Sharma, Lokeshwar, Ganapathy, Thangaraju (bb0625) 2016; 76
Diehn, Cho, Lobo, Kalisky, Dorie, Kulp, Qian, Lam, Ailles, Wong (bb0470) 2009; 458
Dalerba, Dylla, Park, Liu, Wang, Cho, Hoey, Gurney, Huang, Simeone, Shelton, Parmiani, Castelli, Clarke (bb0095) 2007; 104
Jia, Li, Andrew, Allan, Li, Lee, Ji, Yao, Gadde, Figeys (bb0505) 2017; 8
Zhao (bb0060) 2016; 160
Guzman, Yang, Sharma, Balys, Corbett, Jordan, Becker, Steidl, Abdel-Wahab, Levine, Marcucci, Roboz, Hassane (bb0610) 2014; 13
Ferrandina, Petrillo, Bonanno, Scambia (bb0145) 2009; 13
Agrawal (bb0015) 2014; 3
Nalls, Tang, Rodova, Srivastava, Shankar (bb0615) 2011; 6
Salvador, Wicinski, Cabaud, Toiron, Finetti, Josselin, Lelièvre, Kraus-Berthier, Depil, Bertucci, Collette, Birnbaum, Charafe-Jauffret, Ginestier (bb0620) 2013; 19
Aceto, Bardia, Miyamoto, Donaldson, Wittner, Spencer, Yu, Pely, Engstrom, Zhu, Brannigan, Kapur, Stott, Shioda, Ramaswamy, Ting, Lin, Toner, Haber, Maheswaran (bb0370) 2014; 158
Witt, Lee, Lee, Azzam, Wang, Caslini, Petrocca, Grosso, Jones, Cohick (bb0595) 2017; 36
Plaks, Kong, Werb (bb0475) 2015; 16
Begicevic, Falasca (bb0115) 2017; 18
Mai, Hamaï, Hienzsch, Cañeque, Müller, Wicinski, Cabaud, Leroy, David, Acevedo (bb0655) 2017; 9
Sultan, Coyle, Vidovic, Thomas, Gujar, Marcato (bb0670) 2016; 38
Cook, Li, Ho, Lin, Li, Stein, Forman, Perrotti, Jove, Bhatia (bb0340) 2014; 123
Clevers (bb0080) 2011; 17
Almozyan, Colak, Mansour, Alaiya, Al-Harazi, Qattan, Al-Mohanna, Al-Alwan, Ghebeh (bb0300) 2017; 141
Cazet, Hui, Elsworth, Wu, Roden, Chan, Skhinas, Collot, Yang, Harvey (bb0485) 2018; 9
Yamashita, Wang (bb0575) 2013; 123
Rodriguez-Torres, Allan (bb0120) 2016; 33
Daverey, Drain, Kidambi (bb0495) 2015; 5
Azab, Runnels, Pitsillides, Moreau, Azab, Leleu, Jia, Wright, Ospina, Carlson (bb0510) 2009; 113
Jang, Kim, Cho, Park, Jung, Lee, Hong, Nam (bb0215) 2015; 5
Singh, Hawkins, Clarke, Squire, Bayani, Hide, Henkelman, Cusimano, Dirks (bb0090) 2004; 432
Komiya, Habas (bb0185) 2008; 4
Alamgeer, Peacock, Matsui, Ganju, Watkins (bb0570) 2013; 18
O'Brien, Pollett, Gallinger, Dick (bb0100) 2007; 445
Moore, Houghton, Lyle (bb0535) 2011; 21
Savard, Ivers, Savard, Morin (bb0025) 2015; 121
Kim, Patel, Ruzevick, Jackson, Lim (bb0330) 2014; 6
Wang, Li, Cui, Jiao, Wu, Jing, Nan (bb0130) 2015; 10
Peacock, Wang, Gesell, Corcoran-Schwartz, Jones, Kim, Devereux, Rhodes, Huff, Beachy, Watkins, Matsui (bb0260) 2007; 104
Scharenberg, Harkey, Torok-Storb (bb0425) 2002; 99
Yabroff, Lund, Kepka, Mariotto (bb0040) 2011; 20
Vermeulen, Sprick, Kemper, Stassi, Medema (bb0075) 2008; 15
Li, Bhatia (bb0355) 2011; 17
Albini, Bruno, Gallo, Pajardi, Noonan, Dallaglio (bb0550) 2015; 56
Makena, Koneru, Nguyen, Kang, Reynolds (bb0600) 2017; 16
Hu, Ghisolfi, Keates, Zhang, Xiang, Lee, Li (bb0405) 2012; 11
Cojoc, Mäbert, Muders, Dubrovska (bb0455) 2015
Shlush, Zandi, Mitchell, Chen, Brandwein, Gupta, Kennedy, Schimmer, Schuh, Yee, McLeod, Doedens, Medeiros, Marke, Kim, Lee, McPherson, Hudson, Consortium, Brown, Yousif, Trinh, Stein, Minden, Wang, Dick (bb0385) 2014; 506
Ren, Wang, Ji, Gao (bb0520) 2016; 11
El Hout, Dos Santos, Hamaï, Mehrpour (bb0660) 2018
Qian, Mei, Zhang (bb0045) 2017; 36
Miao, Xu, Xu, Wang, Zhao, Song, Xu (bb0165) 2017; 6
Shien, Toyooka, Yamamoto, Soh, Jida, Thu, Hashida, Maki, Ichihara, Asano, Tsukuda, Takigawa, Kiura, Gazdar, Lam, Miyoshi (bb0390) 2013; 73
Batlle, Clevers (bb0110) 2017; 23
Cochrane, Szczepny, Watkins, Cain (bb0255) 2015; 7
Liu, Li, Wu, Cho (bb0590) 2017; 8
Luna, Grossenbacher, Murphy, Canter (bb0750) 2017; 17
Welte, Adjaye, Lehrach, Regenbrecht (bb0430) 2010; 8
Lin, Hsieh, Chu, Chen (bb0630) 2018; 19
Vitale, Manic, De Maria, Kroemer, Galluzzi (bb0440) 2017; 66
Xia, Wurmbach, Waxman, Jing (bb0645) 2006; 20
Amit, Gil (bb0675) 2013; 2
Lathia, Mack, Mulkearns-Hubert, Valentim, Rich (bb0070) 2015; 29
Regan, Schumacher, Staudte, Steffen, Haybaeck, Keilholz, Schweiger, Golob-Schwarzl, Mumberg, Henderson, Lehrach, Regenbrecht, Schafer, Lange (bb0275) 2017; 21
Saraswathy, Gong (bb0545) 2013; 31
Marotta, Almendro, Marusyk, Shipitsin, Schemme, Walker, Bloushtain-Qimron, Kim, Choudhury, Maruyama, Wu, Gonen, Mulvey, Bessarabova, Huh, Silver, Kim, Park, Lee, Anderson, Richardson, Nikolskaya, Nikolsky, Liu, Root, Hahn, Frank, Polyak (bb0325) 2011; 121
Zhao, Li, Zhang (bb0065) 2017; 3
Vaiopoulos, Kostakis, Koutsilieris, Papavassiliou (bb0580) 2012; 30
Dragu, Necula, Bleotu, Diaconu, Chivu-Economescu (bb0560) 2015; 7
Prieto-Vila, Takahashi, Usuba, Kohama, Ochiya (bb0525) 2017; 18
Bahena-Ocampo, Espinosa, Ceballos-Cancino, Lizarraga, Campos-Arroyo, Schwarz, Maldonado, Melendez-Zajgla, Garcia-Lopez (bb0295) 2016; 17
Korkaya, Kim, Davis, Malik, Henry, Ithimakin, Quraishi, Tawakkol, D'Angelo, Paulson (bb0500) 2012; 47
Kahn (bb0190) 2018; 153
Nguyen, Vanner, Dirks, Eaves (bb0105) 2012; 12
Nassar, Blanpain (bb0380) 2016; 11
Doherty, Smigiel, Junk, Jackson (bb0635) 2016; 8
Fu, Liu, Sun, Huang, Han, Zhang, Xu, Liu (bb0705) 2017; 17
Porta, Paglino, Mosca (bb0280) 2014; 4
Buoncervello, Romagnoli, Buccarelli, Fragale, Toschi, Parlato, Lucchetti, Macchia, Spada, Canini (bb0715) 2016; 7
Singh, Clarke, Terasaki, Bonn, Hawkins, Squire, Dirks (bb0565) 2003; 63
Moitra (bb0420) 2015; 2015
Bao, Wu, McLendon, Hao, Shi, Hjelmeland, Dewhirst, Bigner, Rich (bb0395) 2006; 444
Malanchi, Peinado, Kassen, Hussenet, Metzger, Chambon, Huber, Hohl, Cano, Birchmeier, Huelsken (bb0210) 2008; 452
Zhong, Shen, Zhou, Mao, Lin, Guan, Xu, Zhang, Liu, Sun (bb0235) 2016; 9
Annett, Robson (bb0540) 2018; 187
Foster, Zaidi, Young, Mobley, Kerr (bb0140) 2018; 6
Koh, Bieberich, Dang, Nelson, Yegnasubramanian, De Marzo (bb0160) 2010; 1
Phillips, Lang, Bohlen, Bethke, Puccio, Tichy, Herold-Mende, Hielscher, Lichter, Goidts (bb0245) 2016; 139
Doherty, Cheon, Junk, Vinayak, Varadan, Telli, Ford, Stark, Jackson (bb0710) 2017; 114
Yuan, Eberhart, Kai (bb0445) 2014; 5
Kim, Ryu (bb0135) 2017; 50
Choy, Hagenbeek, Solon, French, Finkle, Shelton, Venook, Brauer, Siebel (bb0230) 2017; 77
Duan, Yuan, Liu, Ren, Li, Zhang, Wu, Xu, Fu, Li, Yang, Zhang, Bai, Yi, Suzuki, Gao, Esteban, Zhang, Izpisua Belmonte, Chen, Wang, Jiang, Qu, Tang, Liu (bb0285) 2015; 6
Barnawi, Al-Khaldi, Majed Sleiman, Sarkar, Al-Dhfyan, Al-Mohanna, Ghebeh, Al-Alwan (bb0240) 2016; 34
Bao, Wu, Li, Sathornsumetee, Wang, McLendon, Hjelmeland, Rich (bb0360) 2008; 68
Clement, Sanchez, de Tribolet, Radovanovic, Ruiz i Altaba (bb0265) 2007; 17
Krause, Dubrovska, Linge, Baumann (bb0465) 2017; 109
Yan, Chen, Shimada, Tang, Li, Gurumurthy, Khoury, Xu, Huang, Qiu (bb0605) 2018
Teng, Hou, Lee, Chu, Yeh, Jin, Tseng, Tsai, Chang, Wu, Sun, Tsai, Jeng, Nephew, Huang, Hsiao, Leu (bb0490) 2011; 71
Bleau, Hambardzumyan, Ozawa, Fomchenko, Huse, Brennan, Holland (bb0435) 2009; 4
Lechman, Gentner, Ng, Schoof, van Galen, Kennedy, Nucera, Ciceri, Kaufmann, Takayama, Dobson, Trotman-Grant, Krivdova, Elzinga, Mitchell, Nilsson, Hermans, Eppert, Marke, Isserlin, Voisin, Bader, Zandstra, Golub, Ebert, Lu, Minden, Wang, Naldini, Dick (bb0290) 2016; 29
Robey, Pluchino, Hall, Fojo, Bates, Gottesman (bb0415) 2018; 18
Zheng, Dang, Zhang, Xu, Ba, Zhang, Cheng, Chang, Wicha, Li (bb0740) 2018; 41
Abel, Kim, Wu, Hynes, Bednar, Proctor, Wang, Dziubinski, Simeone (bb0225) 2014; 9
Briscoe, Therond (bb0250) 2013; 14
Miller, Siegel, Lin, Mariotto, Kramer, Rowland, Stein, Alteri, Jemal (bb0035) 2016; 66
Al-Hajj, Wicha, Benito-Hernandez, Morrison, Clarke (bb0085) 2003; 100
Sato, Zhao, Ilagan (bb0220) 2012; 9
Guo, Feng, Wang, Han (bb0745) 2017
Aleman, Moser, Nuver, Suter, Maraldo, Specht, Vrieling, Darby (bb0020) 2014; 12
Zhang, Huang, Li, Fu, Xiao (bb0205) 2016; 36
Siegel, Miller, Jemal (bb0005) 2018; 68
Wang, Wang, Li, Wu, Lathia, McLendon, Hjelmeland, Rich (bb0150) 2008; 3
Ajani, Wang, Song, Suzuki, Taketa, Sudo, Wadhwa, Hofstetter, Komaki, Maru (bb0460) 2014; 8
Lee, Shin, Longmire, Wang, Kohrt, Chang, Sunwoo (bb0730) 2016; 22
Lagadec, Vlashi, Della Donna, Dekmezian, Pajonk (bb0400) 2012; 30
Silver, Sinyuk, Vogelbaum, Ahluwalia,
Yang (10.1016/j.bbadis.2018.11.015_bb0155) 2017; 77
Korkaya (10.1016/j.bbadis.2018.11.015_bb0500) 2012; 47
O'Brien (10.1016/j.bbadis.2018.11.015_bb0100) 2007; 445
Daverey (10.1016/j.bbadis.2018.11.015_bb0495) 2015; 5
Jia (10.1016/j.bbadis.2018.11.015_bb0505) 2017; 8
Liu (10.1016/j.bbadis.2018.11.015_bb0590) 2017; 8
Jinushi (10.1016/j.bbadis.2018.11.015_bb0680) 2011; 108
Mitchem (10.1016/j.bbadis.2018.11.015_bb0685) 2013; 73
Bleau (10.1016/j.bbadis.2018.11.015_bb0435) 2009; 4
Batlle (10.1016/j.bbadis.2018.11.015_bb0110) 2017; 23
Koh (10.1016/j.bbadis.2018.11.015_bb0160) 2010; 1
Wang (10.1016/j.bbadis.2018.11.015_bb0150) 2008; 3
Xu (10.1016/j.bbadis.2018.11.015_bb0410) 2015; 11
Cui (10.1016/j.bbadis.2018.11.015_bb0690) 2013; 39
Lin (10.1016/j.bbadis.2018.11.015_bb0630) 2018; 19
Vermeulen (10.1016/j.bbadis.2018.11.015_bb0075) 2008; 15
Hanahan (10.1016/j.bbadis.2018.11.015_bb0530) 2011; 144
Liu (10.1016/j.bbadis.2018.11.015_bb0305) 2017; 2
Luna (10.1016/j.bbadis.2018.11.015_bb0750) 2017; 17
Yamashita (10.1016/j.bbadis.2018.11.015_bb0575) 2013; 123
El Hout (10.1016/j.bbadis.2018.11.015_bb0660) 2018
Nishino (10.1016/j.bbadis.2018.11.015_bb0735) 2017; 8
Ren (10.1016/j.bbadis.2018.11.015_bb0520) 2016; 11
Sato (10.1016/j.bbadis.2018.11.015_bb0220) 2012; 9
Yuan (10.1016/j.bbadis.2018.11.015_bb0445) 2014; 5
Matsui (10.1016/j.bbadis.2018.11.015_bb0180) 2016; 95
Hu (10.1016/j.bbadis.2018.11.015_bb0405) 2012; 11
Prieto-Vila (10.1016/j.bbadis.2018.11.015_bb0525) 2017; 18
Ajani (10.1016/j.bbadis.2018.11.015_bb0460) 2014; 8
Cazet (10.1016/j.bbadis.2018.11.015_bb0485) 2018; 9
Neradil (10.1016/j.bbadis.2018.11.015_bb0175) 2015; 106
Malanchi (10.1016/j.bbadis.2018.11.015_bb0210) 2008; 452
Doherty (10.1016/j.bbadis.2018.11.015_bb0635) 2016; 8
Pattabiraman (10.1016/j.bbadis.2018.11.015_bb0650) 2014; 13
Hu (10.1016/j.bbadis.2018.11.015_bb0480) 2015; 10
Cochrane (10.1016/j.bbadis.2018.11.015_bb0255) 2015; 7
Shi (10.1016/j.bbadis.2018.11.015_bb0725) 2018; 142
Lechman (10.1016/j.bbadis.2018.11.015_bb0290) 2016; 29
Ferrandina (10.1016/j.bbadis.2018.11.015_bb0145) 2009; 13
Duan (10.1016/j.bbadis.2018.11.015_bb0285) 2015; 6
Zheng (10.1016/j.bbadis.2018.11.015_bb0740) 2018; 41
Jang (10.1016/j.bbadis.2018.11.015_bb0215) 2015; 5
Vitale (10.1016/j.bbadis.2018.11.015_bb0440) 2017; 66
Witt (10.1016/j.bbadis.2018.11.015_bb0595) 2017; 36
Bao (10.1016/j.bbadis.2018.11.015_bb0395) 2006; 444
Li (10.1016/j.bbadis.2018.11.015_bb0125) 2018; 495
Choy (10.1016/j.bbadis.2018.11.015_bb0230) 2017; 77
Hiraga (10.1016/j.bbadis.2018.11.015_bb0170) 2016; 138
Stone (10.1016/j.bbadis.2018.11.015_bb0030) 2016; 13
Shien (10.1016/j.bbadis.2018.11.015_bb0390) 2013; 73
Barnawi (10.1016/j.bbadis.2018.11.015_bb0240) 2016; 34
Bahena-Ocampo (10.1016/j.bbadis.2018.11.015_bb0295) 2016; 17
Xia (10.1016/j.bbadis.2018.11.015_bb0645) 2006; 20
Buoncervello (10.1016/j.bbadis.2018.11.015_bb0715) 2016; 7
Ramos (10.1016/j.bbadis.2018.11.015_bb0755) 2017; 3
Zhan (10.1016/j.bbadis.2018.11.015_bb0195) 2017; 36
Welte (10.1016/j.bbadis.2018.11.015_bb0430) 2010; 8
Botelho (10.1016/j.bbadis.2018.11.015_bb0555) 2016; 2
Alamgeer (10.1016/j.bbadis.2018.11.015_bb0570) 2013; 18
Lee (10.1016/j.bbadis.2018.11.015_bb0700) 2012; 158
Rodriguez-Torres (10.1016/j.bbadis.2018.11.015_bb0120) 2016; 33
Bao (10.1016/j.bbadis.2018.11.015_bb0055) 2013
Miller (10.1016/j.bbadis.2018.11.015_bb0035) 2016; 66
Lagadec (10.1016/j.bbadis.2018.11.015_bb0400) 2012; 30
Amit (10.1016/j.bbadis.2018.11.015_bb0675) 2013; 2
Chen (10.1016/j.bbadis.2018.11.015_bb0320) 2015; 75
Kim (10.1016/j.bbadis.2018.11.015_bb0330) 2014; 6
Salvador (10.1016/j.bbadis.2018.11.015_bb0620) 2013; 19
Wang (10.1016/j.bbadis.2018.11.015_bb0130) 2015; 10
Regan (10.1016/j.bbadis.2018.11.015_bb0275) 2017; 21
Kim (10.1016/j.bbadis.2018.11.015_bb0135) 2017; 50
Kahn (10.1016/j.bbadis.2018.11.015_bb0190) 2018; 153
Pathania (10.1016/j.bbadis.2018.11.015_bb0625) 2016; 76
Fu (10.1016/j.bbadis.2018.11.015_bb0705) 2017; 17
Hsu (10.1016/j.bbadis.2018.11.015_bb0720) 2018; 9
Komiya (10.1016/j.bbadis.2018.11.015_bb0185) 2008; 4
Sultan (10.1016/j.bbadis.2018.11.015_bb0670) 2016; 38
Singh (10.1016/j.bbadis.2018.11.015_bb0565) 2003; 63
Liu (10.1016/j.bbadis.2018.11.015_bb0315) 2010; 70
Diehn (10.1016/j.bbadis.2018.11.015_bb0470) 2009; 458
Zhang (10.1016/j.bbadis.2018.11.015_bb0585) 2010; 17
Guo (10.1016/j.bbadis.2018.11.015_bb0745) 2017
Dick (10.1016/j.bbadis.2018.11.015_bb0375) 2008; 112
Irvin (10.1016/j.bbadis.2018.11.015_bb0365) 2010; 5
Lathia (10.1016/j.bbadis.2018.11.015_bb0070) 2015; 29
Doherty (10.1016/j.bbadis.2018.11.015_bb0710) 2017; 114
Teng (10.1016/j.bbadis.2018.11.015_bb0490) 2011; 71
Srivastava (10.1016/j.bbadis.2018.11.015_bb0450) 2015; 112
Moore (10.1016/j.bbadis.2018.11.015_bb0535) 2011; 21
Annett (10.1016/j.bbadis.2018.11.015_bb0540) 2018; 187
Robey (10.1016/j.bbadis.2018.11.015_bb0415) 2018; 18
Yabroff (10.1016/j.bbadis.2018.11.015_bb0040) 2011; 20
Dalerba (10.1016/j.bbadis.2018.11.015_bb0095) 2007; 104
Nassar (10.1016/j.bbadis.2018.11.015_bb0380) 2016; 11
Gong (10.1016/j.bbadis.2018.11.015_bb0335) 2015; 75
Bao (10.1016/j.bbadis.2018.11.015_bb0360) 2008; 68
Yan (10.1016/j.bbadis.2018.11.015_bb0605) 2018
Siegel (10.1016/j.bbadis.2018.11.015_bb0005) 2018; 68
Li (10.1016/j.bbadis.2018.11.015_bb0355) 2011; 17
Agrawal (10.1016/j.bbadis.2018.11.015_bb0015) 2014; 3
Yamashina (10.1016/j.bbadis.2018.11.015_bb0515) 2014; 74
Azab (10.1016/j.bbadis.2018.11.015_bb0510) 2009; 113
Savard (10.1016/j.bbadis.2018.11.015_bb0025) 2015; 121
Saraswathy (10.1016/j.bbadis.2018.11.015_bb0545) 2013; 31
Guzman (10.1016/j.bbadis.2018.11.015_bb0610) 2014; 13
Singh (10.1016/j.bbadis.2018.11.015_bb0090) 2004; 432
Miao (10.1016/j.bbadis.2018.11.015_bb0165) 2017; 6
Qian (10.1016/j.bbadis.2018.11.015_bb0045) 2017; 36
Lee (10.1016/j.bbadis.2018.11.015_bb0730) 2016; 22
Al-Hajj (10.1016/j.bbadis.2018.11.015_bb0085) 2003; 100
Makena (10.1016/j.bbadis.2018.11.015_bb0600) 2017; 16
Tang (10.1016/j.bbadis.2018.11.015_bb0350) 2012; 22
Aceto (10.1016/j.bbadis.2018.11.015_bb0370) 2014; 158
Almozyan (10.1016/j.bbadis.2018.11.015_bb0300) 2017; 141
Moitra (10.1016/j.bbadis.2018.11.015_bb0420) 2015; 2015
Zhao (10.1016/j.bbadis.2018.11.015_bb0065) 2017; 3
Albini (10.1016/j.bbadis.2018.11.015_bb0550) 2015; 56
Zhao (10.1016/j.bbadis.2018.11.015_bb0270) 2009; 458
Scharenberg (10.1016/j.bbadis.2018.11.015_bb0425) 2002; 99
Siegel (10.1016/j.bbadis.2018.11.015_bb0010) 2017; 67
Nalls (10.1016/j.bbadis.2018.11.015_bb0615) 2011; 6
Zhao (10.1016/j.bbadis.2018.11.015_bb0060) 2016; 160
Vermeulen (10.1016/j.bbadis.2018.11.015_bb0200) 2010; 12
Silver (10.1016/j.bbadis.2018.11.015_bb0665) 2015; 18
Briscoe (10.1016/j.bbadis.2018.11.015_bb0250) 2013; 14
Ranjan (10.1016/j.bbadis.2018.11.015_bb0695) 2017; 8
Foster (10.1016/j.bbadis.2018.11.015_bb0140) 2018; 6
Shlush (10.1016/j.bbadis.2018.11.015_bb0385) 2014; 506
Aleman (10.1016/j.bbadis.2018.11.015_bb0020) 2014; 12
Tredan (10.1016/j.bbadis.2018.11.015_bb0050) 2007; 99
Abel (10.1016/j.bbadis.2018.11.015_bb0225) 2014; 9
Phillips (10.1016/j.bbadis.2018.11.015_bb0245) 2016; 139
Porta (10.1016/j.bbadis.2018.11.015_bb0280) 2014; 4
Nguyen (10.1016/j.bbadis.2018.11.015_bb0105) 2012; 12
Gallipoli (10.1016/j.bbadis.2018.11.015_bb0310) 2013; 122
Cojoc (10.1016/j.bbadis.2018.11.015_bb0455) 2015
Cai (10.1016/j.bbadis.2018.11.015_bb0345) 2018; 483
Begicevic (10.1016/j.bbadis.2018.11.015_bb0115) 2017; 18
Zhong (10.1016/j.bbadis.2018.11.015_bb0235) 2016; 9
Krause (10.1016/j.bbadis.2018.11.015_bb0465) 2017; 109
Vaiopoulos (10.1016/j.bbadis.2018.11.015_bb0580) 2012; 30
Mai (10.1016/j.bbadis.2018.11.015_bb0655) 2017; 9
Clevers (10.1016/j.bbadis.2018.11.015_bb0080) 2011; 17
Peacock (10.1016/j.bbadis.2018.11.015_bb0260) 2007; 104
Zhang (10.1016/j.bbadis.2018.11.015_bb0205) 2016; 36
Clement (10.1016/j.bbadis.2018.11.015_bb0265) 2007; 17
Dragu (10.1016/j.bbadis.2018.11.015_bb0560) 2015; 7
Marotta (10.1016/j.bbadis.2018.11.015_bb0325) 2011; 121
Cook (10.1016/j.bbadis.2018.11.015_bb0340) 2014; 123
Hu (10.1016/j.bbadis.2018.11.015_bb0640) 2012; 2
Plaks (10.1016/j.bbadis.2018.11.015_bb0475) 2015; 16
References_xml – volume: 68
  start-page: 7
  year: 2018
  end-page: 30
  ident: bb0005
  article-title: Cancer statistics, 2018
  publication-title: CA Cancer J. Clin.
– start-page: 25
  year: 2013
  ident: bb0055
  article-title: Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy
  publication-title: Curr. Protocol Pharmacol.
– volume: 95
  start-page: S8
  year: 2016
  end-page: S19
  ident: bb0180
  article-title: Cancer stem cell signaling pathways
  publication-title: Medicine (Baltimore)
– volume: 17
  start-page: 427
  year: 2010
  end-page: 442
  ident: bb0585
  article-title: Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
  publication-title: Cancer Cell
– volume: 121
  start-page: 1703
  year: 2015
  end-page: 1711
  ident: bb0025
  article-title: Cancer treatments and their side effects are associated with aggravation of insomnia: results of a longitudinal study
  publication-title: Cancer
– volume: 47
  start-page: 570
  year: 2012
  end-page: 584
  ident: bb0500
  article-title: Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
  publication-title: Mol. Cell
– volume: 12
  start-page: 18
  year: 2014
  end-page: 28
  ident: bb0020
  article-title: Cardiovascular disease after cancer therapy
  publication-title: EJC Suppl.
– volume: 4
  start-page: 68
  year: 2008
  end-page: 75
  ident: bb0185
  article-title: Wnt signal transduction pathways
  publication-title: Organ
– volume: 3
  start-page: 112
  year: 2014
  end-page: 115
  ident: bb0015
  article-title: Late effects of cancer treatment in breast cancer survivors
  publication-title: South Asian J. Cancer
– volume: 11
  start-page: 2691
  year: 2012
  end-page: 2698
  ident: bb0405
  article-title: Induction of cancer cell stemness by chemotherapy
  publication-title: Cell Cycle
– volume: 18
  year: 2017
  ident: bb0115
  article-title: ABC transporters in cancer stem cells: beyond chemoresistance
  publication-title: Int. J. Mol. Sci.
– start-page: 1
  year: 2017
  end-page: 11
  ident: bb0745
  article-title: Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment
  publication-title: Protein Cell
– volume: 67
  start-page: 7
  year: 2017
  end-page: 30
  ident: bb0010
  article-title: Cancer statistics, 2017
  publication-title: CA Cancer J. Clin.
– volume: 13
  start-page: 92
  year: 2016
  end-page: 105
  ident: bb0030
  article-title: Cancer-treatment-induced neurotoxicity—focus on newer treatments
  publication-title: Nat. Rev. Clin. Oncol.
– volume: 13
  start-page: 497
  year: 2014
  ident: bb0650
  article-title: Tackling the cancer stem cells—what challenges do they pose?
  publication-title: Nat. Rev. Drug Discov.
– volume: 4
  start-page: 64
  year: 2014
  ident: bb0280
  article-title: Targeting PI3K/Akt/mTOR signaling in cancer
  publication-title: Front. Oncol.
– year: 2018
  ident: bb0660
  article-title: A promising new approach to cancer therapy: targeting iron metabolism in cancer stem cells
  publication-title: Seminars in Cancer Biology
– volume: 6
  year: 2015
  ident: bb0285
  article-title: PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype
  publication-title: Nat. Commun.
– volume: 6
  start-page: 376
  year: 2014
  end-page: 395
  ident: bb0330
  article-title: STAT3 activation in glioblastoma: biochemical and therapeutic implications
  publication-title: Cancers (Basel)
– volume: 8
  start-page: 142
  year: 2014
  end-page: 149
  ident: bb0460
  article-title: ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients
  publication-title: Mol. Oncol.
– volume: 12
  start-page: 468
  year: 2010
  end-page: 476
  ident: bb0200
  article-title: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
  publication-title: Nat. Cell Biol.
– volume: 2
  year: 2017
  ident: bb0305
  article-title: NF-kappaB signaling in inflammation
  publication-title: Signal Transduction Targeted Ther.
– volume: 138
  start-page: 1698
  year: 2016
  end-page: 1708
  ident: bb0170
  article-title: Ep CAM expression in breast cancer cells is associated with enhanced bone metastasis formation
  publication-title: Int. J. Cancer
– volume: 17
  start-page: 313
  year: 2011
  end-page: 319
  ident: bb0080
  article-title: The cancer stem cell: premises, promises and challenges
  publication-title: Nat. Med.
– year: 2018
  ident: bb0605
  article-title: Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia
  publication-title: Leukemia
– volume: 76
  start-page: 3224
  year: 2016
  end-page: 3235
  ident: bb0625
  article-title: Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth
  publication-title: Cancer Res.
– volume: 73
  start-page: 3051
  year: 2013
  end-page: 3061
  ident: bb0390
  article-title: Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells
  publication-title: Cancer Res.
– volume: 6
  year: 2018
  ident: bb0140
  article-title: CD117/c-kit in cancer stem cell-mediated progression and therapeutic resistance
  publication-title: Biomedicine
– volume: 9
  year: 2018
  ident: bb0485
  article-title: Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
  publication-title: Nat. Commun.
– volume: 2
  year: 2013
  ident: bb0675
  article-title: Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase
  publication-title: Oncoimmunology
– volume: 2015
  year: 2015
  ident: bb0420
  article-title: Overcoming multidrug resistance in cancer stem cells
  publication-title: Biomed. Res. Int.
– volume: 29
  start-page: 214
  year: 2016
  end-page: 228
  ident: bb0290
  article-title: miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells
  publication-title: Cancer Cell
– volume: 160
  start-page: 145
  year: 2016
  end-page: 158
  ident: bb0060
  article-title: Cancer stem cells and chemoresistance: the smartest survives the raid
  publication-title: Pharmacol. Ther.
– volume: 142
  start-page: 2106
  year: 2018
  end-page: 2117
  ident: bb0725
  article-title: PD-1 blockade enhances the antitumor efficacy of GM-CSF surface-modified bladder cancer stem cells vaccine
  publication-title: Int. J. Cancer
– volume: 71
  start-page: 4653
  year: 2011
  end-page: 4663
  ident: bb0490
  article-title: Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells
  publication-title: Cancer Res.
– volume: 10
  year: 2015
  ident: bb0480
  article-title: Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer
  publication-title: PLoS One
– volume: 144
  start-page: 646
  year: 2011
  end-page: 674
  ident: bb0530
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
– start-page: 16
  year: 2015
  end-page: 27
  ident: bb0455
  article-title: A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms
  publication-title: Seminars in Cancer Biology
– volume: 36
  start-page: 2252
  year: 2016
  end-page: 2260
  ident: bb0205
  article-title: Identification of CD200+ colorectal cancer stem cells and their gene expression profile
  publication-title: Oncol. Rep.
– volume: 104
  start-page: 4048
  year: 2007
  end-page: 4053
  ident: bb0260
  article-title: Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 23
  start-page: 1124
  year: 2017
  end-page: 1134
  ident: bb0110
  article-title: Cancer stem cells revisited
  publication-title: Nat. Med.
– volume: 38
  start-page: 107
  year: 2016
  end-page: 118
  ident: bb0670
  article-title: Hide-and-seek: the interplay between cancer stem cells and the immune system
  publication-title: Carcinogenesis
– volume: 14
  start-page: 416
  year: 2013
  end-page: 429
  ident: bb0250
  article-title: The mechanisms of Hedgehog signalling and its roles in development and disease
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 123
  start-page: 2826
  year: 2014
  end-page: 2837
  ident: bb0340
  article-title: Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells
  publication-title: Blood
– volume: 4
  start-page: 226
  year: 2009
  end-page: 235
  ident: bb0435
  article-title: PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
  publication-title: Cell Stem Cell
– volume: 13
  start-page: 1979
  year: 2014
  end-page: 1990
  ident: bb0610
  article-title: Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia
  publication-title: Mol. Cancer Ther.
– volume: 36
  start-page: 1461
  year: 2017
  end-page: 1473
  ident: bb0195
  article-title: Wnt signaling in cancer
  publication-title: Oncogene
– volume: 39
  start-page: 611
  year: 2013
  end-page: 621
  ident: bb0690
  article-title: Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
  publication-title: Immunity
– volume: 8
  start-page: 6
  year: 2010
  ident: bb0430
  article-title: Cancer stem cells in solid tumors: elusive or illusive?
  publication-title: Cell Commun. Signal.
– volume: 3
  year: 2008
  ident: bb0150
  article-title: c-Myc is required for maintenance of glioma cancer stem cells
  publication-title: PLoS One
– volume: 445
  start-page: 106
  year: 2007
  end-page: 110
  ident: bb0100
  article-title: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
  publication-title: Nature
– volume: 100
  start-page: 3983
  year: 2003
  end-page: 3988
  ident: bb0085
  article-title: Prospective identification of tumorigenic breast cancer cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 112
  start-page: 4411
  year: 2015
  end-page: 4416
  ident: bb0450
  article-title: Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 9
  start-page: 227
  year: 2012
  end-page: 240
  ident: bb0220
  article-title: An overview of notch signaling in adult tissue renewal and maintenance
  publication-title: Curr. Alzheimer Res.
– volume: 70
  start-page: 10464
  year: 2010
  end-page: 10473
  ident: bb0315
  article-title: The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion
  publication-title: Cancer Res.
– volume: 158
  start-page: 1110
  year: 2014
  end-page: 1122
  ident: bb0370
  article-title: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
  publication-title: Cell
– volume: 452
  start-page: 650
  year: 2008
  end-page: 653
  ident: bb0210
  article-title: Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
  publication-title: Nature
– volume: 22
  start-page: 457
  year: 2012
  end-page: 472
  ident: bb0350
  article-title: Understanding cancer stem cell heterogeneity and plasticity
  publication-title: Cell Res.
– volume: 12
  start-page: 133
  year: 2012
  end-page: 143
  ident: bb0105
  article-title: Cancer stem cells: an evolving concept
  publication-title: Nat. Rev. Cancer
– volume: 9
  start-page: 1908
  year: 2018
  ident: bb0720
  article-title: STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
  publication-title: Nat. Commun.
– volume: 11
  start-page: 284
  year: 2015
  end-page: 294
  ident: bb0410
  article-title: 5-Fluorouracil chemotherapy of gastric cancer generates residual cells with properties of cancer stem cells
  publication-title: Int. J. Biol. Sci.
– volume: 66
  start-page: 306
  year: 2017
  end-page: 319
  ident: bb0440
  article-title: DNA damage in stem cells
  publication-title: Mol. Cell
– volume: 22
  start-page: 3571
  year: 2016
  end-page: 3581
  ident: bb0730
  article-title: CD44+ cells in head and neck squamous cell carcinoma suppress T-cell-mediated immunity by selective constitutive and inducible expression of PD-L1
  publication-title: Clin. Cancer Res.
– volume: 21
  start-page: 1822
  year: 2011
  end-page: 1830
  ident: bb0535
  article-title: Slow-cycling therapy-resistant cancer cells
  publication-title: Stem Cells Dev.
– volume: 15
  start-page: 947
  year: 2008
  end-page: 958
  ident: bb0075
  article-title: Cancer stem cells—old concepts, new insights
  publication-title: Cell Death Differ.
– volume: 123
  start-page: 1911
  year: 2013
  end-page: 1918
  ident: bb0575
  article-title: Cancer stem cells in the development of liver cancer
  publication-title: J. Clin. Invest.
– volume: 50
  start-page: 285
  year: 2017
  end-page: 298
  ident: bb0135
  article-title: Cancer stem cell surface markers on normal stem cells
  publication-title: BMB Rep.
– volume: 432
  start-page: 396
  year: 2004
  end-page: 401
  ident: bb0090
  article-title: Identification of human brain tumour initiating cells
  publication-title: Nature
– volume: 458
  start-page: 780
  year: 2009
  ident: bb0470
  article-title: Association of reactive oxygen species levels and radioresistance in cancer stem cells
  publication-title: Nature
– volume: 18
  start-page: 757
  year: 2013
  end-page: 764
  ident: bb0570
  article-title: Cancer stem cells in lung cancer: evidence and controversies
  publication-title: Respirology
– volume: 483
  start-page: 156
  year: 2018
  end-page: 163
  ident: bb0345
  article-title: Signalling mechanism(s) of epithelial-mesenchymal transition and cancer stem cells in tumour therapeutic resistance
  publication-title: Clin. Chim. Acta
– volume: 77
  start-page: 1439
  year: 2017
  end-page: 1452
  ident: bb0230
  article-title: Constitutive NOTCH3 signaling promotes the growth of basal breast cancers
  publication-title: Cancer Res.
– volume: 30
  start-page: 363
  year: 2012
  end-page: 371
  ident: bb0580
  article-title: Colorectal cancer stem cells
  publication-title: Stem Cells
– volume: 36
  start-page: 1707
  year: 2017
  ident: bb0595
  article-title: Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer
  publication-title: Oncogene
– volume: 77
  start-page: 6641
  year: 2017
  end-page: 6650
  ident: bb0155
  article-title: MYC inhibition depletes cancer stem-like cells in triple-negative breast cancer
  publication-title: Cancer Res.
– volume: 68
  start-page: 6043
  year: 2008
  end-page: 6048
  ident: bb0360
  article-title: Targeting cancer stem cells through L1CAM suppresses glioma growth
  publication-title: Cancer Res.
– volume: 41
  start-page: 361
  year: 2018
  end-page: 368
  ident: bb0740
  article-title: Cancer stem cell vaccination with PD-L1 and CTLA-4 blockades enhances the eradication of melanoma stem cells in a mouse tumor model
  publication-title: J. Immunother.
– volume: 495
  start-page: 1081
  year: 2018
  end-page: 1088
  ident: bb0125
  article-title: High ALDH activity defines ovarian cancer stem-like cells with enhanced invasiveness and EMT progress which are responsible for tumor invasion
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 75
  start-page: 2337
  year: 2015
  end-page: 2348
  ident: bb0335
  article-title: FoxM1 drives a feed-forward STAT3-activation signaling loop that promotes the self-renewal and tumorigenicity of glioblastoma stem-like cells
  publication-title: Cancer Res.
– volume: 1
  start-page: 617
  year: 2010
  end-page: 628
  ident: bb0160
  article-title: MYC and prostate cancer
  publication-title: Genes Cancer
– volume: 153
  start-page: 209
  year: 2018
  end-page: 244
  ident: bb0190
  article-title: Wnt signaling in stem cells and cancer stem cells: a tale of two coactivators
  publication-title: Prog. Mol. Biol. Transl. Sci.
– volume: 9
  start-page: 6865
  year: 2016
  end-page: 6871
  ident: bb0235
  article-title: NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells
  publication-title: OncoTargets Ther.
– volume: 11
  start-page: 47
  year: 2016
  end-page: 76
  ident: bb0380
  article-title: Cancer stem cells: basic concepts and therapeutic implications
  publication-title: Annu. Rev. Pathol.
– volume: 30
  start-page: 833
  year: 2012
  end-page: 844
  ident: bb0400
  article-title: Radiation-induced reprogramming of breast cancer cells
  publication-title: Stem Cells
– volume: 9
  year: 2014
  ident: bb0225
  article-title: The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer
  publication-title: PLoS One
– volume: 17
  start-page: 648
  year: 2016
  end-page: 658
  ident: bb0295
  article-title: miR-10b expression in breast cancer stem cells supports self-renewal through negative PTEN regulation and sustained AKT activation
  publication-title: EMBO Rep.
– volume: 17
  start-page: 313
  year: 2017
  end-page: 324
  ident: bb0750
  article-title: Targeting cancer stem cells with natural killer cell immunotherapy
  publication-title: Expert. Opin. Biol. Ther.
– volume: 3
  start-page: 780
  year: 2017
  end-page: 796
  ident: bb0755
  article-title: New opportunities and challenges to defeat cancer stem cells
  publication-title: Trends Cancer
– volume: 20
  start-page: 1009
  year: 2006
  ident: bb0645
  article-title: Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis
  publication-title: Leukemia
– volume: 21
  start-page: 2813
  year: 2017
  end-page: 2828
  ident: bb0275
  article-title: Non-canonical hedgehog signaling is a positive regulator of the WNT pathway and is required for the survival of colon cancer stem cells
  publication-title: Cell Rep.
– volume: 73
  start-page: 1128
  year: 2013
  end-page: 1141
  ident: bb0685
  article-title: Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
  publication-title: Cancer Res.
– volume: 10
  start-page: 583
  year: 2015
  end-page: 588
  ident: bb0130
  article-title: BMI-1, a promising therapeutic target for human cancer
  publication-title: Oncol. Lett.
– volume: 139
  start-page: 1776
  year: 2016
  end-page: 1787
  ident: bb0245
  article-title: Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism
  publication-title: Int. J. Cancer
– volume: 112
  start-page: 4793
  year: 2008
  end-page: 4807
  ident: bb0375
  article-title: Stem cell concepts renew cancer research
  publication-title: Blood
– volume: 19
  start-page: 6520
  year: 2013
  end-page: 6531
  ident: bb0620
  article-title: The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression
  publication-title: Clin. Cancer Res.
– volume: 3
  start-page: 87
  year: 2017
  end-page: 95
  ident: bb0065
  article-title: Stemness-related markers in cancer
  publication-title: Cancer Transl. Med.
– volume: 29
  start-page: 1203
  year: 2015
  end-page: 1217
  ident: bb0070
  article-title: Cancer stem cells in glioblastoma
  publication-title: Genes Dev.
– volume: 5
  start-page: 2820
  year: 2014
  ident: bb0445
  article-title: RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation
  publication-title: Oncotarget
– volume: 2
  start-page: 340
  year: 2012
  ident: bb0640
  article-title: Targeting cancer stem cells: a new therapy to cure cancer patients
  publication-title: Am. J. Cancer Res.
– volume: 8
  year: 2017
  ident: bb0590
  article-title: Acetylation and deacetylation in cancer stem-like cells
  publication-title: Oncotarget
– volume: 34
  start-page: 2799
  year: 2016
  end-page: 2813
  ident: bb0240
  article-title: Fascin is critical for the maintenance of breast cancer stem cell pool predominantly via the activation of the Notch self-renewal pathway
  publication-title: Stem Cells
– volume: 2
  start-page: 14
  year: 2016
  ident: bb0555
  article-title: Significance of cancer stem cells in anti-cancer therapies
  publication-title: Int. J. Immunother. Cancer Res.
– volume: 141
  start-page: 1402
  year: 2017
  end-page: 1412
  ident: bb0300
  article-title: PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation
  publication-title: Int. J. Cancer
– volume: 114
  start-page: 13792
  year: 2017
  end-page: 13797
  ident: bb0710
  article-title: Interferon-beta represses cancer stem cell properties in triple-negative breast cancer
  publication-title: Proc. Natl. Acad. Sci.
– volume: 20
  start-page: 2006
  year: 2011
  end-page: 2014
  ident: bb0040
  article-title: Economic burden of cancer in the United States: estimates, projections, and future research
  publication-title: Cancer Epidemiol. Biomark. Prev.
– volume: 187
  start-page: 13
  year: 2018
  end-page: 30
  ident: bb0540
  article-title: Targeting cancer stem cells in the clinic: current status and perspectives
  publication-title: Pharmacol Ther.
– volume: 8
  start-page: 8
  year: 2016
  ident: bb0635
  article-title: Cancer stem cell plasticity drives therapeutic resistance
  publication-title: Cancers
– volume: 444
  start-page: 756
  year: 2006
  end-page: 760
  ident: bb0395
  article-title: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
  publication-title: Nature
– volume: 8
  year: 2017
  ident: bb0695
  article-title: Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth
  publication-title: Oncotarget
– volume: 17
  start-page: 165
  year: 2007
  end-page: 172
  ident: bb0265
  article-title: HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
  publication-title: Curr. Biol.
– volume: 113
  start-page: 4341
  year: 2009
  end-page: 4351
  ident: bb0510
  article-title: CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
  publication-title: Blood
– volume: 5
  year: 2010
  ident: bb0365
  article-title: T cells enhance stem-like properties and conditional malignancy in gliomas
  publication-title: PLoS One
– volume: 56
  start-page: 414
  year: 2015
  end-page: 425
  ident: bb0550
  article-title: Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity
  publication-title: Connect. Tissue Res.
– volume: 6
  year: 2011
  ident: bb0615
  article-title: Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
  publication-title: PLoS One
– volume: 63
  start-page: 5821
  year: 2003
  end-page: 5828
  ident: bb0565
  article-title: Identification of a cancer stem cell in human brain tumors
  publication-title: Cancer Res.
– volume: 19
  start-page: 1939
  year: 2018
  ident: bb0630
  article-title: Therapeutic opportunities of targeting histone deacetylase isoforms to eradicate cancer stem cells
  publication-title: Int. J. Mol. Sci.
– volume: 18
  start-page: 153
  year: 2015
  end-page: 159
  ident: bb0665
  article-title: The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities
  publication-title: Neuro-Oncology
– volume: 13
  start-page: 823
  year: 2009
  end-page: 837
  ident: bb0145
  article-title: Targeting CD133 antigen in cancer
  publication-title: Expert Opin. Ther. Targets
– volume: 18
  start-page: 2574
  year: 2017
  ident: bb0525
  article-title: Drug resistance driven by cancer stem cells and their niche
  publication-title: Int. J. Mol. Sci.
– volume: 106
  start-page: 803
  year: 2015
  end-page: 811
  ident: bb0175
  article-title: Nestin as a marker of cancer stem cells
  publication-title: Cancer Sci.
– volume: 122
  start-page: 3335
  year: 2013
  end-page: 3339
  ident: bb0310
  article-title: Autocrine TNF-alpha production supports CML stem and progenitor cell survival and enhances their proliferation
  publication-title: Blood
– volume: 8
  year: 2017
  ident: bb0505
  article-title: An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells
  publication-title: Cell Death Dis.
– volume: 31
  start-page: 1397
  year: 2013
  end-page: 1407
  ident: bb0545
  article-title: Different strategies to overcome multidrug resistance in cancer
  publication-title: Biotechnol. Adv.
– volume: 108
  start-page: 12425
  year: 2011
  end-page: 12430
  ident: bb0680
  article-title: Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
  publication-title: Proc. Natl. Acad. Sci.
– volume: 7
  start-page: 1554
  year: 2015
  end-page: 1585
  ident: bb0255
  article-title: Hedgehog signaling in the maintenance of cancer stem cells
  publication-title: Cancers (Basel)
– volume: 99
  start-page: 507
  year: 2002
  end-page: 512
  ident: bb0425
  article-title: The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
  publication-title: Blood
– volume: 7
  start-page: 1185
  year: 2015
  ident: bb0560
  article-title: Therapies targeting cancer stem cells: current trends and future challenges
  publication-title: World J. Stem Cells
– volume: 6
  start-page: 245
  year: 2017
  end-page: 257
  ident: bb0165
  article-title: DLL4 overexpression increases gastric cancer stem/progenitor cell self-renewal ability and correlates with poor clinical outcome via Notch-1 signaling pathway activation
  publication-title: Cancer Med.
– volume: 16
  start-page: 225
  year: 2015
  end-page: 238
  ident: bb0475
  article-title: The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?
  publication-title: Cell Stem Cell
– volume: 158
  start-page: 79
  year: 2012
  end-page: 90
  ident: bb0700
  article-title: A rare fraction of drug-resistant follicular lymphoma cancer stem cells interacts with follicular dendritic cells to maintain tumourigenic potential
  publication-title: Br. J. Haematol.
– volume: 8
  start-page: 1774
  year: 2017
  ident: bb0735
  article-title: Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma
  publication-title: J. Cancer
– volume: 36
  start-page: 38
  year: 2017
  ident: bb0045
  article-title: Cancer metastasis: issues and challenges
  publication-title: Chin. J. Cancer
– volume: 109
  start-page: 63
  year: 2017
  end-page: 73
  ident: bb0465
  article-title: Cancer stem cells: radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
  publication-title: Adv. Drug Deliv. Rev.
– volume: 104
  start-page: 10158
  year: 2007
  end-page: 10163
  ident: bb0095
  article-title: Phenotypic characterization of human colorectal cancer stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 9
  start-page: 1025
  year: 2017
  ident: bb0655
  article-title: Salinomycin kills cancer stem cells by sequestering iron in lysosomes
  publication-title: Nat. Chem.
– volume: 18
  start-page: 452
  year: 2018
  end-page: 464
  ident: bb0415
  article-title: Revisiting the role of ABC transporters in multidrug-resistant cancer
  publication-title: Nat. Rev. Cancer
– volume: 66
  start-page: 271
  year: 2016
  end-page: 289
  ident: bb0035
  article-title: Cancer treatment and survivorship statistics, 2016
  publication-title: CA Cancer J. Clin.
– volume: 17
  start-page: 4936
  year: 2011
  end-page: 4941
  ident: bb0355
  article-title: Stem cell quiescence
  publication-title: Clin. Cancer Res.
– volume: 74
  start-page: 2698
  year: 2014
  end-page: 2709
  ident: bb0515
  article-title: Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells
  publication-title: Cancer Res.
– volume: 5
  year: 2015
  ident: bb0215
  article-title: Blockade of Wnt/beta-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype
  publication-title: Sci. Rep.
– volume: 99
  start-page: 1441
  year: 2007
  end-page: 1454
  ident: bb0050
  article-title: Drug resistance and the solid tumor microenvironment
  publication-title: J. Natl. Cancer Inst.
– volume: 11
  start-page: 2965
  year: 2016
  end-page: 2970
  ident: bb0520
  article-title: TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-κB-IL6 signaling pathway
  publication-title: Oncol. Lett.
– volume: 458
  start-page: 776
  year: 2009
  end-page: 779
  ident: bb0270
  article-title: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
  publication-title: Nature
– volume: 121
  start-page: 2723
  year: 2011
  end-page: 2735
  ident: bb0325
  article-title: The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(−) stem cell-like breast cancer cells in human tumors
  publication-title: J. Clin. Invest.
– volume: 5
  year: 2015
  ident: bb0495
  article-title: Physical intimacy of breast cancer cells with mesenchymal stem cells elicits trastuzumab resistance through Src activation
  publication-title: Sci. Rep.
– volume: 17
  start-page: 79
  year: 2017
  ident: bb0705
  article-title: Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway
  publication-title: Cancer Cell Int.
– volume: 506
  start-page: 328
  year: 2014
  end-page: 333
  ident: bb0385
  article-title: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
  publication-title: Nature
– volume: 33
  start-page: 97
  year: 2016
  end-page: 113
  ident: bb0120
  article-title: Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors
  publication-title: Clin. Exp. Metastasis
– volume: 16
  start-page: 649
  year: 2017
  end-page: 661
  ident: bb0600
  article-title: Reactive oxygen species-mediated synergism of fenretinide and romidepsin in preclinical models of T-cell lymphoid malignancies
  publication-title: Mol. Cancer Ther.
– volume: 7
  year: 2016
  ident: bb0715
  article-title: IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer
  publication-title: Oncotarget
– volume: 75
  start-page: 1725
  year: 2015
  end-page: 1735
  ident: bb0320
  article-title: IKKbeta enforces a LIN28B/TCF7L2 positive feedback loop that promotes cancer cell stemness and metastasis
  publication-title: Cancer Res.
– volume: 458
  start-page: 780
  year: 2009
  ident: 10.1016/j.bbadis.2018.11.015_bb0470
  article-title: Association of reactive oxygen species levels and radioresistance in cancer stem cells
  publication-title: Nature
  doi: 10.1038/nature07733
– volume: 29
  start-page: 1203
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0070
  article-title: Cancer stem cells in glioblastoma
  publication-title: Genes Dev.
  doi: 10.1101/gad.261982.115
– volume: 17
  start-page: 313
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0080
  article-title: The cancer stem cell: premises, promises and challenges
  publication-title: Nat. Med.
  doi: 10.1038/nm.2304
– volume: 75
  start-page: 2337
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0335
  article-title: FoxM1 drives a feed-forward STAT3-activation signaling loop that promotes the self-renewal and tumorigenicity of glioblastoma stem-like cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-2800
– volume: 17
  start-page: 427
  year: 2010
  ident: 10.1016/j.bbadis.2018.11.015_bb0585
  article-title: Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.03.011
– volume: 445
  start-page: 106
  year: 2007
  ident: 10.1016/j.bbadis.2018.11.015_bb0100
  article-title: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
  publication-title: Nature
  doi: 10.1038/nature05372
– volume: 76
  start-page: 3224
  issue: 11
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0625
  article-title: Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-15-2249
– volume: 7
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0715
  article-title: IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8379
– volume: 41
  start-page: 361
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0740
  article-title: Cancer stem cell vaccination with PD-L1 and CTLA-4 blockades enhances the eradication of melanoma stem cells in a mouse tumor model
  publication-title: J. Immunother.
  doi: 10.1097/CJI.0000000000000242
– volume: 109
  start-page: 63
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0465
  article-title: Cancer stem cells: radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.02.002
– volume: 2
  start-page: 340
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0640
  article-title: Targeting cancer stem cells: a new therapy to cure cancer patients
  publication-title: Am. J. Cancer Res.
– volume: 5
  year: 2010
  ident: 10.1016/j.bbadis.2018.11.015_bb0365
  article-title: T cells enhance stem-like properties and conditional malignancy in gliomas
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0010974
– volume: 444
  start-page: 756
  year: 2006
  ident: 10.1016/j.bbadis.2018.11.015_bb0395
  article-title: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
  publication-title: Nature
  doi: 10.1038/nature05236
– volume: 8
  start-page: 6
  year: 2010
  ident: 10.1016/j.bbadis.2018.11.015_bb0430
  article-title: Cancer stem cells in solid tumors: elusive or illusive?
  publication-title: Cell Commun. Signal.
  doi: 10.1186/1478-811X-8-6
– volume: 74
  start-page: 2698
  issue: 10
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0515
  article-title: Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-2169
– volume: 6
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0615
  article-title: Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0024099
– volume: 17
  start-page: 165
  year: 2007
  ident: 10.1016/j.bbadis.2018.11.015_bb0265
  article-title: HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2006.11.033
– volume: 483
  start-page: 156
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0345
  article-title: Signalling mechanism(s) of epithelial-mesenchymal transition and cancer stem cells in tumour therapeutic resistance
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2018.04.033
– volume: 18
  start-page: 452
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0415
  article-title: Revisiting the role of ABC transporters in multidrug-resistant cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0005-8
– volume: 63
  start-page: 5821
  year: 2003
  ident: 10.1016/j.bbadis.2018.11.015_bb0565
  article-title: Identification of a cancer stem cell in human brain tumors
  publication-title: Cancer Res.
– volume: 506
  start-page: 328
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0385
  article-title: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
  publication-title: Nature
  doi: 10.1038/nature13038
– volume: 112
  start-page: 4411
  issue: 14
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0450
  article-title: Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1421365112
– volume: 17
  start-page: 79
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0705
  article-title: Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway
  publication-title: Cancer Cell Int.
  doi: 10.1186/s12935-017-0448-0
– volume: 22
  start-page: 3571
  issue: 14
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0730
  article-title: CD44+ cells in head and neck squamous cell carcinoma suppress T-cell-mediated immunity by selective constitutive and inducible expression of PD-L1
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-15-2665
– volume: 106
  start-page: 803
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0175
  article-title: Nestin as a marker of cancer stem cells
  publication-title: Cancer Sci.
  doi: 10.1111/cas.12691
– volume: 47
  start-page: 570
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0500
  article-title: Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.06.014
– volume: 16
  start-page: 649
  issue: 4
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0600
  article-title: Reactive oxygen species-mediated synergism of fenretinide and romidepsin in preclinical models of T-cell lymphoid malignancies
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-16-0749
– year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0605
  article-title: Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia
  publication-title: Leukemia
– volume: 9
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0225
  article-title: The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0091983
– volume: 71
  start-page: 4653
  issue: 13
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0490
  article-title: Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-3418
– volume: 144
  start-page: 646
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0530
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 21
  start-page: 2813
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0275
  article-title: Non-canonical hedgehog signaling is a positive regulator of the WNT pathway and is required for the survival of colon cancer stem cells
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.11.025
– volume: 19
  start-page: 6520
  issue: 23
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0620
  article-title: The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-13-0877
– volume: 141
  start-page: 1402
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0300
  article-title: PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.30834
– volume: 123
  start-page: 2826
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0340
  article-title: Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells
  publication-title: Blood
  doi: 10.1182/blood-2013-05-505735
– volume: 9
  start-page: 6865
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0235
  article-title: NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells
  publication-title: OncoTargets Ther.
  doi: 10.2147/OTT.S109606
– volume: 99
  start-page: 507
  year: 2002
  ident: 10.1016/j.bbadis.2018.11.015_bb0425
  article-title: The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
  publication-title: Blood
  doi: 10.1182/blood.V99.2.507
– volume: 75
  start-page: 1725
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0320
  article-title: IKKbeta enforces a LIN28B/TCF7L2 positive feedback loop that promotes cancer cell stemness and metastasis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-2111
– volume: 39
  start-page: 611
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0690
  article-title: Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.025
– volume: 11
  start-page: 2691
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0405
  article-title: Induction of cancer cell stemness by chemotherapy
  publication-title: Cell Cycle
  doi: 10.4161/cc.21021
– start-page: 1
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0745
  article-title: Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment
  publication-title: Protein Cell
– volume: 5
  start-page: 2820
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0445
  article-title: RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.1924
– volume: 95
  start-page: S8
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0180
  article-title: Cancer stem cell signaling pathways
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000004765
– volume: 4
  start-page: 226
  year: 2009
  ident: 10.1016/j.bbadis.2018.11.015_bb0435
  article-title: PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2009.01.007
– volume: 100
  start-page: 3983
  year: 2003
  ident: 10.1016/j.bbadis.2018.11.015_bb0085
  article-title: Prospective identification of tumorigenic breast cancer cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0530291100
– volume: 2
  start-page: 14
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0555
  article-title: Significance of cancer stem cells in anti-cancer therapies
  publication-title: Int. J. Immunother. Cancer Res.
  doi: 10.17352/2455-8591.000010
– volume: 12
  start-page: 133
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0105
  article-title: Cancer stem cells: an evolving concept
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3184
– volume: 6
  start-page: 245
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0165
  article-title: DLL4 overexpression increases gastric cancer stem/progenitor cell self-renewal ability and correlates with poor clinical outcome via Notch-1 signaling pathway activation
  publication-title: Cancer Med.
  doi: 10.1002/cam4.962
– volume: 8
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0695
  article-title: Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth
  publication-title: Oncotarget
– volume: 68
  start-page: 6043
  year: 2008
  ident: 10.1016/j.bbadis.2018.11.015_bb0360
  article-title: Targeting cancer stem cells through L1CAM suppresses glioma growth
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-1079
– volume: 11
  start-page: 47
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0380
  article-title: Cancer stem cells: basic concepts and therapeutic implications
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-012615-044438
– volume: 108
  start-page: 12425
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0680
  article-title: Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.1106645108
– volume: 17
  start-page: 313
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0750
  article-title: Targeting cancer stem cells with natural killer cell immunotherapy
  publication-title: Expert. Opin. Biol. Ther.
  doi: 10.1080/14712598.2017.1271874
– volume: 38
  start-page: 107
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0670
  article-title: Hide-and-seek: the interplay between cancer stem cells and the immune system
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgw115
– volume: 20
  start-page: 1009
  year: 2006
  ident: 10.1016/j.bbadis.2018.11.015_bb0645
  article-title: Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404198
– volume: 495
  start-page: 1081
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0125
  article-title: High ALDH activity defines ovarian cancer stem-like cells with enhanced invasiveness and EMT progress which are responsible for tumor invasion
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2017.11.117
– volume: 66
  start-page: 271
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0035
  article-title: Cancer treatment and survivorship statistics, 2016
  publication-title: CA Cancer J. Clin.
– volume: 21
  start-page: 1822
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0535
  article-title: Slow-cycling therapy-resistant cancer cells
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2011.0477
– volume: 158
  start-page: 79
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0700
  article-title: A rare fraction of drug-resistant follicular lymphoma cancer stem cells interacts with follicular dendritic cells to maintain tumourigenic potential
  publication-title: Br. J. Haematol.
  doi: 10.1111/j.1365-2141.2012.09123.x
– volume: 70
  start-page: 10464
  year: 2010
  ident: 10.1016/j.bbadis.2018.11.015_bb0315
  article-title: The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-0732
– volume: 15
  start-page: 947
  year: 2008
  ident: 10.1016/j.bbadis.2018.11.015_bb0075
  article-title: Cancer stem cells—old concepts, new insights
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2008.20
– volume: 13
  start-page: 92
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0030
  article-title: Cancer-treatment-induced neurotoxicity—focus on newer treatments
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2015.152
– volume: 99
  start-page: 1441
  year: 2007
  ident: 10.1016/j.bbadis.2018.11.015_bb0050
  article-title: Drug resistance and the solid tumor microenvironment
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/djm135
– volume: 6
  start-page: 376
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0330
  article-title: STAT3 activation in glioblastoma: biochemical and therapeutic implications
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers6010376
– volume: 123
  start-page: 1911
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0575
  article-title: Cancer stem cells in the development of liver cancer
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI66024
– volume: 5
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0215
  article-title: Blockade of Wnt/beta-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype
  publication-title: Sci. Rep.
  doi: 10.1038/srep12465
– volume: 73
  start-page: 3051
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0390
  article-title: Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-4136
– volume: 8
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0590
  article-title: Acetylation and deacetylation in cancer stem-like cells
  publication-title: Oncotarget
– volume: 3
  start-page: 87
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0065
  article-title: Stemness-related markers in cancer
  publication-title: Cancer Transl. Med.
  doi: 10.4103/ctm.ctm_69_16
– start-page: 16
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0455
  article-title: A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms
– volume: 9
  start-page: 1908
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0720
  article-title: STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04313-6
– volume: 7
  start-page: 1185
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0560
  article-title: Therapies targeting cancer stem cells: current trends and future challenges
  publication-title: World J. Stem Cells
  doi: 10.4252/wjsc.v7.i9.1185
– volume: 73
  start-page: 1128
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0685
  article-title: Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-2731
– volume: 6
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0140
  article-title: CD117/c-kit in cancer stem cell-mediated progression and therapeutic resistance
  publication-title: Biomedicine
– volume: 2015
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0420
  article-title: Overcoming multidrug resistance in cancer stem cells
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2015/635745
– volume: 13
  start-page: 1979
  issue: 8
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0610
  article-title: Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-13-0963
– volume: 8
  start-page: 8
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0635
  article-title: Cancer stem cell plasticity drives therapeutic resistance
  publication-title: Cancers
  doi: 10.3390/cancers8010008
– volume: 33
  start-page: 97
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0120
  article-title: Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-015-9755-9
– volume: 50
  start-page: 285
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0135
  article-title: Cancer stem cell surface markers on normal stem cells
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2017.50.6.039
– volume: 30
  start-page: 363
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0580
  article-title: Colorectal cancer stem cells
  publication-title: Stem Cells
  doi: 10.1002/stem.1031
– volume: 187
  start-page: 13
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0540
  article-title: Targeting cancer stem cells in the clinic: current status and perspectives
  publication-title: Pharmacol Ther.
  doi: 10.1016/j.pharmthera.2018.02.001
– volume: 6
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0285
  article-title: PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms10068
– volume: 139
  start-page: 1776
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0245
  article-title: Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.30234
– volume: 142
  start-page: 2106
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0725
  article-title: PD-1 blockade enhances the antitumor efficacy of GM-CSF surface-modified bladder cancer stem cells vaccine
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.31219
– volume: 160
  start-page: 145
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0060
  article-title: Cancer stem cells and chemoresistance: the smartest survives the raid
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2016.02.008
– volume: 31
  start-page: 1397
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0545
  article-title: Different strategies to overcome multidrug resistance in cancer
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2013.06.004
– volume: 34
  start-page: 2799
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0240
  article-title: Fascin is critical for the maintenance of breast cancer stem cell pool predominantly via the activation of the Notch self-renewal pathway
  publication-title: Stem Cells
  doi: 10.1002/stem.2473
– volume: 12
  start-page: 18
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0020
  article-title: Cardiovascular disease after cancer therapy
  publication-title: EJC Suppl.
  doi: 10.1016/j.ejcsup.2014.03.002
– volume: 4
  start-page: 68
  year: 2008
  ident: 10.1016/j.bbadis.2018.11.015_bb0185
  article-title: Wnt signal transduction pathways
  publication-title: Organ
– volume: 23
  start-page: 1124
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0110
  article-title: Cancer stem cells revisited
  publication-title: Nat. Med.
  doi: 10.1038/nm.4409
– volume: 19
  start-page: 1939
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0630
  article-title: Therapeutic opportunities of targeting histone deacetylase isoforms to eradicate cancer stem cells
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms19071939
– volume: 9
  start-page: 227
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0220
  article-title: An overview of notch signaling in adult tissue renewal and maintenance
  publication-title: Curr. Alzheimer Res.
  doi: 10.2174/156720512799361600
– volume: 18
  start-page: 153
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0665
  article-title: The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities
  publication-title: Neuro-Oncology
  doi: 10.1093/neuonc/nov157
– volume: 11
  start-page: 2965
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0520
  article-title: TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-κB-IL6 signaling pathway
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2016.4329
– volume: 30
  start-page: 833
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0400
  article-title: Radiation-induced reprogramming of breast cancer cells
  publication-title: Stem Cells
  doi: 10.1002/stem.1058
– volume: 3
  start-page: 112
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0015
  article-title: Late effects of cancer treatment in breast cancer survivors
  publication-title: South Asian J. Cancer
  doi: 10.4103/2278-330X.130445
– volume: 36
  start-page: 2252
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0205
  article-title: Identification of CD200+ colorectal cancer stem cells and their gene expression profile
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2016.5039
– volume: 3
  year: 2008
  ident: 10.1016/j.bbadis.2018.11.015_bb0150
  article-title: c-Myc is required for maintenance of glioma cancer stem cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003769
– volume: 36
  start-page: 1461
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0195
  article-title: Wnt signaling in cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2016.304
– volume: 114
  start-page: 13792
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0710
  article-title: Interferon-beta represses cancer stem cell properties in triple-negative breast cancer
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.1713728114
– volume: 8
  start-page: 1774
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0735
  article-title: Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma
  publication-title: J. Cancer
  doi: 10.7150/jca.19732
– volume: 20
  start-page: 2006
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0040
  article-title: Economic burden of cancer in the United States: estimates, projections, and future research
  publication-title: Cancer Epidemiol. Biomark. Prev.
  doi: 10.1158/1055-9965.EPI-11-0650
– volume: 9
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0485
  article-title: Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05220-6
– volume: 121
  start-page: 2723
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0325
  article-title: The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(−) stem cell-like breast cancer cells in human tumors
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI44745
– volume: 18
  start-page: 2574
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0525
  article-title: Drug resistance driven by cancer stem cells and their niche
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18122574
– volume: 452
  start-page: 650
  year: 2008
  ident: 10.1016/j.bbadis.2018.11.015_bb0210
  article-title: Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
  publication-title: Nature
  doi: 10.1038/nature06835
– volume: 2
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0305
  article-title: NF-kappaB signaling in inflammation
  publication-title: Signal Transduction Targeted Ther.
  doi: 10.1038/sigtrans.2017.23
– volume: 104
  start-page: 10158
  year: 2007
  ident: 10.1016/j.bbadis.2018.11.015_bb0095
  article-title: Phenotypic characterization of human colorectal cancer stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0703478104
– volume: 17
  start-page: 4936
  year: 2011
  ident: 10.1016/j.bbadis.2018.11.015_bb0355
  article-title: Stem cell quiescence
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-10-1499
– volume: 66
  start-page: 306
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0440
  article-title: DNA damage in stem cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.04.006
– volume: 112
  start-page: 4793
  year: 2008
  ident: 10.1016/j.bbadis.2018.11.015_bb0375
  article-title: Stem cell concepts renew cancer research
  publication-title: Blood
  doi: 10.1182/blood-2008-08-077941
– volume: 36
  start-page: 1707
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0595
  article-title: Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2016.337
– volume: 104
  start-page: 4048
  year: 2007
  ident: 10.1016/j.bbadis.2018.11.015_bb0260
  article-title: Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0611682104
– volume: 9
  start-page: 1025
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0655
  article-title: Salinomycin kills cancer stem cells by sequestering iron in lysosomes
  publication-title: Nat. Chem.
  doi: 10.1038/nchem.2778
– start-page: 25
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0055
  article-title: Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy
  publication-title: Curr. Protocol Pharmacol.
– volume: 14
  start-page: 416
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0250
  article-title: The mechanisms of Hedgehog signalling and its roles in development and disease
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3598
– volume: 458
  start-page: 776
  year: 2009
  ident: 10.1016/j.bbadis.2018.11.015_bb0270
  article-title: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
  publication-title: Nature
  doi: 10.1038/nature07737
– volume: 8
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0505
  article-title: An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2017.319
– volume: 29
  start-page: 214
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0290
  article-title: miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.12.011
– volume: 158
  start-page: 1110
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0370
  article-title: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.013
– volume: 1
  start-page: 617
  year: 2010
  ident: 10.1016/j.bbadis.2018.11.015_bb0160
  article-title: MYC and prostate cancer
  publication-title: Genes Cancer
  doi: 10.1177/1947601910379132
– volume: 13
  start-page: 497
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0650
  article-title: Tackling the cancer stem cells—what challenges do they pose?
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4253
– volume: 3
  start-page: 780
  issue: 11
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0755
  article-title: New opportunities and challenges to defeat cancer stem cells
  publication-title: Trends Cancer
  doi: 10.1016/j.trecan.2017.08.007
– volume: 12
  start-page: 468
  year: 2010
  ident: 10.1016/j.bbadis.2018.11.015_bb0200
  article-title: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2048
– volume: 5
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0495
  article-title: Physical intimacy of breast cancer cells with mesenchymal stem cells elicits trastuzumab resistance through Src activation
  publication-title: Sci. Rep.
  doi: 10.1038/srep13744
– volume: 10
  start-page: 583
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0130
  article-title: BMI-1, a promising therapeutic target for human cancer
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2015.3361
– volume: 16
  start-page: 225
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0475
  article-title: The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.02.015
– volume: 2
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0675
  article-title: Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase
  publication-title: Oncoimmunology
  doi: 10.4161/onci.27231
– volume: 67
  start-page: 7
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0010
  article-title: Cancer statistics, 2017
  publication-title: CA Cancer J. Clin.
– year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0660
  article-title: A promising new approach to cancer therapy: targeting iron metabolism in cancer stem cells
– volume: 138
  start-page: 1698
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0170
  article-title: Ep CAM expression in breast cancer cells is associated with enhanced bone metastasis formation
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.29921
– volume: 18
  start-page: 757
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0570
  article-title: Cancer stem cells in lung cancer: evidence and controversies
  publication-title: Respirology
  doi: 10.1111/resp.12094
– volume: 7
  start-page: 1554
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0255
  article-title: Hedgehog signaling in the maintenance of cancer stem cells
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers7030851
– volume: 11
  start-page: 284
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0410
  article-title: 5-Fluorouracil chemotherapy of gastric cancer generates residual cells with properties of cancer stem cells
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.10248
– volume: 18
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0115
  article-title: ABC transporters in cancer stem cells: beyond chemoresistance
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18112362
– volume: 10
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0480
  article-title: Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer
  publication-title: PLoS One
– volume: 121
  start-page: 1703
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0025
  article-title: Cancer treatments and their side effects are associated with aggravation of insomnia: results of a longitudinal study
  publication-title: Cancer
  doi: 10.1002/cncr.29244
– volume: 17
  start-page: 648
  year: 2016
  ident: 10.1016/j.bbadis.2018.11.015_bb0295
  article-title: miR-10b expression in breast cancer stem cells supports self-renewal through negative PTEN regulation and sustained AKT activation
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201540678
– volume: 113
  start-page: 4341
  year: 2009
  ident: 10.1016/j.bbadis.2018.11.015_bb0510
  article-title: CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
  publication-title: Blood
  doi: 10.1182/blood-2008-10-186668
– volume: 153
  start-page: 209
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0190
  article-title: Wnt signaling in stem cells and cancer stem cells: a tale of two coactivators
  publication-title: Prog. Mol. Biol. Transl. Sci.
  doi: 10.1016/bs.pmbts.2017.11.007
– volume: 77
  start-page: 1439
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0230
  article-title: Constitutive NOTCH3 signaling promotes the growth of basal breast cancers
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-1022
– volume: 68
  start-page: 7
  year: 2018
  ident: 10.1016/j.bbadis.2018.11.015_bb0005
  article-title: Cancer statistics, 2018
  publication-title: CA Cancer J. Clin.
– volume: 4
  start-page: 64
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0280
  article-title: Targeting PI3K/Akt/mTOR signaling in cancer
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2014.00064
– volume: 36
  start-page: 38
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0045
  article-title: Cancer metastasis: issues and challenges
  publication-title: Chin. J. Cancer
  doi: 10.1186/s40880-017-0206-7
– volume: 77
  start-page: 6641
  issue: 23
  year: 2017
  ident: 10.1016/j.bbadis.2018.11.015_bb0155
  article-title: MYC inhibition depletes cancer stem-like cells in triple-negative breast cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-3452
– volume: 122
  start-page: 3335
  year: 2013
  ident: 10.1016/j.bbadis.2018.11.015_bb0310
  article-title: Autocrine TNF-alpha production supports CML stem and progenitor cell survival and enhances their proliferation
  publication-title: Blood
  doi: 10.1182/blood-2013-02-485607
– volume: 22
  start-page: 457
  year: 2012
  ident: 10.1016/j.bbadis.2018.11.015_bb0350
  article-title: Understanding cancer stem cell heterogeneity and plasticity
  publication-title: Cell Res.
  doi: 10.1038/cr.2012.13
– volume: 8
  start-page: 142
  year: 2014
  ident: 10.1016/j.bbadis.2018.11.015_bb0460
  article-title: ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2013.10.007
– volume: 432
  start-page: 396
  year: 2004
  ident: 10.1016/j.bbadis.2018.11.015_bb0090
  article-title: Identification of human brain tumour initiating cells
  publication-title: Nature
  doi: 10.1038/nature03128
– volume: 13
  start-page: 823
  year: 2009
  ident: 10.1016/j.bbadis.2018.11.015_bb0145
  article-title: Targeting CD133 antigen in cancer
  publication-title: Expert Opin. Ther. Targets
  doi: 10.1517/14728220903005616
– volume: 56
  start-page: 414
  year: 2015
  ident: 10.1016/j.bbadis.2018.11.015_bb0550
  article-title: Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity
  publication-title: Connect. Tissue Res.
  doi: 10.3109/03008207.2015.1066780
SSID ssj0000670
Score 2.5862882
SecondaryResourceType review_article
Snippet Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived and generate cellular progeny throughout life. Cancer stem...
Unlike other normal cells, a subpopulation of cells often termed as "stem cells" are long-lived and generate cellular progeny throughout life. Cancer stem...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 165339
SubjectTerms Cancer stem cells
Immune-modulation
Pathways affecting stem cells
Radio- and chemoresistance
Title Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance
URI https://dx.doi.org/10.1016/j.bbadis.2018.11.015
https://www.ncbi.nlm.nih.gov/pubmed/30481586
https://www.proquest.com/docview/2138642479
Volume 1866
WOSCitedRecordID wos000515209600007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: Elsevier SD Freedom Collection Journals 2021
  customDbUrl:
  eissn: 1879-260X
  dateEnd: 20210131
  omitProxy: false
  ssIdentifier: ssj0000670
  issn: 0925-4439
  databaseCode: AIEXJ
  dateStart: 19950125
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbKBmIvCMZl5TIFibcoVS5u4_BWVUOAYEKoQN8i23HUlC6Z2nQa_4qfyDmxnWaDMfbASxSlJ5GT89Xn4nM-E_JKgcshIqYwBzD0aC5CL5GJ8BIGpzTmwVA2PLMf4uNjNpsln3q9n7YX5mwZlyU7P09O_6uq4RooG1tnb6Du9qFwAc5B6XAEtcPxnxQ_QT2uXCRodjEtr2veKp4ZN9O2W7kQaKPzaFsG1rVljUBBrOyE0amO1IX136KS8wKpBlxVu6KodIaEIzcHH8BMYTbddcFKasaTSytBH_l3pdvRcFZZz93P_GS75lQudF52vKzaTqLpvFhtTviyuekrL4tWXGXaUoxXGwG_m5Y1k8oI_U4FjMlJhoAXqtmNttOz3pbFAJF2ZttgBM5q8kdDoHMSi4EQHN4PS_jYANlade_oRd7tS_awrVK0BXCLVD8lxadAyJT6yGqwG8bDBEzB7vjd0ex91_o3eT37KrZds6kp_H00V7lDV4U7jdszvU_umXjFGWucPSA9Ve6TO3oH0x_75O7Ebhj4kHzTyHMQeU6DvNcO4s6pK6eDO2eLKAdw52xxh4IWdx2pR-TLm6Pp5K1n9u3wJASztSc5E2ykMhpKCa4PuJQZeLl5BgZNBaHwaUZF7vt5GPp5EHBwoZVMsMmaKUVH2Sh6THbKqlQHxMninHKZDTMfk5VIrhdCzE2DPBR5rnzVJ5H9fKk0pPa4t8oy_Zvy-sRr7zrVpC7XyMdWM6lxTLXDmQLcrrnzpVVkCtrAb89LVW1AKIgYxP40TvrkidZwO5aoIXFio6c3HOczsrf9Wz0nO_Vqo16Q2_KsLtarQ3IrnrFDg9dfruXHZA
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cancer+stem+cells%3A+Road+to+therapeutic+resistance+and+strategies+to+overcome+resistance&rft.jtitle=Biochimica+et+biophysica+acta.+Molecular+basis+of+disease&rft.au=Makena%2C+Monish+Ram&rft.au=Ranjan%2C+Alok&rft.au=Thirumala%2C+Vani&rft.au=Reddy%2C+Arubala+P&rft.date=2020-04-01&rft.issn=0925-4439&rft.volume=1866&rft.issue=4&rft.spage=165339&rft_id=info:doi/10.1016%2Fj.bbadis.2018.11.015&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bbadis_2018_11_015
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0925-4439&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0925-4439&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0925-4439&client=summon