TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Exhausted CD8 + T (T ex ) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared with effector (T eff ) or memory (T mem ) CD8 + T cells. T ex cells are important clinical targets of checkpoint...

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Bibliographic Details
Published in:	Nature (London) Vol. 571; no. 7764; pp. 211 - 218
Main Authors:	Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.07.2019 Nature Publishing Group
Subjects:	13 38 45 631/250/1619/554/1834 631/250/2152/1566 631/250/2152/1566/2493 631/250/2502/2170 631/250/255/2514 64/60 Animals Antigens Calcineurin Calcineurin - metabolism Calcium Signaling Cancer CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Chromatin Cloning Epigenetics Epistasis, Genetic Exhaustion Feedback, Physiological Female Gene expression Gene Expression Regulation - immunology Genotype Homeodomain Proteins - metabolism Humanities and Social Sciences Immune checkpoint Immunologic Memory Immunological memory Immunotherapy Infections Lymphocytes Lymphocytes T Male Memory cells Mice Mice, Inbred BALB C Mice, Inbred C57BL multidisciplinary NF-AT protein NFATC Transcription Factors - metabolism Receptor mechanisms Receptors Science Science (multidisciplinary) T cell receptors Transcription factors Transcription, Genetic Tumor Escape
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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