4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models

•4-PBA protects LPS-induced acute lung injury and inflammation in mouse model.•4-PBA decreases the levels of ER stress and autophagy induced by LPS in vivo and in vitro.•Inhibition of autophagy by 3-MA aggravates cell injury induced by LPS, ER stress-associated autophagy may play a protective effect...

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Bibliographic Details
Published in:	Toxicology letters Vol. 271; pp. 26 - 37
Main Authors:	Zeng, Meichun, Sang, Wenhua, Chen, Sha, Chen, Ran, Zhang, Hailin, Xue, Feng, Li, Zhengmao, Liu, Yu, Gong, Yongsheng, Zhang, Hongyu, Kong, Xiaoxia
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 05.04.2017
Subjects:	Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - prevention & control ALI Animals Anti-Inflammatory Agents - pharmacology Autophagy Autophagy - drug effects Cell Line, Tumor Cytokines - metabolism Cytoprotection Disease Models, Animal Dose-Response Relationship, Drug Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Humans Inflammation Mediators - metabolism Lipopolysaccharides LPS Lung - drug effects Lung - metabolism Lung - pathology Male Mice, Inbred ICR NF-kappa B - metabolism NF-κB Phenylbutyrates - pharmacology Pneumonia - chemically induced Pneumonia - metabolism Pneumonia - pathology Pneumonia - prevention & control Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism IκB NF-κB ER stress Autophagy ALI LPS Endoplasmic reticulum stress
ISSN:	0378-4274, 1879-3169, 1879-3169
Online Access:	Get full text
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