Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis

There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in peo...

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Veröffentlicht in:	Critical reviews in food science and nutrition Jg. 62; H. 5; S. 1308 - 1316
Hauptverfasser:	Pereira, Marcos, Dantas Damascena, Alialdo, Galvão Azevedo, Laylla Mirella, de Almeida Oliveira, Tarcio, da Mota Santana, Jerusa
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Taylor & Francis 2022 Taylor & Francis Ltd
Schlagworte:	Adult Aged blood serum Calciferol Coronavirus Coronaviruses COVID-19 COVID-19 infection elderly food science Humans Meta-analysis mortality Observational studies pandemic people SARS-CoV-2 Systematic review Viral diseases Vitamin D Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin deficiency Vitamins COVID-19 meta-analysis Coronavirus pandemic vitamin D
ISSN:	1040-8398, 1549-7852, 1549-7852
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Abstract	There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases-Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI = 0.80-1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30-2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41-2.21) and mortality from COVID-19 (OR = 1.82, 95% CI = 1.06-2.58). We observed a positive association between vitamin D deficiency and the severity of the disease.
AbstractList	There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases-Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI = 0.80-1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30-2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41-2.21) and mortality from COVID-19 (OR = 1.82, 95% CI = 1.06-2.58). We observed a positive association between vitamin D deficiency and the severity of the disease.There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases-Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI = 0.80-1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30-2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41-2.21) and mortality from COVID-19 (OR = 1.82, 95% CI = 1.06-2.58). We observed a positive association between vitamin D deficiency and the severity of the disease. There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the association between vitamin D deficiency and COVID-19 severity, via an analysis of the prevalence of vitamin D deficiency and insufficiency in people with the disease. Five online databases—Embase, PubMed, Scopus, Web of Science, ScienceDirect and pre-print Medrevix were searched. The inclusion criteria were observational studies measuring serum vitamin D in adult and elderly subjects with COVID-19. The main outcome was the prevalence of vitamin D deficiency in severe cases of COVID-19. We carried out a meta-analysis with random effect measures. We identified 1542 articles and selected 27. Vitamin D deficiency was not associated with a higher chance of infection by COVID-19 (OR = 1.35; 95% CI = 0.80–1.88), but we identified that severe cases of COVID-19 present 64% (OR = 1.64; 95% CI = 1.30–2.09) more vitamin D deficiency compared with mild cases. A vitamin D concentration insufficiency increased hospitalization (OR = 1.81, 95% CI = 1.41–2.21) and mortality from COVID-19 (OR = 1.82, 95% CI = 1.06–2.58). We observed a positive association between vitamin D deficiency and the severity of the disease.
Author	Pereira, Marcos Galvão Azevedo, Laylla Mirella Dantas Damascena, Alialdo de Almeida Oliveira, Tarcio da Mota Santana, Jerusa
Author_xml	– sequence: 1 givenname: Marcos surname: Pereira fullname: Pereira, Marcos organization: Collective Health Institute, Federal University of Bahia – sequence: 2 givenname: Alialdo surname: Dantas Damascena fullname: Dantas Damascena, Alialdo organization: Center of Biological and Health Sciences, Universidade Federal do Oeste da Bahia – sequence: 3 givenname: Laylla Mirella surname: Galvão Azevedo fullname: Galvão Azevedo, Laylla Mirella organization: Center of Biological and Health Sciences, Universidade Federal do Oeste da Bahia – sequence: 4 givenname: Tarcio surname: de Almeida Oliveira fullname: de Almeida Oliveira, Tarcio organization: Collective Health Institute, Federal University of Bahia – sequence: 5 givenname: Jerusa surname: da Mota Santana fullname: da Mota Santana, Jerusa organization: School of Nutrition, Federal University of Bahia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33146028$$D View this record in MEDLINE/PubMed
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PublicationTitle	Critical reviews in food science and nutrition
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Snippet	There is still limited evidence regarding the influence of vitamin D in people with COVID-19. In this systematic review and meta-analysis, we analyze the...
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SubjectTerms	Adult Aged blood serum Calciferol Coronavirus Coronaviruses COVID-19 COVID-19 infection elderly food science Humans Meta-analysis mortality Observational studies pandemic people SARS-CoV-2 Systematic review Viral diseases Vitamin D Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin deficiency Vitamins
Title	Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis
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