The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

Alzheimer's disease is one of the most heritable diseases in elderly people and the most common type of dementia. In addition to the major genetic determinant of Alzheimer's disease, the APOE gene, 23 genetic variants have been associated with the disease. We assessed the effects of these...

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Veröffentlicht in:	Lancet neurology Jg. 17; H. 5; S. 434 - 444
Hauptverfasser:	van der Lee, Sven J, Wolters, Frank J, Ikram, M Kamran, Hofman, Albert, Ikram, M Arfan, Amin, Najaf, van Duijn, Cornelia M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.05.2018 Elsevier Limited
Schlagworte:	Age Age of Onset Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoproteins E - genetics Blood pressure Cohort analysis Cohort Studies Dementia Dementia - epidemiology Dementia - genetics Dementia disorders Female Genetic diversity Genotypes Geriatrics Health risk assessment Humans Male Middle Aged Netherlands - epidemiology Neurodegenerative diseases Risk Assessment - statistics & numerical data Risk factors Studies Vitamin E Netherlands
ISSN:	1474-4422, 1474-4465, 1474-4465
Online-Zugang:	Volltext
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