Fabrication, characterization, and potential applications of re-assembled casein micelles
Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein ty...
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| Vydáno v: | Critical reviews in food science and nutrition Ročník 64; číslo 22; s. 7916 - 7940 |
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| Jazyk: | angličtina |
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Taylor & Francis
28.08.2024
Taylor & Francis Ltd |
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| Abstract | Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein type (α
s
-, β-, and κ-casein) and the extent of their phosphorylation. rCMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of rCMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use rCMs in both food and non-food applications remains to be fully exploited. The advantage of choosing rCMs over nCMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of rCMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of rCMs in food systems and their industrial production as a dairy ingredient. |
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| AbstractList | Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein type (α
s
-, β-, and κ-casein) and the extent of their phosphorylation. rCMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of rCMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use rCMs in both food and non-food applications remains to be fully exploited. The advantage of choosing rCMs over nCMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of rCMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of rCMs in food systems and their industrial production as a dairy ingredient. Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein type (αₛ-, β-, and κ-casein) and the extent of their phosphorylation. rCMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of rCMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use rCMs in both food and non-food applications remains to be fully exploited. The advantage of choosing rCMs over nCMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of rCMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of rCMs in food systems and their industrial production as a dairy ingredient. Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein type (αs-, β-, and κ-casein) and the extent of their phosphorylation. rCMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of rCMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use rCMs in both food and non-food applications remains to be fully exploited. The advantage of choosing rCMs over nCMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of rCMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of rCMs in food systems and their industrial production as a dairy ingredient. Re-assembled casein micelles ( CMs), were formulated in the 1970s as a model system to understand native casein micelles ( CMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of CMs, such as minerals (citrate, phosphate, and calcium), casein type (α -, β-, and κ-casein) and the extent of their phosphorylation. CMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of CMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use CMs in both food and non-food applications remains to be fully exploited. The advantage of choosing CMs over CMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of CMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of CMs in food systems and their industrial production as a dairy ingredient. Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein type (αs-, β-, and κ-casein) and the extent of their phosphorylation. rCMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of rCMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use rCMs in both food and non-food applications remains to be fully exploited. The advantage of choosing rCMs over nCMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of rCMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of rCMs in food systems and their industrial production as a dairy ingredient.Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works allowed an understanding of the critical factors involved in the formation of rCMs, such as minerals (citrate, phosphate, and calcium), casein type (αs-, β-, and κ-casein) and the extent of their phosphorylation. rCMs were also used to understand the effect of treatments such as ethanol, high hydrostatic pressure and heating on the stability and integrity of the micelles. More recently, the applications of rCMs have been investigated, these include their use as a nanocarrier of bioactive molecules and as electrode-bound substrates to monitor chymosin activity by electrochemistry, to cite a few. Moreover, the potential to use rCMs in both food and non-food applications remains to be fully exploited. The advantage of choosing rCMs over nCMs as an encapsulant and a lucrative food ingredient is due to their more efficient preparation and being free from impurities. In this review, we report on the formulation of rCMs, their physico-chemical properties and their behavior under different physico-chemical treatments, along with the applications and challenges of rCMs in food systems and their industrial production as a dairy ingredient. |
| Author | De Leon-Rodriguez, Luis M. Khan, Muhammed Aslam Li, Jiecheng Hemar, Yacine Yang, Zhi |
| Author_xml | – sequence: 1 givenname: Muhammed Aslam surname: Khan fullname: Khan, Muhammed Aslam organization: Institute for Advanced Study, Shenzhen University – sequence: 2 givenname: Yacine surname: Hemar fullname: Hemar, Yacine organization: Institute for Advanced Study, Shenzhen University – sequence: 3 givenname: Jiecheng surname: Li fullname: Li, Jiecheng organization: School of Chemical Sciences, The University of Auckland – sequence: 4 givenname: Zhi surname: Yang fullname: Yang, Zhi organization: School of Food and Advanced Technology, Massey University – sequence: 5 givenname: Luis M. surname: De Leon-Rodriguez fullname: De Leon-Rodriguez, Luis M. organization: School of Chemical Sciences, The University of Auckland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36995267$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s13738_025_03209_9 crossref_primary_10_1016_j_idairyj_2024_105978 crossref_primary_10_37349_eff_2025_101099 crossref_primary_10_1080_10408398_2024_2373386 crossref_primary_10_1111_1541_4337_70191 crossref_primary_10_1016_j_ifset_2024_103582 crossref_primary_10_1016_j_foodhyd_2023_109610 crossref_primary_10_1016_j_idairyj_2024_105939 |
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| Keywords | Casein nanoparticles encapsulation colloidal calcium phosphate re-assembled casein micelles synthetic casein micelles |
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| Snippet | Re-assembled casein micelles (rCMs), were formulated in the 1970s as a model system to understand native casein micelles (nCMs) in milk. These early works... Re-assembled casein micelles ( CMs), were formulated in the 1970s as a model system to understand native casein micelles ( CMs) in milk. These early works... |
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| SubjectTerms | Animals calcium Calcium phosphates Casein Casein nanoparticles Caseins - chemistry Chemical properties Chemical treatment Chymosin citrates colloidal calcium phosphate Electrochemistry encapsulation Ethanol Fabrication Food Food Handling - methods Food industry high pressure treatment Hydrostatic pressure Impurities Industrial production ingredients Micelles Milk Milk - chemistry nanocarriers phosphates Phosphorylation Physicochemical properties Pressure effects re-assembled casein micelles Substrates synthetic casein micelles |
| Title | Fabrication, characterization, and potential applications of re-assembled casein micelles |
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