Declining Risk of Sudden Death in Heart Failure

Data were analyzed from 40,195 patients with heart failure with reduced ejection fraction enrolled in 12 clinical trials in the 1995–2014 period. Sudden-death rates declined substantially over time, a finding consistent with a cumulative effect of evidence-based medical therapy.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 377; no. 1; pp. 41 - 51
Main Authors: Shen, Li, Jhund, Pardeep S, Petrie, Mark C, Claggett, Brian L, Barlera, Simona, Cleland, John G.F, Dargie, Henry J, Granger, Christopher B, Kjekshus, John, Køber, Lars, Latini, Roberto, Maggioni, Aldo P, Packer, Milton, Pitt, Bertram, Solomon, Scott D, Swedberg, Karl, Tavazzi, Luigi, Wikstrand, John, Zannad, Faiez, Zile, Michael R, McMurray, John J.V
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 06.07.2017
Subjects:
Adult
Age Factors
Aged
Angiotensin
candesartan
Cardiac arrhythmia
cardiac death
Cardiology
Cardiovascular diseases
Cause of Death
Clinical Medicine
Clinical trials
Confounding Factors, Epidemiologic
converting-enzyme inhibitors
Death
Death, Sudden - epidemiology
Defibrillators
dysfunction
Female
Follow-Up Studies
General & Internal Medicine
Health risk assessment
Heart diseases
Heart failure
Heart Failure - mortality
Heart Failure - physiopathology
Humans
implantable cardioverter-defibrillator
Incidence
Ischemia
Klinisk medicin
Male
metaanalysis
Middle Aged
Mortality
myocardial-infarction
Patients
Peptidyl-dipeptidase A
prevention
Randomized Controlled Trials as Topic
randomized controlled-trials
Regression Analysis
Risk
Sex Factors
Stroke Volume
ventricular systolic
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:Data were analyzed from 40,195 patients with heart failure with reduced ejection fraction enrolled in 12 clinical trials in the 1995–2014 period. Sudden-death rates declined substantially over time, a finding consistent with a cumulative effect of evidence-based medical therapy.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1609758