Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis

Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivi...

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Bibliographic Details
Published in:Multiple sclerosis Vol. 20; no. 8; pp. 1050 - 1057
Main Authors: Basile, B, Castelli, M, Monteleone, F, Nocentini, U, Caltagirone, C, Centonze, D, Cercignani, M, Bozzali, M
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01.07.2014
Sage Publications
Sage Publications Ltd
Subjects:
Adult
Aged
Biological and medical sciences
Brain - diagnostic imaging
Brain - physiopathology
Brain Mapping - methods
Case-Control Studies
Cognition
Cross-Sectional Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disability Evaluation
Female
Humans
Immunomodulators
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Motor Activity
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Multiple Sclerosis, Chronic Progressive - diagnostic imaging
Multiple Sclerosis, Chronic Progressive - physiopathology
Multiple Sclerosis, Chronic Progressive - psychology
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Multiple Sclerosis, Relapsing-Remitting - psychology
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neurology
Neuropsychological Tests
Pharmacology. Drug treatments
Phenotype
Sensory Thresholds
Severity of Illness Index
Young Adult
resting-state functional magnetic resonance imaging
functional connectivity
secondary progressive multiple sclerosis
Relapsing–remitting multiple sclerosis
Nervous system diseases
Multiple sclerosis
Nuclear magnetic resonance imaging
Inflammatory disease
Central nervous system disease
Relapsing-remitting multiple sclerosis
Medical imagery
Evolution
Degenerative disease
Functional imaging
ISSN:1352-4585, 1477-0970, 1477-0970
Online Access:Get full text
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Summary:Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks. Objective: RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions. Methods: Thirty-four relapsing–remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes. Results: Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups. Conclusions: FC changes seem to parallel patients’ clinical state and capability of compensating for the severity of clinical/cognitive disabilities.
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ISSN:1352-4585
1477-0970
1477-0970
DOI:10.1177/1352458513515082