Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis
Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivi...
Saved in:
| Published in: | Multiple sclerosis Vol. 20; no. 8; pp. 1050 - 1057 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London, England
SAGE Publications
01.07.2014
Sage Publications Sage Publications Ltd |
| Subjects: | |
| ISSN: | 1352-4585, 1477-0970, 1477-0970 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background:
In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks.
Objective:
RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions.
Methods:
Thirty-four relapsing–remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes.
Results:
Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups.
Conclusions:
FC changes seem to parallel patients’ clinical state and capability of compensating for the severity of clinical/cognitive disabilities. |
|---|---|
| AbstractList | In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks.
RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions.
Thirty-four relapsing-remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes.
Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups.
FC changes seem to parallel patients' clinical state and capability of compensating for the severity of clinical/cognitive disabilities. In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks.BACKGROUNDIn multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks.RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions.OBJECTIVERS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions.Thirty-four relapsing-remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes.METHODSThirty-four relapsing-remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes.Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups.RESULTSIncreased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups.FC changes seem to parallel patients' clinical state and capability of compensating for the severity of clinical/cognitive disabilities.CONCLUSIONSFC changes seem to parallel patients' clinical state and capability of compensating for the severity of clinical/cognitive disabilities. Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks. Objective: RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions. Methods: Thirty-four relapsingremitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes. Results: Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups. Conclusions: FC changes seem to parallel patients clinical state and capability of compensating for the severity of clinical/cognitive disabilities. Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major pathophysiological mechanism. Resting-state (RS) functional magnetic resonance imaging (fMRI) is believed to reflect brain functional connectivity (FC) within specific neuronal networks. Objective: RS-fMRI was used to investigate changes in FC within two critical networks for the understanding of MS disabilities, namely, the sensory-motor network (SMN) and the default-mode network (DMN), respectively, implicated in sensory-motor and cognitive functions. Methods: Thirty-four relapsing–remitting (RR), 14 secondary progressive (SP) MS patients and 25 healthy controls underwent MRI at 3T, including conventional images, T1-weighted volumes, and RS-fMRI sequences. Independent component analysis (ICA) was employed to extract maps of the relevant RS networks for every participant. Group analyses were performed to assess changes in FC within the SMN and DMN in the two MS phenotypes. Results: Increased FC was found in both networks of MS patients. Interestingly, specific changes in either direction were observed also between RR and SP MS groups. Conclusions: FC changes seem to parallel patients’ clinical state and capability of compensating for the severity of clinical/cognitive disabilities. |
| Author | Basile, B Castelli, M Cercignani, M Bozzali, M Monteleone, F Caltagirone, C Nocentini, U Centonze, D |
| Author_xml | – sequence: 1 givenname: B surname: Basile fullname: Basile, B – sequence: 2 givenname: M surname: Castelli fullname: Castelli, M – sequence: 3 givenname: F surname: Monteleone fullname: Monteleone, F – sequence: 4 givenname: U surname: Nocentini fullname: Nocentini, U – sequence: 5 givenname: C surname: Caltagirone fullname: Caltagirone, C – sequence: 6 givenname: D surname: Centonze fullname: Centonze, D – sequence: 7 givenname: M surname: Cercignani fullname: Cercignani, M – sequence: 8 givenname: M surname: Bozzali fullname: Bozzali, M email: m.bozzali@hsantalucia.it |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28578106$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24326671$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1rFTEUxYO02A_du5KACG5GcyfJJLOUYlUouGnXQ5LJ9KXmJWOSael_b4b3qvJAXd2E-zsH7jln6CjEYBF6BeQ9gBAfgPKWccnrBE5k-wydAhOiIb0gR_Vd1826P0FnOd8RQoSg_Dk6aRltu07AKQqXSzDFxaA8NjEEWz_3rjxis1Hh1mb84MrGBZxna9zkDA62PMT0PeNZJeW99bhsLDbeBWeqh72Pfln9cJzwdvHFzd7ibLxNMbv8Ah1Pymf7cj_P0c3lp-uLL83Vt89fLz5eNYa1sjQaRmkmQoW2IHTHezZSrrRh2mhu2AigdDtqMtEOFKGGQS-6UWlKOQGqgJ6jdzvfOcUfi81l2LpsrPcq2LjkAWTNggCH_v9oJyllUjJZ0TcH6F1cUo2uUpwJ2bfQroav99Sit3Yc5uS2Kj0OT6FX4O0eULlmNiUVjMu_OcmFBNJVjuw4U7PLyU6_ECDD2v9w2H-VdAcS44pa-yhJOf8vYbMTZnVr_zjrb_xP1iq_0w |
| CitedBy_id | crossref_primary_10_1089_brain_2021_0104 crossref_primary_10_3389_fneur_2018_00690 crossref_primary_10_3389_fneur_2018_00828 crossref_primary_10_1371_journal_pone_0210375 crossref_primary_10_1136_jnnp_2017_316329 crossref_primary_10_1177_1352458518788218 crossref_primary_10_1177_1352458519861597 crossref_primary_10_1016_j_clinph_2015_05_029 crossref_primary_10_1162_IMAG_a_51 crossref_primary_10_1177_13524585211018116 crossref_primary_10_1177_13524585211030212 crossref_primary_10_3390_neurolint14020042 crossref_primary_10_1523_JNEUROSCI_2557_14_2015 crossref_primary_10_3389_fnhum_2022_852981 crossref_primary_10_1007_s11682_016_9551_4 crossref_primary_10_1155_2015_212693 crossref_primary_10_1016_j_sleep_2019_01_010 crossref_primary_10_1002_hbm_23307 crossref_primary_10_1038_s43856_023_00319_4 crossref_primary_10_1080_00325481_2019_1663706 crossref_primary_10_1016_j_brainresbull_2025_111278 crossref_primary_10_3389_fneur_2023_1250894 crossref_primary_10_1007_s11682_015_9476_3 crossref_primary_10_1016_j_msard_2021_102923 crossref_primary_10_1016_j_nicl_2022_103127 crossref_primary_10_1177_1545968315593809 crossref_primary_10_1007_s12035_017_0598_z crossref_primary_10_2174_0929867326666191014162713 crossref_primary_10_1093_cercor_bhad535 crossref_primary_10_1016_j_neuroscience_2017_10_033 crossref_primary_10_3389_fnins_2021_763966 crossref_primary_10_1177_1352458518813108 |
| Cites_doi | 10.1002/(SICI)1097-0193(1999)8:2/3<151::AID-HBM13>3.0.CO;2-5 10.1093/brain/awn018 10.1093/brain/122.5.871 10.1162/08989290051137585 10.1148/radiol.2241011005 10.1007/s10072-011-0636-y 10.1196/annals.1340.028 10.1038/nrn2201 10.1006/nimg.2000.0654 10.1073/pnas.0704320104 10.1016/j.neurobiolaging.2011.10.031 10.1016/S0022-510X(99)00113-6 10.1002/mrm.1910340409 10.1038/jcbfm.1993.4 10.1001/archneur.59.10.1565 10.1177/135245859900500409 10.1152/jn.1989.61.5.900 10.1093/brain/awq058 10.1212/WNL.0b013e3181d9ed91 10.1016/S1053-8119(96)80259-X 10.1080/13576500903081806 10.1007/s100720200003 10.1371/journal.pone.0052660 10.1098/rstb.2005.1634 10.1177/1352458506070933 10.1038/35094500 10.1136/jnnp.2009.199935 10.1073/pnas.0135058100 10.1073/pnas.0601417103 10.1177/1352458510394609 10.1002/ana.1032 10.1016/j.neubiorev.2013.03.006 10.1006/nimg.2001.0786 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2013 2015 INIST-CNRS The Author(s) 2013. SAGE Publications © Jul 2014 |
| Copyright_xml | – notice: The Author(s) 2013 – notice: 2015 INIST-CNRS – notice: The Author(s) 2013. – notice: SAGE Publications © Jul 2014 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7T5 7TK 7U9 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU FYUFA GHDGH H94 K9- K9. M0R M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 7X8 |
| DOI | 10.1177/1352458513515082 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Neurosciences Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts Consumer Health Database ProQuest Health & Medical Complete (Alumni) Consumer Health Database ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Family Health (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1477-0970 |
| EndPage | 1057 |
| ExternalDocumentID | 3382498031 24326671 28578106 10_1177_1352458513515082 10.1177_1352458513515082 |
| Genre | Journal Article Comparative Study Feature |
| GroupedDBID | --- -TM .2E .2F .2G .2J .2N 01A 0R~ 123 18M 1~K 29M 31R 31S 31U 31X 31Y 31Z 36B 39C 4.4 53G 54M 5VS 7X7 88E 8FI 8FJ 8R4 8R5 AABMB AABOD AACKU AACMV AACTG AADUE AAEWN AAGGD AAGLT AAGMC AAJIQ AAJOX AAJPV AAKGS AANSI AAPEO AAQDB AAQXH AAQXI AARDL AARIX AATAA AATBZ AAUAS AAXOT AAYTG AAZBJ ABAFQ ABAWC ABAWP ABCCA ABCJG ABDWY ABEIX ABFWQ ABHFT ABHKI ABHQH ABIDT ABJIS ABJNI ABJZC ABKRH ABLUO ABNCE ABPGX ABPNF ABQKF ABQXT ABRHV ABUJY ABUWG ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFO ACGFS ACGZU ACJER ACJTF ACLFY ACLHI ACLZU ACNXM ACOFE ACOXC ACPRK ACROE ACRPL ACSIQ ACUAV ACUIR ACXKE ACXMB ADBBV ADDLC ADEBD ADEIA ADMPF ADNBR ADNMO ADNON ADRRZ ADSTG ADTBJ ADUCT ADUKL ADVBO ADYCS ADZYD ADZZY AECGH AECVZ AEDTQ AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRA AFKRG AFMOU AFQAA AFUIA AFVCE AFWMB AGHKR AGKLV AGNHF AGPXR AGQPQ AGWFA AGWNL AHDMH AHHFK AHMBA AIGRN AJABX AJEFB AJMMQ AJSCY AJUZI AJXAJ AJXGE ALIPV ALKWR ALMA_UNASSIGNED_HOLDINGS AMCVQ ANDLU ARTOV ASPBG AUTPY AVWKF AYAKG AZFZN AZQEC B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BENPR BKIIM BKNYI BKSCU BPACV BPHCQ BSEHC BVXVI BWJAD BYIEH CAG CBRKF CCPQU CDWPY CFDXU COF CORYS CQQTX CS3 CUTAK DB0 DC- DC0 DD- DD0 DE- DF0 DO- DOPDO DU5 DV7 DV9 D~Y EBS EJD EMOBN F5P FD6 FEDTE FHBDP FYUFA GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HF~ HMCUK HVGLF HZ~ J8X K.F K.J K9- M0R M1P N9A O9- P.B P2P PHGZM PHGZT PQQKQ PROAC PSQYO Q1R Q2X Q7K Q7L Q7R Q7U Q7X Q82 Q83 ROL S01 SASJQ SAUOL SCNPE SDB SFB SFC SFK SFN SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPQ SPV SQCSI STM UKHRP XJT ZONMY ZPPRI ZRKOI ZSSAH 0SE AAEJI AAPII AAYXX ABUAX AFFHD AJGYC AJHME AJVBE CITATION PJZUB PPXIY ALTZF IQODW M4V CGR CUY CVF ECM EIF NPM 3V. 7T5 7TK 7U9 7XB 8FK H94 K9. PKEHL PQEST PQUKI 7X8 PUEGO |
| ID | FETCH-LOGICAL-c428t-b1d8cf037be17b6594d35abc4bcb5c4d11ab2db0f361a03c41976dab335013a13 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 40 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000338819400006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1352-4585 1477-0970 |
| IngestDate | Wed Oct 01 14:30:51 EDT 2025 Sun Nov 09 10:31:59 EST 2025 Mon Oct 06 17:46:42 EDT 2025 Thu Apr 03 07:09:09 EDT 2025 Wed Apr 02 07:46:50 EDT 2025 Sat Nov 29 08:11:45 EST 2025 Tue Nov 18 22:19:35 EST 2025 Tue Jun 17 22:30:45 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | resting-state functional magnetic resonance imaging functional connectivity secondary progressive multiple sclerosis Relapsing–remitting multiple sclerosis Nervous system diseases Multiple sclerosis Nuclear magnetic resonance imaging Inflammatory disease Central nervous system disease Relapsing-remitting multiple sclerosis Medical imagery Evolution Degenerative disease Functional imaging |
| Language | English |
| License | CC BY 4.0 The Author(s) 2013. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c428t-b1d8cf037be17b6594d35abc4bcb5c4d11ab2db0f361a03c41976dab335013a13 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 |
| PMID | 24326671 |
| PQID | 1547892129 |
| PQPubID | 38324 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1800701519 proquest_miscellaneous_1683348848 proquest_journals_1547892129 pubmed_primary_24326671 pascalfrancis_primary_28578106 crossref_primary_10_1177_1352458513515082 crossref_citationtrail_10_1177_1352458513515082 sage_journals_10_1177_1352458513515082 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-07-01 |
| PublicationDateYYYYMMDD | 2014-07-01 |
| PublicationDate_xml | – month: 07 year: 2014 text: 2014-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London, England |
| PublicationPlace_xml | – name: London, England – name: London – name: England |
| PublicationTitle | Multiple sclerosis |
| PublicationTitleAlternate | Mult Scler |
| PublicationYear | 2014 |
| Publisher | SAGE Publications Sage Publications Sage Publications Ltd |
| Publisher_xml | – name: SAGE Publications – name: Sage Publications – name: Sage Publications Ltd |
| References | Bonavita, Gallo, Sacco 2011; 17 Gusnard, Raichle 2001; 2 McDonald, Compstonm, Edanm 2001; 50 Cutter, Baier, Rudick 1999; 122 Rey 1941; 28 Cabeza, Nyberg 2000; 12 Greicius, Krasnow, Reiss 2003; 100 Friston, Frith, Liddle 1993; 13 Rovaris, Bozzali, Rodegher 1999; 166 Lowe, Mock, Sorenson 1996; 3 Good, Johnsrude, Ashburner 2001; 14 Lowe, Phillips, Lurito 2002; 224 Lansley, Mataix-Cols, Grau 2013; 37 Busch, Hagemann, Bender 2010; 15 Rocca, Valsasina, Absinta 2010; 74 Aertsen, Gerstein, Habib, Palm 1989; 61 Biswal, Yetkin, Haughton 1995; 34 De Stefano, Narayanan, Francis 2002; 59 Damoiseaux, Rombouts, Barkhof 2006; 103 Xiong, Parsons, Gao 1999; 8 Liu, Liang, Zhou 2008; 131 Amato 2006; 12 Koch, Bozzali, Bonnì 2012; 7 Borroni, Alberici, Cercignani 2012; 33 Filley 2005; 1064 Lowe, Dzemidzic, Lurito 2000; 2 Beckmann, DeLuca, Devlin 2005; 360 Fischer, Rudick, Cutter 1999; 5 Rosazza, Minati 2011; 32 Fox, Raichle 2007; 8 Gili, Cercignani, Serra 2011; 82 Caffarra, Vezzadini, Dieci 2002; 22 Roosendaal, Schoonheim, Hulst 2010; 133 Dosenbach, Fair, Miezin 2007; 104 bibr15-1352458513515082 Rey A (bibr30-1352458513515082) 1941; 28 bibr32-1352458513515082 bibr1-1352458513515082 bibr29-1352458513515082 bibr7-1352458513515082 bibr10-1352458513515082 bibr23-1352458513515082 bibr27-1352458513515082 bibr14-1352458513515082 bibr8-1352458513515082 bibr31-1352458513515082 bibr13-1352458513515082 bibr35-1352458513515082 bibr22-1352458513515082 bibr4-1352458513515082 bibr9-1352458513515082 bibr21-1352458513515082 bibr26-1352458513515082 bibr34-1352458513515082 bibr18-1352458513515082 bibr17-1352458513515082 Smith A (bibr28-1352458513515082) 2000 bibr12-1352458513515082 bibr5-1352458513515082 bibr25-1352458513515082 bibr3-1352458513515082 bibr33-1352458513515082 bibr16-1352458513515082 bibr19-1352458513515082 bibr24-1352458513515082 bibr6-1352458513515082 bibr11-1352458513515082 bibr20-1352458513515082 bibr2-1352458513515082 |
| References_xml | – volume: 166 start-page: 58 year: 1999 end-page: 63 article-title: Brain MRI correlates of magnetization transfer imaging in patients with multiple sclerosis publication-title: J Neurol Sci – volume: 1064 start-page: 162 year: 2005 end-page: 183 article-title: White matter and behavioral neurology publication-title: An New York Ac Sci – volume: 131 start-page: 945 year: 2008 end-page: 961 article-title: Disrupted small-world networks in schizophrenia publication-title: Brain – volume: 2 start-page: 582 year: 2000 end-page: 587 article-title: Correlations in low-frequency BOLD fluctuations reflect cortico-cortical connections publication-title: Neuroimage – volume: 17 start-page: 411 year: 2011 end-page: 422 article-title: Distributed changes in default-mode resting-state connectivity in multiple sclerosis publication-title: Mult Scler – volume: 7 start-page: e52660 year: 2012 article-title: fMRI resting slow fluctuations correlate with the activity of fast cortico-cortical physiological connections publication-title: PLoS One – volume: 74 start-page: 1252 year: 2010 end-page: 1259 article-title: Default-mode network dysfunction and cognitive impairment in progressive MS publication-title: Neurology – volume: 104 start-page: 11073 year: 2007 end-page: 11078 article-title: Distinct brain networks for adaptive and stable task control in humans publication-title: Proc Natl Acad Sci USA – volume: 61 start-page: 900 year: 1989 end-page: 917 article-title: Dynamics of neuronal firing correlation: Modulation of ‘effective connectivity’ publication-title: J Neurophysiol – volume: 12 start-page: 1 year: 2000 end-page: 47 article-title: Imaging cognition, II: An empirical review of 275 PET and fMRI studies publication-title: J Cogn Neurosci – volume: 3 start-page: S257 year: 1996 article-title: Resting state fMRI signal correlations in multi-slice EPI publication-title: Neuroimage – volume: 14 start-page: 21 year: 2001 end-page: 36 article-title: A voxel-based morphometric study of ageing in 465 normal adult human brains publication-title: Neuroimage – volume: 100 start-page: 253 year: 2003 end-page: 258 article-title: Functional connectivity in the resting brain: A network analysis of the default mode hypothesis publication-title: Proc Natl Acad Sci USA – volume: 32 start-page: 773 year: 2011 end-page: 785 article-title: Resting-state brain networks: Literature review and clinical applications publication-title: Neurol Sci – volume: 122 start-page: 871 year: 1999 end-page: 882 article-title: J. Development of a multiple sclerosis functional composite as a clinical trial outcome measure publication-title: Brain – volume: 28 start-page: 286 year: 1941 end-page: 340 article-title: L’examen psychologique dans les cas d’encèphalopathie traumatique publication-title: Archives de Psychologie – volume: 12 start-page: 787 year: 2006 end-page: 793 article-title: The Rao’s Brief Repeatable Battery and Stroop Test: Normative values with age, education and gender corrections in an Italian population publication-title: Mult Scler – volume: 59 start-page: 1565 year: 2002 end-page: 1571 article-title: Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability publication-title: Arch Neurol – volume: 8 start-page: 151 year: 1999 end-page: 156 article-title: Interregional connectivity to primary motor cortex revealed using MRI resting state images publication-title: Hum Brain Mapp – volume: 82 start-page: 58 year: 2011 end-page: 66 article-title: Regional brain atrophy and functional disconnection across Alzheimer’s disease evolution publication-title: J Neurol Neurosurg Psychiatr – volume: 13 start-page: 5 year: 1993 end-page: 14 article-title: Functional connectivity: The principal-component analysis of large (PET) data sets publication-title: J Cereb Blood Flow Metab – volume: 15 start-page: 610 year: 2010 end-page: 628 article-title: The dimensionality of the Edinburgh Handedness Inventory: An analysis with models of the item response theory publication-title: Laterality – volume: 5 start-page: 244 year: 1999 end-page: 250 article-title: The multiple sclerosis functional composite measure (MSFC): An integrated approach to MS clinical outcome assessment. National MS society clinical outcomes assessment task force publication-title: Mult Scler – volume: 50 start-page: 121 year: 2001 end-page: 127 article-title: Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis publication-title: Ann Neurol – volume: 103 start-page: 13848 year: 2006 end-page: 13853 article-title: Consistent resting-state networks across healthy subjects publication-title: Proc Natl Acad Sci USA – volume: 133 start-page: 1612 year: 2010 end-page: 1221 article-title: Resting state networks change in clinically isolated syndrome publication-title: Brain – volume: 33 start-page: 2506 year: 2012 end-page: 2520 article-title: Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD publication-title: Neurobiol Aging – volume: 360 start-page: 1001 year: 2005 end-page: 1013 article-title: Investigations into resting-state connectivity using independent component analysis publication-title: Philos Trans R Soc Lond B Biol Sci – volume: 224 start-page: 184 year: 2002 end-page: 192 article-title: Multiple sclerosis: Low-frequency temporal blood oxygen level-dependent fluctuations indicate reduced functional connectivity initial results publication-title: Radiology – volume: 34 start-page: 537 year: 1995 end-page: 541 article-title: Functional connectivity in the motor cortex of resting human brain using echo-planar MRI publication-title: Magn Reson Med – volume: 37 start-page: 819 year: 2013 end-page: 830 article-title: Localized grey matter atrophy in multiple sclerosis: A meta-analysis of voxel-based morphometry studies and associations with functional disability publication-title: Neurosci Biobehav Rev – volume: 22 start-page: 443 year: 2002 end-page: 7 article-title: Rey-Osterrieth complex figure: normative values in an Italian population sample publication-title: Neurol Sci – volume: 2 start-page: 685 year: 2001 end-page: 694 article-title: Searching for a baseline: Functional imaging and the resting human brain publication-title: Nat Rev Neurosci – volume: 8 start-page: 700 year: 2007 end-page: 711 article-title: Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging publication-title: Nat Rev Neurosci – ident: bibr19-1352458513515082 doi: 10.1002/(SICI)1097-0193(1999)8:2/3<151::AID-HBM13>3.0.CO;2-5 – ident: bibr24-1352458513515082 doi: 10.1093/brain/awn018 – ident: bibr29-1352458513515082 doi: 10.1093/brain/122.5.871 – ident: bibr35-1352458513515082 doi: 10.1162/08989290051137585 – ident: bibr20-1352458513515082 doi: 10.1148/radiol.2241011005 – volume-title: Symbol digit modalities test, manual year: 2000 ident: bibr28-1352458513515082 – ident: bibr14-1352458513515082 doi: 10.1007/s10072-011-0636-y – ident: bibr2-1352458513515082 doi: 10.1196/annals.1340.028 – ident: bibr11-1352458513515082 doi: 10.1038/nrn2201 – ident: bibr8-1352458513515082 doi: 10.1006/nimg.2000.0654 – ident: bibr18-1352458513515082 doi: 10.1073/pnas.0704320104 – ident: bibr16-1352458513515082 doi: 10.1016/j.neurobiolaging.2011.10.031 – volume: 28 start-page: 286 year: 1941 ident: bibr30-1352458513515082 publication-title: Archives de Psychologie – ident: bibr1-1352458513515082 doi: 10.1016/S0022-510X(99)00113-6 – ident: bibr6-1352458513515082 doi: 10.1002/mrm.1910340409 – ident: bibr7-1352458513515082 doi: 10.1038/jcbfm.1993.4 – ident: bibr4-1352458513515082 doi: 10.1001/archneur.59.10.1565 – ident: bibr27-1352458513515082 doi: 10.1177/135245859900500409 – ident: bibr5-1352458513515082 doi: 10.1152/jn.1989.61.5.900 – ident: bibr23-1352458513515082 doi: 10.1093/brain/awq058 – ident: bibr21-1352458513515082 doi: 10.1212/WNL.0b013e3181d9ed91 – ident: bibr9-1352458513515082 doi: 10.1016/S1053-8119(96)80259-X – ident: bibr26-1352458513515082 doi: 10.1080/13576500903081806 – ident: bibr33-1352458513515082 doi: 10.1007/s100720200003 – ident: bibr34-1352458513515082 doi: 10.1371/journal.pone.0052660 – ident: bibr17-1352458513515082 doi: 10.1098/rstb.2005.1634 – ident: bibr31-1352458513515082 doi: 10.1177/1352458506070933 – ident: bibr13-1352458513515082 doi: 10.1038/35094500 – ident: bibr15-1352458513515082 doi: 10.1136/jnnp.2009.199935 – ident: bibr12-1352458513515082 doi: 10.1073/pnas.0135058100 – ident: bibr10-1352458513515082 doi: 10.1073/pnas.0601417103 – ident: bibr22-1352458513515082 doi: 10.1177/1352458510394609 – ident: bibr25-1352458513515082 doi: 10.1002/ana.1032 – ident: bibr3-1352458513515082 doi: 10.1016/j.neubiorev.2013.03.006 – ident: bibr32-1352458513515082 doi: 10.1006/nimg.2001.0786 |
| SSID | ssj0007735 |
| Score | 2.2812626 |
| Snippet | Background:
In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major... In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major... Background: In multiple sclerosis (MS), the location of focal lesions does not always correlate with clinical symptoms, suggesting disconnection as a major... |
| SourceID | proquest pubmed pascalfrancis crossref sage |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1050 |
| SubjectTerms | Adult Aged Biological and medical sciences Brain - diagnostic imaging Brain - physiopathology Brain Mapping - methods Case-Control Studies Cognition Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disability Evaluation Female Humans Immunomodulators Magnetic Resonance Imaging Male Medical sciences Middle Aged Motor Activity Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Chronic Progressive - diagnostic imaging Multiple Sclerosis, Chronic Progressive - physiopathology Multiple Sclerosis, Chronic Progressive - psychology Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging Multiple Sclerosis, Relapsing-Remitting - physiopathology Multiple Sclerosis, Relapsing-Remitting - psychology Nerve Net - diagnostic imaging Nerve Net - physiopathology Neurology Neuropsychological Tests Pharmacology. Drug treatments Phenotype Sensory Thresholds Severity of Illness Index Young Adult |
| Title | Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis |
| URI | https://journals.sagepub.com/doi/full/10.1177/1352458513515082 https://www.ncbi.nlm.nih.gov/pubmed/24326671 https://www.proquest.com/docview/1547892129 https://www.proquest.com/docview/1683348848 https://www.proquest.com/docview/1800701519 |
| Volume | 20 |
| WOSCitedRecordID | wos000338819400006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1477-0970 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0007735 issn: 1352-4585 databaseCode: M0R dateStart: 19980101 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1477-0970 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0007735 issn: 1352-4585 databaseCode: 7X7 dateStart: 19980101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1477-0970 dateEnd: 20151231 omitProxy: false ssIdentifier: ssj0007735 issn: 1352-4585 databaseCode: BENPR dateStart: 19980101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Na9swFH-s6RiDsc9u9dYFDcZgBxPJki35NLbRsMMaStkgtyDrAwLByeq0f3-fIjlZxpbLLgbbkiXrPT39pPcF8J4KIZ3xOufU21wo6nNd1DRvGOVae4QMbpO15LucTNR0Wl-mA7cumVX2MnEjqO3ShDPyEQuBp2oUtPWn1a88ZI0K2tWUQuMIjkOkMjGA4y_nk8urrSyWkpc75eSIIdwQQRHGyxAHvdhbjB6tdIfj4mNCi78hzj1rr80CNH7yv11_Co8T9CSfI688g3uufQ4PLpJy_QW0Y1zj4tEgMcH-xcTMEiQ6B3cknNnOWxKcM4OBEWmjCXlHQvzwxcItCKJJ0vtaEneb2JosPekNF0mHbeNgzLsT-Dk-__H1W57SMeQG9yhrJJ9VxlMuG8dkU5W1sLzUjRGNaUojLGO6KWxDPa-YptwIhlDH6oYH3SXXjL-EQbts3SkQWml8yAtpcPsnqdW0Vlbi1qriDOWtz2DU02VmUqzykDJjMWMpPPmflMzg47bGKsbpOFB2uEfqbYVCofzCPXIGZz0hZ2lKd7MdFTN4t32NkzFoWHTrljdYplLBs1kJdaCMCiGWEGjhd15Fvtp1QCCariTL4ENgtN8a_8evvD7c0zfwEAGeiObFZzBYX9-4t3Df3K7n3fUQjuRUbq5qmCYO3l3QqztArB12 |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4aAwHSxG1cAmMYCZD2ENWOnTh5QAgB1aa1FUJD2ltwHEeqVKVl6Yb4U_zGnVMnLUXQtz3wmvjuz-cc-9wAXnGltLOVCSWvylClvApNlPGwEFwaU6HI4BZZSwZ6NEpPT7PPW_Cr84Uhs8qOJi4IdTm19EbeExR4KkNCm72bfQ8paxRpV7sUGh4Wx-7nD7yyNW-PPuL-vo6i_qeTD4dhm1UgtChqz3EUZWorLnXhhC6SOFOljE1hVWGL2KpSCFNEZcErmQjDpVUCOXZpCkkqOGmExHavwXWKq0fnasi_LCm_1jJeqUJ7AoUbRWo3GVPU9WiN9e3MTIO7UPn0GX-Tb9dsyxbsrn_3f1uoe3CnFazZe38S7sOWqx_AzWFrOrALdR85uH_4ZJase6zPm8G863PD6EV6XDNyPSXzKVZ7A_mGUXT0ycRNGMrKrPMkZe6iPbRsWrHOLJM12Dcu_rh5CF-vZLaPYLue1u4JMJ4Y_CgjbfFyq3lpeJaWGi-OiRTITaoAeh0OcttGYqeEIJNctMHX_0ROAAfLGjMfhWRD2f01aC0rRClSZ8GTAPY64OQtwWryFWoCeLn8jaSG9EemdtNzLJOk5LedqnRDmZQCSKEYie089jheDUDhXSHRIoA3BOzfOv_HVJ5uHukLuHV4Mhzkg6PR8TO4jaKs8obUe7A9Pzt3z-GGvZiPm7P9xTFl8O2q4X4J5853Dg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+connectivity+changes+within+specific+networks+parallel+the+clinical+evolution+of+multiple+sclerosis&rft.jtitle=Multiple+sclerosis&rft.au=Basile%2C+B&rft.au=Castelli%2C+M&rft.au=Monteleone%2C+F&rft.au=Nocentini%2C+U&rft.date=2014-07-01&rft.pub=SAGE+Publications&rft.issn=1352-4585&rft.eissn=1477-0970&rft.volume=20&rft.issue=8&rft.spage=1050&rft.epage=1057&rft_id=info:doi/10.1177%2F1352458513515082&rft.externalDocID=10.1177_1352458513515082 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1352-4585&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1352-4585&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1352-4585&client=summon |