Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases

Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate biosynthesis. Enzymatic methods to access these key materials offer a powerful alternative to traditional chemical synthesis routes. Herein we review recent advances in the enzymatic pyrophosphorylation of glycosyl 1-phos...

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Bibliographic Details
Published in:Carbohydrate research Vol. 469; pp. 38 - 47
Main Authors: Ahmadipour, Sanaz, Beswick, Laura, Miller, Gavin J.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.11.2018
Subjects:
Enzymatic synthesis
Glycosyl-1-phosphate
Nucleotidylyltransferase
Pyrophosphorylase
Sugar-nucleotide
Enzymatic synthesis
Glycosyl-1-phosphate
Nucleotidylyltransferase
Pyrophosphorylase
Sugar-nucleotide
ISSN:0008-6215, 1873-426X, 1873-426X
Online Access:Get full text
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Summary:Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate biosynthesis. Enzymatic methods to access these key materials offer a powerful alternative to traditional chemical synthesis routes. Herein we review recent advances in the enzymatic pyrophosphorylation of glycosyl 1-phosphates for the provision of both native and modified sugar-nucleotides. [Display omitted]
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ISSN:0008-6215
1873-426X
1873-426X
DOI:10.1016/j.carres.2018.09.002