Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects

Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in...

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Bibliographic Details
Published in:	Psychological medicine Vol. 52; no. 6; pp. 1069 - 1079
Main Authors:	Nenadić, Igor, Meller, Tina, Schmitt, Simon, Stein, Frederike, Brosch, Katharina, Mosebach, Johannes, Ettinger, Ulrich, Grant, Phillip, Meinert, Susanne, Opel, Nils, Lemke, Hannah, Fingas, Stella, Förster, Katharina, Hahn, Tim, Jansen, Andreas, Andlauer, Till F. M., Forstner, Andreas J., Heilmann-Heimbach, Stefanie, Hall, Alisha S. M., Awasthi, Swapnil, Ripke, Stephan, Witt, Stephanie H., Rietschel, Marcella, Müller-Myhsok, Bertram, Nöthen, Markus M., Dannlowski, Udo, Krug, Axel, Streit, Fabian, Kircher, Tilo
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 01.04.2022
Subjects:	Affective disorders Bipolar Disorder Blood & organ donations Blood donors Disorders Donors Emotional disorders Genetic susceptibility Genetics Genomes Genotype & phenotype Hallucinations Humans Liability Mental disorders Multicenter studies Original Article Personality disorders Phenotype Phenotypes Polygenic inheritance Population Psychosis Psychotic Disorders - psychology Quantitative psychology Questionnaires Risk Schizophrenia Schizophrenia - genetics Schizotypal personality Schizotypal personality disorder Schizotypal Personality Disorder - psychology major depressive disorder Bipolar disorder depression schizophrenia schizotypy psychosis proneness psychosis
ISSN:	0033-2917, 1469-8978, 1469-8978
Online Access:	Get full text
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