The expression profile and role of non-coding RNAs in obesity

Latest years have experienced a dramatic upsurge in the knowledge about the function of non-coding transcripts in the determination of diverse human phenotypes including obesity. Several miRNAs and lncRNAs participate in the regulation of metabolic pathways leading to obesity. Several lncRNAs such a...

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Vydáno v:European journal of pharmacology Ročník 892; s. 173809
Hlavní autoři: Ghafouri-Fard, Soudeh, Taheri, Mohammad
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 05.02.2021
Témata:
Adipogenesis - genetics
Adiposity - genetics
Animals
Energy Metabolism - genetics
Expression profile
Gene Expression Regulation
Humans
lncRNA
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Non-coding RNAs
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - physiopathology
RNA, Circular - genetics
RNA, Circular - metabolism
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Transcriptome
Obesity
Non-coding RNAs
miRNA
Expression profile
lncRNA
ISSN:0014-2999, 1879-0712, 1879-0712
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Popis
Shrnutí:Latest years have experienced a dramatic upsurge in the knowledge about the function of non-coding transcripts in the determination of diverse human phenotypes including obesity. Several miRNAs and lncRNAs participate in the regulation of metabolic pathways leading to obesity. Several lncRNAs such as Mist, lincIRS2, lncRNA-p5549, H19, GAS5 and SNHG9 have been shown to be down-regulated in adipose tissues or other biological samples in the obese human or animal subjects. On the other hand, Meg3, Plnc1, Blnc1, AC092834.1, TINCR and PVT1 are among up-regulated lncRNAs in the obese subjects. Tens of miRNAs have differential expression between obese and non-obese subjects or between mature adipocytes and pre-adipocytes. Understanding the molecular mechanism of involvement of non-coding RNAs in the pathobiology of obesity would simplify design of therapeutic choices for protecting against obesity and its related comorbidities. We explain the available literature on the function of these transcripts in the pathobiology of obesity. •Numerous miRNAs, circRNAs and linear lncRNAs participate in the regulation of metabolic pathways leading to obesity.•Meg3, Plnc1, Blnc1, AC092834.1, TINCR and PVT1 are among up-regulated lncRNAs in the obese subjects.•Tens of miRNAs have differential expression between obese and non-obese subjects or between mature adipocytes and pre-adipocytes.•Understanding the ceRNA network would simplify design of therapeutic choices for protecting against obesity and its related comorbidities.
Bibliografie:ObjectType-Article-1
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ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2020.173809