Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer c...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature cell biology Ročník 20; číslo 8; s. 966 - 978
Hlavní autori:	Er, Ekrem Emrah, Valiente, Manuel, Ganesh, Karuna, Zou, Yilong, Agrawal, Saloni, Hu, Jing, Griscom, Bailey, Rosenblum, Marc, Boire, Adrienne, Brogi, Edi, Giancotti, Filippo G., Schachner, Melitta, Malladi, Srinivas, Massagué, Joan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.08.2018 Nature Publishing Group
Predmet:	13/1 13/105 13/106 13/109 13/31 13/89 13/95 14/1 14/19 14/35 59 59/5 631/67 631/67/322 631/80/79/2066 631/80/86 82 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - secondary Cancer Cancer Research Capillaries Capillaries - metabolism Capillaries - pathology Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cell Biology Cell Communication Cell Movement Cell Proliferation Cell Shape Colonization Developmental Biology Female HCT116 Cells HEK293 Cells Humans ILK protein Infiltration Integrin beta1 - genetics Integrin beta1 - metabolism Invasiveness Kinases Latency Life Sciences Male Mechanotransduction Mechanotransduction, Cellular Metastases Metastasis Mice, Inbred C57BL Mice, Inbred NOD Molecular chains Neural cell adhesion molecule Neural Cell Adhesion Molecule L1 - genetics Neural Cell Adhesion Molecule L1 - metabolism Organs Pericytes Pericytes - metabolism Pericytes - pathology Phosphoproteins - genetics Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Signaling Spreading Stem Cells Time Factors Tissue Culture Techniques Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors Tumor Microenvironment Yes-associated protein
ISSN:	1465-7392, 1476-4679, 1476-4679
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). This spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β 1 integrin and ILK (integrin-linked kinase). L1CAM and YAP signalling enables the outgrowth of metastasis-initiating cells both immediately following their infiltration of target organs and after they exit from a period of latency. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic. Massagué and colleagues show that disseminated cancer cells use L1CAM to spread on capillaries and to achieve their outgrowth through activating YAP signalling.
AbstractList	Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). This spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β1 integrin and ILK (integrin-linked kinase). L1CAM and YAP signalling enables the outgrowth of metastasis-initiating cells both immediately following their infiltration of target organs and after they exit from a period of latency. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic. Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). This spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β integrin and ILK (integrin-linked kinase). L1CAM and YAP signalling enables the outgrowth of metastasis-initiating cells both immediately following their infiltration of target organs and after they exit from a period of latency. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic. Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signaling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ cell adhesion molecule L1 (L1CAM) to spread on capillaries and activate the mechanotransduction effectors Yes-associated protein (YAP) and myocardin-related transcription factor (MRTF). This L1CAM-mediated spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β1 integrin and integrin linked kinase (ILK). L1CAM-YAP signaling enables the outgrowth of metastasis-initiating cells both immediately upon their infiltration of target organs and after they exit from a period of dormancy. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents, and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic. Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). This spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β1 integrin and ILK (integrin-linked kinase). L1CAM and YAP signalling enables the outgrowth of metastasis-initiating cells both immediately following their infiltration of target organs and after they exit from a period of latency. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic.Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). This spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β1 integrin and ILK (integrin-linked kinase). L1CAM and YAP signalling enables the outgrowth of metastasis-initiating cells both immediately following their infiltration of target organs and after they exit from a period of latency. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic. Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). This spreading is robust enough to displace resident pericytes, which also use L1CAM for perivascular spreading. L1CAM activates YAP by engaging β 1 integrin and ILK (integrin-linked kinase). L1CAM and YAP signalling enables the outgrowth of metastasis-initiating cells both immediately following their infiltration of target organs and after they exit from a period of latency. Our results identify an important step in the initiation of metastatic colonization, define its molecular constituents and provide an explanation for the widespread association of L1CAM with metastatic relapse in the clinic. Massagué and colleagues show that disseminated cancer cells use L1CAM to spread on capillaries and to achieve their outgrowth through activating YAP signalling.
Author	Brogi, Edi Schachner, Melitta Ganesh, Karuna Boire, Adrienne Massagué, Joan Valiente, Manuel Rosenblum, Marc Giancotti, Filippo G. Er, Ekrem Emrah Agrawal, Saloni Griscom, Bailey Hu, Jing Zou, Yilong Malladi, Srinivas
AuthorAffiliation	7 Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041, China 1 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 2 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 6 Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience Rutgers University, Piscataway, NJ 08554, USA 8 These authors contributed equally to this work 3 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 4 Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 5 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
AuthorAffiliation_xml	– name: 8 These authors contributed equally to this work – name: 4 Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 6 Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience Rutgers University, Piscataway, NJ 08554, USA – name: 3 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 7 Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041, China – name: 1 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 2 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA – name: 5 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Author_xml	– sequence: 1 givenname: Ekrem Emrah surname: Er fullname: Er, Ekrem Emrah organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center – sequence: 2 givenname: Manuel orcidid: 0000-0002-0647-7542 surname: Valiente fullname: Valiente, Manuel organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Brain Metastasis Group, Spanish National Cancer Research Center (CNIO) – sequence: 3 givenname: Karuna surname: Ganesh fullname: Ganesh, Karuna organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 4 givenname: Yilong surname: Zou fullname: Zou, Yilong organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center – sequence: 5 givenname: Saloni surname: Agrawal fullname: Agrawal, Saloni organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center – sequence: 6 givenname: Jing surname: Hu fullname: Hu, Jing organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center – sequence: 7 givenname: Bailey surname: Griscom fullname: Griscom, Bailey organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center – sequence: 8 givenname: Marc surname: Rosenblum fullname: Rosenblum, Marc organization: Department of Pathology, Memorial Sloan Kettering Cancer Center – sequence: 9 givenname: Adrienne orcidid: 0000-0002-9029-1248 surname: Boire fullname: Boire, Adrienne organization: Department of Neurology, Memorial Sloan Kettering Cancer Center, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center – sequence: 10 givenname: Edi surname: Brogi fullname: Brogi, Edi organization: Department of Pathology, Memorial Sloan Kettering Cancer Center – sequence: 11 givenname: Filippo G. surname: Giancotti fullname: Giancotti, Filippo G. organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Department of Cancer Biology and David E. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center – sequence: 12 givenname: Melitta surname: Schachner fullname: Schachner, Melitta organization: Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Center for Neuroscience, Shantou University Medical College, Shantou – sequence: 13 givenname: Srinivas surname: Malladi fullname: Malladi, Srinivas organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Department of Pathology, The University of Texas Southwestern Medical Center – sequence: 14 givenname: Joan surname: Massagué fullname: Massagué, Joan email: j-massague@ski.mskcc.org organization: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30038252$$D View this record in MEDLINE/PubMed
BookMark	eNp9UU1vFSEUJabGfugPcGNI3LgZhRlgYGPSNK1tUmNj6sIVYeDOkzoDT-A1ef56GV_rRxNdEE7gnJNz7zlEeyEGQOg5Ja8p6eSbzCjnoiFU1tPJRj5CB5T1omGiV3sLFrzpO9Xuo8OcbwihjJH-CdrvSJW3vD1AqytI3m4LNJP_CjivExjnwwoPW-x8zjD7YAo4bE2wkLCFacrY2OJv63PGn4-vsAkOv_94fYbHmPAMxeRiirfYxikG_73iGJ6ix6OZMjy7u4_Qp7PT65Pz5vLDu4uT48vGsrYvjSTMGEms5Io7QSoUllHh2CAUBzrAQHrSwTiqQULv6CitAq4ckZJZKtruCL3d-a43wwzOQijJTHqd_GzSVkfj9d8_wX_Rq3irRd1ZS7pq8OrOIMVvG8hFzz4vU5sAcZN1S3rOmVDdQn35gHoTNynU8RaWUNVN0sp68WeiX1HuO6iEfkewKeacYNTWl59LqwH9pCnRS9t617aubeulbS2rkj5Q3pv_T9PuNLXq2jOk36H_LfoByqi8yw
CitedBy_id	crossref_primary_10_1152_physrev_00046_2024 crossref_primary_10_1016_j_cellsig_2023_110749 crossref_primary_10_1038_s41591_020_01195_4 crossref_primary_10_1158_2159_8290_CD_21_0010 crossref_primary_10_1038_s43018_022_00353_6 crossref_primary_10_1158_2159_8290_CD_19_1228 crossref_primary_10_1038_s41388_023_02731_5 crossref_primary_10_1007_s11427_023_2417_3 crossref_primary_10_1042_BST20240244 crossref_primary_10_1002_bies_202400261 crossref_primary_10_1016_j_cmet_2021_12_001 crossref_primary_10_3389_fonc_2020_594514 crossref_primary_10_1038_s41467_024_52888_0 crossref_primary_10_3390_cancers14133209 crossref_primary_10_1038_s42003_022_04314_8 crossref_primary_10_3390_ijtm4030031 crossref_primary_10_1016_j_neuron_2025_08_003 crossref_primary_10_1038_s41568_019_0180_2 crossref_primary_10_3390_cells9010250 crossref_primary_10_15252_emmm_202114552 crossref_primary_10_1038_s41568_025_00848_1 crossref_primary_10_1016_j_ccell_2019_08_006 crossref_primary_10_1111_cas_70050 crossref_primary_10_1016_j_jconrel_2024_09_003 crossref_primary_10_1016_j_jare_2025_05_028 crossref_primary_10_1038_s41388_025_03461_6 crossref_primary_10_1007_s10456_019_09695_9 crossref_primary_10_1038_s41598_019_53659_4 crossref_primary_10_3390_cancers15194701 crossref_primary_10_1242_dmm_052449 crossref_primary_10_1016_j_isci_2024_111690 crossref_primary_10_3390_ijms22041886 crossref_primary_10_1016_j_semcancer_2022_11_003 crossref_primary_10_3390_cancers16040694 crossref_primary_10_1002_adbi_202000012 crossref_primary_10_1016_j_ccell_2023_12_018 crossref_primary_10_1007_s10555_021_10000_8 crossref_primary_10_1016_j_devcel_2024_01_010 crossref_primary_10_1097_CM9_0000000000002127 crossref_primary_10_1038_s41571_019_0181_9 crossref_primary_10_1136_gutjnl_2019_319748 crossref_primary_10_3389_fimmu_2019_01836 crossref_primary_10_1073_pnas_2007991117 crossref_primary_10_1038_s41374_022_00803_w crossref_primary_10_1080_01616412_2021_1934311 crossref_primary_10_3892_ijo_2024_5642 crossref_primary_10_1158_0008_5472_CAN_20_3558 crossref_primary_10_1016_j_bbcan_2019_06_002 crossref_primary_10_1063_5_0194539 crossref_primary_10_1126_scitranslmed_abo1050 crossref_primary_10_1016_j_ajpath_2020_04_007 crossref_primary_10_1016_j_ccell_2019_01_007 crossref_primary_10_1016_j_devcel_2021_09_007 crossref_primary_10_1186_s12885_019_6091_5 crossref_primary_10_1038_s43018_021_00297_3 crossref_primary_10_3389_fonc_2024_1359069 crossref_primary_10_1002_ctm2_1433 crossref_primary_10_3389_fonc_2022_965277 crossref_primary_10_1038_s41388_021_02174_w crossref_primary_10_1080_0284186X_2019_1667022 crossref_primary_10_1038_s41576_022_00493_6 crossref_primary_10_1007_s10456_019_09693_x crossref_primary_10_1016_j_stem_2018_12_009 crossref_primary_10_1038_s41467_020_16832_2 crossref_primary_10_1016_j_it_2021_12_003 crossref_primary_10_1038_s41416_021_01686_2 crossref_primary_10_1038_s43018_023_00595_y crossref_primary_10_1016_j_brainresbull_2020_06_004 crossref_primary_10_1016_j_celrep_2024_113989 crossref_primary_10_1186_s40364_024_00577_x crossref_primary_10_3390_cancers15082258 crossref_primary_10_1038_s43018_024_00780_7 crossref_primary_10_1016_j_bbcan_2022_188756 crossref_primary_10_3390_cancers15113021 crossref_primary_10_1007_s00018_023_04934_1 crossref_primary_10_1007_s10555_023_10094_2 crossref_primary_10_1038_s41568_023_00568_4 crossref_primary_10_1007_s13402_025_01073_6 crossref_primary_10_1016_j_bbrc_2018_10_037 crossref_primary_10_1016_j_semcancer_2020_09_001 crossref_primary_10_1177_03000605221140683 crossref_primary_10_3389_fimmu_2023_1276602 crossref_primary_10_3390_cancers13030525 crossref_primary_10_1002_mco2_70119 crossref_primary_10_3390_jcm11102852 crossref_primary_10_1242_jcs_262066 crossref_primary_10_3390_ijms25010315 crossref_primary_10_1038_s41388_020_01530_6 crossref_primary_10_1007_s10456_023_09876_7 crossref_primary_10_1186_s12943_023_01737_7 crossref_primary_10_3389_fcell_2023_1221784 crossref_primary_10_3390_biom12030439 crossref_primary_10_1038_s41556_024_01409_8 crossref_primary_10_3390_ijms26052307 crossref_primary_10_1161_CIRCRESAHA_122_322113 crossref_primary_10_1016_j_devcel_2019_04_015 crossref_primary_10_1093_neuonc_noab159 crossref_primary_10_3390_cancers15235497 crossref_primary_10_1038_s41467_025_60141_5 crossref_primary_10_1038_s41565_023_01535_8 crossref_primary_10_1016_j_clinsp_2022_100040 crossref_primary_10_1016_j_pan_2020_12_003 crossref_primary_10_1038_s41568_019_0168_y crossref_primary_10_1016_j_drup_2024_101096 crossref_primary_10_1016_j_immuni_2021_02_020 crossref_primary_10_1002_ijc_33247 crossref_primary_10_1016_j_stem_2019_11_015 crossref_primary_10_1038_s41419_022_05244_3 crossref_primary_10_1016_j_bbcan_2024_189181 crossref_primary_10_1016_j_devcel_2019_03_026 crossref_primary_10_1158_0008_5472_CAN_22_0419 crossref_primary_10_3390_cells11193085 crossref_primary_10_1016_j_bbrc_2024_150431 crossref_primary_10_1016_j_semcdb_2019_12_005 crossref_primary_10_3389_fphar_2024_1426033 crossref_primary_10_1038_s41416_023_02530_5 crossref_primary_10_3389_fbioe_2020_608526 crossref_primary_10_1038_s43018_022_00473_z crossref_primary_10_1063_1_5083143 crossref_primary_10_1016_j_stem_2024_04_004 crossref_primary_10_3389_fonc_2023_1191980 crossref_primary_10_1038_s42003_025_08440_x crossref_primary_10_1186_s13058_023_01728_y crossref_primary_10_1016_j_pharmthera_2019_03_007 crossref_primary_10_1038_s41416_020_01127_6 crossref_primary_10_1038_s43018_024_00854_6 crossref_primary_10_1186_s43556_025_00251_0 crossref_primary_10_1126_scitranslmed_adg3840 crossref_primary_10_1038_s43018_019_0006_x crossref_primary_10_1038_s41556_018_0162_8 crossref_primary_10_1038_s41588_023_01526_4 crossref_primary_10_3390_jcm8050747 crossref_primary_10_1038_s44341_024_00007_x crossref_primary_10_3390_ijms25094811 crossref_primary_10_1016_j_ccell_2023_07_012 crossref_primary_10_1007_s11538_024_01286_0 crossref_primary_10_1158_0008_5472_CAN_21_0933 crossref_primary_10_1016_j_jconrel_2024_12_066 crossref_primary_10_1016_j_jconrel_2024_03_047 crossref_primary_10_1038_s41591_019_0750_6 crossref_primary_10_1186_s43556_020_00022_z crossref_primary_10_1007_s10456_019_09684_y crossref_primary_10_1038_s41568_022_00486_x crossref_primary_10_1055_s_0043_1776996 crossref_primary_10_1038_s43018_019_0014_x crossref_primary_10_3389_fcell_2022_1031262 crossref_primary_10_1038_s43018_023_00525_y crossref_primary_10_1186_s13045_023_01518_1 crossref_primary_10_1186_s12967_025_06559_3 crossref_primary_10_1016_j_canlet_2023_216074 crossref_primary_10_1002_smll_202300403 crossref_primary_10_1016_j_immuni_2021_04_017 crossref_primary_10_1007_s10456_019_09690_0 crossref_primary_10_3389_fonc_2022_977618 crossref_primary_10_1073_pnas_2121779119 crossref_primary_10_1038_s41420_023_01410_4 crossref_primary_10_1242_jcs_218222 crossref_primary_10_1038_s41575_025_01113_4 crossref_primary_10_1038_s41556_024_01532_6 crossref_primary_10_3389_fonc_2019_00219 crossref_primary_10_1038_s41577_025_01173_2 crossref_primary_10_1007_s10456_019_09691_z crossref_primary_10_1038_s41416_022_01795_6 crossref_primary_10_1038_s43018_020_00150_z crossref_primary_10_1038_s43018_020_0088_5 crossref_primary_10_4236_jbm_2025_139018 crossref_primary_10_1007_s10456_019_09698_6 crossref_primary_10_1016_j_ccell_2023_02_016 crossref_primary_10_1016_j_ydbio_2025_06_007 crossref_primary_10_1038_s41577_023_00836_2 crossref_primary_10_1093_neuonc_noae195 crossref_primary_10_1096_fba_2021_00113 crossref_primary_10_3390_cancers13051000 crossref_primary_10_1038_s41416_022_01859_7 crossref_primary_10_1016_j_semcancer_2021_05_007 crossref_primary_10_1038_s41591_022_01749_8 crossref_primary_10_1007_s11033_023_08910_7 crossref_primary_10_1016_j_ccell_2024_08_015 crossref_primary_10_1073_pnas_2111046118
Cites_doi	10.1523/JNEUROSCI.23-32-10419.2003 10.1016/j.devcel.2011.07.001 10.1016/j.cell.2013.07.042 10.1007/s12307-012-0128-5 10.1073/pnas.1212021109 10.1172/JCI66549 10.1016/j.cell.2013.02.021 10.1186/s13059-014-0550-8 10.1038/nature17040 10.1016/j.cell.2013.07.036 10.1016/j.cell.2014.01.040 10.1038/nature10137 10.1038/sj.bjc.6601727 10.1038/nrm2890 10.1038/ncomms3976 10.1016/S0140-6736(00)02268-6 10.1083/jcb.117.2.461 10.1038/nm.2072 10.1073/pnas.0506580102 10.1016/j.cell.2009.04.030 10.1038/nature17038 10.1016/j.cell.2016.02.025 10.1073/pnas.0904227106 10.1523/JNEUROSCI.22-12-04918.2002 10.1038/291334a0 10.1016/j.cell.2008.10.029 10.1038/nature25739 10.1080/00313020412331282708 10.1016/j.trecan.2015.07.009 10.1038/ncb2884 10.1038/nature12984 10.1038/nprot.2014.085 10.1016/S1535-6108(03)00132-6 10.1016/j.cell.2017.10.008 10.4161/cam.20832 10.1002/ijc.29658 10.1002/eji.1830261035 10.1242/jcs.056770 10.1126/scitranslmed.3004394 10.1126/science.284.5422.1994 10.1111/j.1365-2559.2007.02800.x 10.1038/jid.1989.10 10.1038/nrc3793 10.1038/nature08021 10.1038/nature03799 10.1002/cam4.105 10.1038/ncb2767 10.1080/21659087.2015.1086613 10.1016/S0008-6363(96)00113-7 10.1038/nm.3029 10.1016/j.chembiol.2010.07.009 10.1016/j.cell.2008.10.028 10.1016/j.celrep.2013.11.020 10.1038/ng1197-346 10.1038/ncb1833 10.1101/gad.535409 10.1242/dev.047951 10.1172/JCI67250 10.1101/gad.1664408 10.1016/j.cell.2016.11.005 10.1101/gad.1909210 10.1158/0008-5472.CAN-08-3051 10.1016/j.cell.2016.11.037 10.1016/j.ccr.2013.08.012 10.1038/nature09881 10.1161/CIRCRESAHA.107.167908 10.1242/dev.126.14.3047
ContentType	Journal Article
Copyright	The Author(s) 2018 Copyright Nature Publishing Group Aug 2018
Copyright_xml	– notice: The Author(s) 2018 – notice: Copyright Nature Publishing Group Aug 2018
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI RC3 7X8 5PM
DOI	10.1038/s41556-018-0138-8
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest Central Student MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1476-4679
EndPage	978
ExternalDocumentID	PMC6467203 30038252 10_1038_s41556_018_0138_8
Genre	Video-Audio Media Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: R25 CA020449 – fundername: NCI NIH HHS grantid: R01 CA191222 – fundername: NCI NIH HHS grantid: T32 CA009207 – fundername: NCI NIH HHS grantid: P01 CA094060 – fundername: NCI NIH HHS grantid: K08 CA230213 – fundername: NCI NIH HHS grantid: P01 CA129243 – fundername: NCI NIH HHS grantid: P30 CA008748
GroupedDBID	--- .55 .GJ 0R~ 123 29M 36B 39C 3V. 4.4 53G 5BI 5RE 70F 7X7 88A 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AAEEF AARCD AAYZH AAZLF ABAWZ ABCQX ABDBF ABEFU ABJNI ABLJU ABNNU ABUWG ACBWK ACGFS ACIWK ACNCT ACPRK ACRPL ACUHS ADBBV ADNMO ADQMX AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AFWHJ AGAYW AGGDT AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 D0L DB5 DU5 EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR ISR ITC J5H L-9 L7B LK8 M0L M1P M7P N9A NNMJJ O9- ODYON P2P PQQKQ PROAC PSQYO Q2X QF4 QM4 QN7 QO4 RNS RNT RNTTT SHXYY SIXXV SKT SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP X7M Y6R ZGI ~02 ~8M AAYXX AFANA AFFHD AGSTI ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NFIDA NPM 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PQEST PQUKI RC3 7X8 5PM
ID	FETCH-LOGICAL-c427t-804aa80c8595d60a806c416d4b695e1beb0703eff9b8e7d1f8c9e59d0884c1623
IEDL.DBID	M7P
ISICitedReferencesCount	209
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000440057000015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1465-7392 1476-4679
IngestDate	Tue Nov 04 02:01:09 EST 2025 Sun Nov 09 12:26:32 EST 2025 Tue Oct 07 05:11:42 EDT 2025 Thu Apr 03 07:01:47 EDT 2025 Sat Nov 29 01:36:17 EST 2025 Tue Nov 18 22:28:01 EST 2025 Fri Feb 21 02:40:05 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	8
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c427t-804aa80c8595d60a806c416d4b695e1beb0703eff9b8e7d1f8c9e59d0884c1623
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 AUTHOR CONTRIBUTIONS Current address: Brain Metastasis Group, Spanish National Cancer Research Center (CNIO), Madrid E28029, Spain (M.V); Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA (F.G); Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA (S.M.) E.E.E., M.V. and J.M. conceptualized the project. E.E.E., M.V., K.G. and S.M. designed and performed the experiments. Y.Z. performed bioinformatics analyses. S.A. and B.G. assisted with the experiments. F.G. contributed to experimental design. M.S. provided the L1cam flox mice. E.B., A.B. and M.R. provided clinical samples and interpretation. E.E.E., K.G., M.V.C and J.M. wrote the manuscript.
ORCID	0000-0002-9029-1248 0000-0002-0647-7542
PMID	30038252
PQID	2076903381
PQPubID	45779
PageCount	13
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_6467203 proquest_miscellaneous_2075546933 proquest_journals_2076903381 pubmed_primary_30038252 crossref_citationtrail_10_1038_s41556_018_0138_8 crossref_primary_10_1038_s41556_018_0138_8 springer_journals_10_1038_s41556_018_0138_8
PublicationCentury	2000
PublicationDate	2018-08-01
PublicationDateYYYYMMDD	2018-08-01
PublicationDate_xml	– month: 08 year: 2018 text: 2018-08-01 day: 01
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature cell biology
PublicationTitleAbbrev	Nat Cell Biol
PublicationTitleAlternate	Nat Cell Biol
PublicationYear	2018
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Ghajar (CR11) 2013; 15 Dahme (CR16) 1997; 17 Polleux, Ghosh (CR63) 2002; 2002 Thelen (CR45) 2002; 22 Byron (CR46) 2009; 122 Vanlandewijck (CR24) 2018; 554 Sardari Nia, Hendriks, Friedel, Van Schil, Van Marck (CR53) 2007; 51 Law (CR39) 2003; 23 Lawley, Kubota (CR62) 1989; 93 Iwamoto, Bjorklund, Lundberg, Kirik, Wandless (CR31) 2010; 17 Barnhill, Lugassy (CR50) 2004; 36 Lugassy (CR51) 2013; 6 Donnem (CR12) 2013; 2 Armulik, Genove, Betsholtz (CR18) 2011; 21 Zhu (CR40) 2011; 138 Altevogt, Doberstein, Fogel (CR14) 2016; 138 Lambert, Pattabiraman, Weinberg (CR3) 2017; 168 Entenberg (CR6) 2015; 4 McCuskey, Urbaschek, Urbaschek (CR37) 1996; 32 Ferreira, Fujiwara, Morita, Watt (CR47) 2009; 69 Doyle (CR65) 2008; 135 Valiente (CR13) 2014; 156 Rafii, Butler, Ding (CR9) 2016; 529 Massague, Obenauf (CR1) 2016; 529 Fellmann (CR71) 2013; 5 Zhao, Li, Lei, Guan (CR33) 2010; 24 Ziegler (CR38) 2013; 123 Shibue, Brooks, Weinberg (CR23) 2013; 24 Pezzella (CR48) 1997; 151 Zhang (CR66) 2013; 154 Elosegui-Artola (CR35) 2017; 171 Ritsma (CR7) 2012; 4 Winslow (CR25) 2011; 473 Mohseni (CR69) 2014; 16 Aragona (CR34) 2013; 154 Sosa, Bragado, Aguirre-Ghiso (CR2) 2014; 14 Stessels (CR54) 2004; 90 Moroishi (CR57) 2016; 167 Lamar (CR29) 2012; 109 Kang (CR58) 2003; 3 Minn (CR21) 2005; 436 Shibue, Weinberg (CR22) 2009; 106 Kogata, Tribe, Fassler, Way, Adams (CR42) 2009; 23 Morrison, Scadden (CR8) 2014; 505 Hopewell (CR68) 2013; 123 Heiman (CR64) 2008; 135 Dupont (CR32) 2011; 474 Nguyen (CR19) 2009; 138 Cheng (CR55) 2013; 153 Olson, Nordheim (CR28) 2010; 11 Euer (CR36) 2005; 13 (CR52) 2000; 355 Holash (CR49) 1999; 284 Love, Huber, Anders (CR67) 2014; 15 Abraham, Kogata, Fassler, Adams (CR43) 2008; 102 Medjkane, Perez-Sanchez, Gaggioli, Sahai, Treisman (CR30) 2009; 11 Serrano, McDonald, Lock, Muller, Dedhar (CR44) 2013; 4 Kasai (CR60) 1981; 291 Kiefel (CR17) 2012; 6 Hellstrom, Kalen, Lindahl, Abramsson, Betsholtz (CR56) 1999; 126 Heiman, Kulicke, Fenster, Greengard, Heintz (CR26) 2014; 9 Vanharanta (CR59) 2013; 19 Zhao (CR27) 2008; 22 Passaniti (CR41) 1992; 67 Bos (CR20) 2009; 459 van de Wiel-van Kemenade (CR61) 1992; 117 Obenauf, Massague (CR4) 2015; 1 Kienast (CR5) 2010; 16 Subramanian (CR70) 2005; 102 Malladi (CR10) 2016; 165 Ebeling (CR15) 1996; 26 A Subramanian (138_CR70) 2005; 102 M Mohseni (138_CR69) 2014; 16 A Elosegui-Artola (138_CR35) 2017; 171 K Thelen (138_CR45) 2002; 22 TJ Lawley (138_CR62) 1989; 93 L Ritsma (138_CR7) 2012; 4 P Sardari Nia (138_CR53) 2007; 51 M Heiman (138_CR26) 2014; 9 J Holash (138_CR49) 1999; 284 RL Barnhill (138_CR50) 2004; 36 E Wiel-van Kemenade van de (138_CR61) 1992; 117 D Entenberg (138_CR6) 2015; 4 O Ebeling (138_CR15) 1996; 26 M Kasai (138_CR60) 1981; 291 M Ferreira (138_CR47) 2009; 69 I Serrano (138_CR44) 2013; 4 J Massague (138_CR1) 2016; 529 AJ Minn (138_CR21) 2005; 436 Y Kienast (138_CR5) 2010; 16 C Lugassy (138_CR51) 2013; 6 EL Hopewell (138_CR68) 2013; 123 S Malladi (138_CR10) 2016; 165 M Valiente (138_CR13) 2014; 156 F Stessels (138_CR54) 2004; 90 CM Ghajar (138_CR11) 2013; 15 M Vanlandewijck (138_CR24) 2018; 554 M Dahme (138_CR16) 1997; 17 MM Winslow (138_CR25) 2011; 473 T Donnem (138_CR12) 2013; 2 DX Nguyen (138_CR19) 2009; 138 F Polleux (138_CR63) 2002; 2002 JP Doyle (138_CR65) 2008; 135 A Byron (138_CR46) 2009; 122 SJ Morrison (138_CR8) 2014; 505 M Iwamoto (138_CR31) 2010; 17 M Aragona (138_CR34) 2013; 154 N Kogata (138_CR42) 2009; 23 RS McCuskey (138_CR37) 1996; 32 S Rafii (138_CR9) 2016; 529 C Fellmann (138_CR71) 2013; 5 T Shibue (138_CR22) 2009; 106 F Pezzella (138_CR48) 1997; 151 S Medjkane (138_CR30) 2009; 11 S Dupont (138_CR32) 2011; 474 B Zhao (138_CR33) 2010; 24 Y Kang (138_CR58) 2003; 3 JW Law (138_CR39) 2003; 23 NI Euer (138_CR36) 2005; 13 MI Love (138_CR67) 2014; 15 A Passaniti (138_CR41) 1992; 67 X Zhu (138_CR40) 2011; 138 JM Lamar (138_CR29) 2012; 109 A Armulik (138_CR18) 2011; 21 EN Olson (138_CR28) 2010; 11 T Ziegler (138_CR38) 2013; 123 M Heiman (138_CR64) 2008; 135 L Cheng (138_CR55) 2013; 153 B Zhao (138_CR27) 2008; 22 AC Obenauf (138_CR4) 2015; 1 H Kiefel (138_CR17) 2012; 6 XH Zhang (138_CR66) 2013; 154 AW Lambert (138_CR3) 2017; 168 PD Bos (138_CR20) 2009; 459 P Altevogt (138_CR14) 2016; 138 S Abraham (138_CR43) 2008; 102 T Shibue (138_CR23) 2013; 24 T Moroishi (138_CR57) 2016; 167 S Vanharanta (138_CR59) 2013; 19 M Hellstrom (138_CR56) 1999; 126 MS Sosa (138_CR2) 2014; 14 Breast Cancer Progression Working Party. (138_CR52) 2000; 355 30038255 - Nat Cell Biol. 2018 Aug;20(8):860-862 30542103 - Nat Cell Biol. 2019 Mar;21(3):408
References_xml	– volume: 23 start-page: 10419 year: 2003 end-page: 10432 ident: CR39 article-title: Decreased anxiety, altered place learning, and increased CA1 basal excitatory synaptic transmission in mice with conditional ablation of the neural cell adhesion molecule L1 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-32-10419.2003 – volume: 21 start-page: 193 year: 2011 end-page: 215 ident: CR18 article-title: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises publication-title: Dev. Cell doi: 10.1016/j.devcel.2011.07.001 – volume: 154 start-page: 1047 year: 2013 end-page: 1059 ident: CR34 article-title: A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors publication-title: Cell doi: 10.1016/j.cell.2013.07.042 – volume: 6 start-page: 19 year: 2013 end-page: 29 ident: CR51 article-title: Pilot study on ‘‘pericytic mimicry’’ and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface publication-title: Cancer Microenviron. doi: 10.1007/s12307-012-0128-5 – volume: 109 start-page: E2441 year: 2012 end-page: 2450 ident: CR29 article-title: The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1212021109 – volume: 123 start-page: 3436 year: 2013 end-page: 3445 ident: CR38 article-title: Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. publication-title: J. Clin. Invest. doi: 10.1172/JCI66549 – volume: 153 start-page: 139 year: 2013 end-page: 152 ident: CR55 article-title: Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth publication-title: Cell doi: 10.1016/j.cell.2013.02.021 – volume: 15 year: 2014 ident: CR67 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 529 start-page: 316 year: 2016 end-page: 325 ident: CR9 article-title: Angiocrine functions of organ-specific endothelial cells publication-title: Nature doi: 10.1038/nature17040 – volume: 154 start-page: 1060 year: 2013 end-page: 1073 ident: CR66 article-title: Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma publication-title: Cell doi: 10.1016/j.cell.2013.07.036 – volume: 156 start-page: 1002 year: 2014 end-page: 1016 ident: CR13 article-title: Serpins promote cancer cell survival and vascular co-option in brain metastasis publication-title: Cell doi: 10.1016/j.cell.2014.01.040 – volume: 474 start-page: 179 year: 2011 end-page: 183 ident: CR32 article-title: Role of YAP/TAZ in mechanotransduction publication-title: Nature doi: 10.1038/nature10137 – volume: 90 start-page: 1429 year: 2004 end-page: 1436 ident: CR54 article-title: Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6601727 – volume: 11 start-page: 353 year: 2010 end-page: 365 ident: CR28 article-title: Linking actin dynamics and gene transcription to drive cellular motile functions publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2890 – volume: 4 year: 2013 ident: CR44 article-title: Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase publication-title: Nat. Commun. doi: 10.1038/ncomms3976 – volume: 355 start-page: 1787 year: 2000 end-page: 1788 ident: CR52 article-title: Evidence for novel non-angiogenic pathway in breast-cancer metastasis publication-title: Lancet doi: 10.1016/S0140-6736(00)02268-6 – volume: 117 start-page: 461 year: 1992 end-page: 470 ident: CR61 article-title: Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the beta subunit of VLA publication-title: J. Cell Biol. doi: 10.1083/jcb.117.2.461 – volume: 16 start-page: 116 year: 2010 end-page: 122 ident: CR5 article-title: Real-time imaging reveals the single steps of brain metastasis formation publication-title: Nat. Med. doi: 10.1038/nm.2072 – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: CR70 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0506580102 – volume: 138 start-page: 51 year: 2009 end-page: 62 ident: CR19 article-title: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis publication-title: Cell doi: 10.1016/j.cell.2009.04.030 – volume: 126 start-page: 3047 year: 1999 end-page: 3055 ident: CR56 article-title: Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse publication-title: Development – volume: 529 start-page: 298 year: 2016 end-page: 306 ident: CR1 article-title: Metastatic colonization by circulating tumour cells publication-title: Nature doi: 10.1038/nature17038 – volume: 165 start-page: 45 year: 2016 end-page: 60 ident: CR10 article-title: Metastatic latency and immune evasion through autocrine inhibition of WNT publication-title: Cell doi: 10.1016/j.cell.2016.02.025 – volume: 106 start-page: 10290 year: 2009 end-page: 10295 ident: CR22 article-title: Integrin β1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0904227106 – volume: 2002 start-page: pl9 year: 2002 ident: CR63 article-title: The slice overlay assay: a versatile tool to study the influence of extracellular signals on neuronal development publication-title: Science’s STKE: Signal Transduct. Knowl. Environ. – volume: 22 start-page: 4918 year: 2002 end-page: 4931 ident: CR45 article-title: The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-12-04918.2002 – volume: 291 start-page: 334 year: 1981 end-page: 335 ident: CR60 article-title: In vivo effect of anti-asialo GM1 antibody on natural killer activity publication-title: Nature doi: 10.1038/291334a0 – volume: 135 start-page: 749 year: 2008 end-page: 762 ident: CR65 article-title: Application of a translational profiling approach for the comparative analysis of CNS cell types publication-title: Cell doi: 10.1016/j.cell.2008.10.029 – volume: 554 start-page: 475 year: 2018 end-page: 480 ident: CR24 article-title: A molecular atlas of cell types and zonation in the brain vasculature publication-title: Nature doi: 10.1038/nature25739 – volume: 13 start-page: 375 year: 2005 end-page: 387 ident: CR36 article-title: Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens publication-title: Oncol. Rep. – volume: 36 start-page: 485 year: 2004 end-page: 490 ident: CR50 article-title: Angiotropic malignant melanoma and extravascular migratory metastasis: description of 36 cases with emphasis on a new mechanism of tumour spread publication-title: Pathology doi: 10.1080/00313020412331282708 – volume: 1 start-page: 76 year: 2015 end-page: 91 ident: CR4 article-title: Surviving at a distance: organ specific metastasis publication-title: Trends Cancer doi: 10.1016/j.trecan.2015.07.009 – volume: 16 start-page: 108 year: 2014 end-page: 117 ident: CR69 article-title: A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway publication-title: Nat. Cell Biol. doi: 10.1038/ncb2884 – volume: 505 start-page: 327 year: 2014 end-page: 334 ident: CR8 article-title: The bone marrow niche for haematopoietic stem cells publication-title: Nature doi: 10.1038/nature12984 – volume: 9 start-page: 1282 year: 2014 end-page: 1291 ident: CR26 article-title: Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP) publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.085 – volume: 3 start-page: 537 year: 2003 end-page: 549 ident: CR58 article-title: A multigenic program mediating breast cancer metastasis to bone publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00132-6 – volume: 171 start-page: 1397 year: 2017 end-page: 1410 ident: CR35 article-title: Force triggers YAP nuclear entry by regulating transport across nuclear pores publication-title: Cell doi: 10.1016/j.cell.2017.10.008 – volume: 6 start-page: 374 year: 2012 end-page: 384 ident: CR17 article-title: L1CAM: a major driver for tumor cell invasion and motility publication-title: Cell Adhes. Migr. doi: 10.4161/cam.20832 – volume: 138 start-page: 1565 year: 2016 end-page: 1576 ident: CR14 article-title: L1CAM in human cancer publication-title: Int. J. Cancer doi: 10.1002/ijc.29658 – volume: 26 start-page: 2508 year: 1996 end-page: 2516 ident: CR15 article-title: L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to α β integrin publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830261035 – volume: 122 start-page: 4009 year: 2009 end-page: 4011 ident: CR46 article-title: Anti-integrin monoclonal antibodies publication-title: J. Cell Sci. doi: 10.1242/jcs.056770 – volume: 151 start-page: 1417 year: 1997 end-page: 1423 ident: CR48 article-title: Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis publication-title: Am. J. Pathol. – volume: 4 start-page: 158ra145 year: 2012 ident: CR7 article-title: Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004394 – volume: 284 start-page: 1994 year: 1999 end-page: 1998 ident: CR49 article-title: Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF publication-title: Science doi: 10.1126/science.284.5422.1994 – volume: 51 start-page: 354 year: 2007 end-page: 361 ident: CR53 article-title: Distinct angiogenic and non-angiogenic growth patterns of lung metastases from renal cell carcinoma publication-title: Histopathology doi: 10.1111/j.1365-2559.2007.02800.x – volume: 93 start-page: 59S year: 1989 end-page: 61S ident: CR62 article-title: Induction of morphologic differentiation of endothelial cells in culture publication-title: J. Invest. Dermatol. doi: 10.1038/jid.1989.10 – volume: 14 start-page: 611 year: 2014 end-page: 622 ident: CR2 article-title: Mechanisms of disseminated cancer cell dormancy: an awakening field publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3793 – volume: 459 start-page: 1005 year: 2009 end-page: 1009 ident: CR20 article-title: Genes that mediate breast cancer metastasis to the brain publication-title: Nature doi: 10.1038/nature08021 – volume: 436 start-page: 518 year: 2005 end-page: 524 ident: CR21 article-title: Genes that mediate breast cancer metastasis to lung publication-title: Nature doi: 10.1038/nature03799 – volume: 2 start-page: 427 year: 2013 end-page: 436 ident: CR12 article-title: Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment? publication-title: Cancer Med. doi: 10.1002/cam4.105 – volume: 15 start-page: 807 year: 2013 end-page: 817 ident: CR11 article-title: The perivascular niche regulates breast tumour dormancy publication-title: Nat. Cell Biol. doi: 10.1038/ncb2767 – volume: 4 start-page: e1086613 year: 2015 ident: CR6 article-title: In vivo subcellular resolution optical imaging in the lung reveals early metastatic proliferation and motility. publication-title: Intravital doi: 10.1080/21659087.2015.1086613 – volume: 32 start-page: 752 year: 1996 end-page: 763 ident: CR37 article-title: The microcirculation during endotoxemia publication-title: Cardiovasc. Res. doi: 10.1016/S0008-6363(96)00113-7 – volume: 19 start-page: 50 year: 2013 end-page: 56 ident: CR59 article-title: Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer publication-title: Nat. Med. doi: 10.1038/nm.3029 – volume: 17 start-page: 981 year: 2010 end-page: 988 ident: CR31 article-title: A general chemical method to regulate protein stability in the mammalian central nervous system publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2010.07.009 – volume: 135 start-page: 738 year: 2008 end-page: 748 ident: CR64 article-title: A translational profiling approach for the molecular characterization of CNS cell types publication-title: Cell doi: 10.1016/j.cell.2008.10.028 – volume: 5 start-page: 1704 year: 2013 end-page: 1713 ident: CR71 article-title: An optimized microRNA backbone for effective single-copy RNAi publication-title: Cell Rep. doi: 10.1016/j.celrep.2013.11.020 – volume: 17 start-page: 346 year: 1997 end-page: 349 ident: CR16 article-title: Disruption of the mouse L1 gene leads to malformations of the nervous system publication-title: Nat. Genet. doi: 10.1038/ng1197-346 – volume: 11 start-page: 257 year: 2009 end-page: 268 ident: CR30 article-title: Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis publication-title: Nat. Cell Biol. doi: 10.1038/ncb1833 – volume: 23 start-page: 2278 year: 2009 end-page: 2283 ident: CR42 article-title: Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction publication-title: Genes Dev. doi: 10.1101/gad.535409 – volume: 138 start-page: 745 year: 2011 end-page: 753 ident: CR40 article-title: Age-dependent fate and lineage restriction of single NG2 cells publication-title: Development doi: 10.1242/dev.047951 – volume: 123 start-page: 2509 year: 2013 end-page: 2522 ident: CR68 article-title: Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance publication-title: J. Clin. Invest. doi: 10.1172/JCI67250 – volume: 22 start-page: 1962 year: 2008 end-page: 1971 ident: CR27 article-title: TEAD mediates YAP-dependent gene induction and growth control publication-title: Genes Dev. doi: 10.1101/gad.1664408 – volume: 167 start-page: 1525 year: 2016 end-page: 1539 e1517 ident: CR57 article-title: The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity publication-title: Cell doi: 10.1016/j.cell.2016.11.005 – volume: 24 start-page: 862 year: 2010 end-page: 874 ident: CR33 article-title: The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version publication-title: Genes Dev. doi: 10.1101/gad.1909210 – volume: 69 start-page: 1334 year: 2009 end-page: 1342 ident: CR47 article-title: An activating β1 integrin mutation increases the conversion of benign to malignant skin tumors publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-3051 – volume: 168 start-page: 670 year: 2017 end-page: 691 ident: CR3 article-title: Emerging biological principles of metastasis publication-title: Cell doi: 10.1016/j.cell.2016.11.037 – volume: 24 start-page: 481 year: 2013 end-page: 498 ident: CR23 article-title: An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.08.012 – volume: 473 start-page: 101 year: 2011 end-page: 104 ident: CR25 article-title: Suppression of lung adenocarcinoma progression by Nkx2-1 publication-title: Nature doi: 10.1038/nature09881 – volume: 67 start-page: 519 year: 1992 end-page: 528 ident: CR41 article-title: A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor publication-title: Lab. Invest. – volume: 102 start-page: 562 year: 2008 end-page: 570 ident: CR43 article-title: Integrin β1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.107.167908 – volume: 123 start-page: 3436 year: 2013 ident: 138_CR38 publication-title: J. Clin. Invest. doi: 10.1172/JCI66549 – volume: 102 start-page: 15545 year: 2005 ident: 138_CR70 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0506580102 – volume: 93 start-page: 59S year: 1989 ident: 138_CR62 publication-title: J. Invest. Dermatol. doi: 10.1038/jid.1989.10 – volume: 32 start-page: 752 year: 1996 ident: 138_CR37 publication-title: Cardiovasc. Res. doi: 10.1016/S0008-6363(96)00113-7 – volume: 4 start-page: 158ra145 year: 2012 ident: 138_CR7 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004394 – volume: 138 start-page: 745 year: 2011 ident: 138_CR40 publication-title: Development doi: 10.1242/dev.047951 – volume: 529 start-page: 298 year: 2016 ident: 138_CR1 publication-title: Nature doi: 10.1038/nature17038 – volume: 473 start-page: 101 year: 2011 ident: 138_CR25 publication-title: Nature doi: 10.1038/nature09881 – volume: 505 start-page: 327 year: 2014 ident: 138_CR8 publication-title: Nature doi: 10.1038/nature12984 – volume: 23 start-page: 2278 year: 2009 ident: 138_CR42 publication-title: Genes Dev. doi: 10.1101/gad.535409 – volume: 14 start-page: 611 year: 2014 ident: 138_CR2 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3793 – volume: 554 start-page: 475 year: 2018 ident: 138_CR24 publication-title: Nature doi: 10.1038/nature25739 – volume: 102 start-page: 562 year: 2008 ident: 138_CR43 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.107.167908 – volume: 51 start-page: 354 year: 2007 ident: 138_CR53 publication-title: Histopathology doi: 10.1111/j.1365-2559.2007.02800.x – volume: 9 start-page: 1282 year: 2014 ident: 138_CR26 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.085 – volume: 123 start-page: 2509 year: 2013 ident: 138_CR68 publication-title: J. Clin. Invest. doi: 10.1172/JCI67250 – volume: 90 start-page: 1429 year: 2004 ident: 138_CR54 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6601727 – volume: 109 start-page: E2441 year: 2012 ident: 138_CR29 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1212021109 – volume: 22 start-page: 4918 year: 2002 ident: 138_CR45 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-12-04918.2002 – volume: 284 start-page: 1994 year: 1999 ident: 138_CR49 publication-title: Science doi: 10.1126/science.284.5422.1994 – volume: 151 start-page: 1417 year: 1997 ident: 138_CR48 publication-title: Am. J. Pathol. – volume: 5 start-page: 1704 year: 2013 ident: 138_CR71 publication-title: Cell Rep. doi: 10.1016/j.celrep.2013.11.020 – volume: 19 start-page: 50 year: 2013 ident: 138_CR59 publication-title: Nat. Med. doi: 10.1038/nm.3029 – volume: 138 start-page: 51 year: 2009 ident: 138_CR19 publication-title: Cell doi: 10.1016/j.cell.2009.04.030 – volume: 135 start-page: 738 year: 2008 ident: 138_CR64 publication-title: Cell doi: 10.1016/j.cell.2008.10.028 – volume: 3 start-page: 537 year: 2003 ident: 138_CR58 publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00132-6 – volume: 474 start-page: 179 year: 2011 ident: 138_CR32 publication-title: Nature doi: 10.1038/nature10137 – volume: 436 start-page: 518 year: 2005 ident: 138_CR21 publication-title: Nature doi: 10.1038/nature03799 – volume: 459 start-page: 1005 year: 2009 ident: 138_CR20 publication-title: Nature doi: 10.1038/nature08021 – volume: 154 start-page: 1060 year: 2013 ident: 138_CR66 publication-title: Cell doi: 10.1016/j.cell.2013.07.036 – volume: 168 start-page: 670 year: 2017 ident: 138_CR3 publication-title: Cell doi: 10.1016/j.cell.2016.11.037 – volume: 106 start-page: 10290 year: 2009 ident: 138_CR22 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0904227106 – volume: 122 start-page: 4009 year: 2009 ident: 138_CR46 publication-title: J. Cell Sci. doi: 10.1242/jcs.056770 – volume: 153 start-page: 139 year: 2013 ident: 138_CR55 publication-title: Cell doi: 10.1016/j.cell.2013.02.021 – volume: 16 start-page: 108 year: 2014 ident: 138_CR69 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2884 – volume: 1 start-page: 76 year: 2015 ident: 138_CR4 publication-title: Trends Cancer doi: 10.1016/j.trecan.2015.07.009 – volume: 36 start-page: 485 year: 2004 ident: 138_CR50 publication-title: Pathology doi: 10.1080/00313020412331282708 – volume: 154 start-page: 1047 year: 2013 ident: 138_CR34 publication-title: Cell doi: 10.1016/j.cell.2013.07.042 – volume: 2002 start-page: pl9 year: 2002 ident: 138_CR63 publication-title: Science’s STKE: Signal Transduct. Knowl. Environ. – volume: 11 start-page: 353 year: 2010 ident: 138_CR28 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2890 – volume: 4 start-page: e1086613 year: 2015 ident: 138_CR6 publication-title: Intravital doi: 10.1080/21659087.2015.1086613 – volume: 22 start-page: 1962 year: 2008 ident: 138_CR27 publication-title: Genes Dev. doi: 10.1101/gad.1664408 – volume: 15 start-page: 807 year: 2013 ident: 138_CR11 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2767 – volume: 23 start-page: 10419 year: 2003 ident: 138_CR39 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-32-10419.2003 – volume: 4 year: 2013 ident: 138_CR44 publication-title: Nat. Commun. doi: 10.1038/ncomms3976 – volume: 126 start-page: 3047 year: 1999 ident: 138_CR56 publication-title: Development doi: 10.1242/dev.126.14.3047 – volume: 135 start-page: 749 year: 2008 ident: 138_CR65 publication-title: Cell doi: 10.1016/j.cell.2008.10.029 – volume: 138 start-page: 1565 year: 2016 ident: 138_CR14 publication-title: Int. J. Cancer doi: 10.1002/ijc.29658 – volume: 16 start-page: 116 year: 2010 ident: 138_CR5 publication-title: Nat. Med. doi: 10.1038/nm.2072 – volume: 171 start-page: 1397 year: 2017 ident: 138_CR35 publication-title: Cell doi: 10.1016/j.cell.2017.10.008 – volume: 355 start-page: 1787 year: 2000 ident: 138_CR52 publication-title: Lancet doi: 10.1016/S0140-6736(00)02268-6 – volume: 13 start-page: 375 year: 2005 ident: 138_CR36 publication-title: Oncol. Rep. – volume: 26 start-page: 2508 year: 1996 ident: 138_CR15 publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830261035 – volume: 67 start-page: 519 year: 1992 ident: 138_CR41 publication-title: Lab. Invest. – volume: 21 start-page: 193 year: 2011 ident: 138_CR18 publication-title: Dev. Cell doi: 10.1016/j.devcel.2011.07.001 – volume: 69 start-page: 1334 year: 2009 ident: 138_CR47 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-3051 – volume: 156 start-page: 1002 year: 2014 ident: 138_CR13 publication-title: Cell doi: 10.1016/j.cell.2014.01.040 – volume: 529 start-page: 316 year: 2016 ident: 138_CR9 publication-title: Nature doi: 10.1038/nature17040 – volume: 167 start-page: 1525 year: 2016 ident: 138_CR57 publication-title: Cell doi: 10.1016/j.cell.2016.11.005 – volume: 6 start-page: 374 year: 2012 ident: 138_CR17 publication-title: Cell Adhes. Migr. doi: 10.4161/cam.20832 – volume: 165 start-page: 45 year: 2016 ident: 138_CR10 publication-title: Cell doi: 10.1016/j.cell.2016.02.025 – volume: 11 start-page: 257 year: 2009 ident: 138_CR30 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1833 – volume: 291 start-page: 334 year: 1981 ident: 138_CR60 publication-title: Nature doi: 10.1038/291334a0 – volume: 24 start-page: 862 year: 2010 ident: 138_CR33 publication-title: Genes Dev. doi: 10.1101/gad.1909210 – volume: 117 start-page: 461 year: 1992 ident: 138_CR61 publication-title: J. Cell Biol. doi: 10.1083/jcb.117.2.461 – volume: 6 start-page: 19 year: 2013 ident: 138_CR51 publication-title: Cancer Microenviron. doi: 10.1007/s12307-012-0128-5 – volume: 2 start-page: 427 year: 2013 ident: 138_CR12 publication-title: Cancer Med. doi: 10.1002/cam4.105 – volume: 17 start-page: 346 year: 1997 ident: 138_CR16 publication-title: Nat. Genet. doi: 10.1038/ng1197-346 – volume: 24 start-page: 481 year: 2013 ident: 138_CR23 publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.08.012 – volume: 15 year: 2014 ident: 138_CR67 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 17 start-page: 981 year: 2010 ident: 138_CR31 publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2010.07.009 – reference: 30038255 - Nat Cell Biol. 2018 Aug;20(8):860-862 – reference: 30542103 - Nat Cell Biol. 2019 Mar;21(3):408
SSID	ssj0014407
Score	2.6409042
Snippet	Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the... Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signaling triggered by the...
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	966
SubjectTerms	13/1 13/105 13/106 13/109 13/31 13/89 13/95 14/1 14/19 14/35 59 59/5 631/67 631/67/322 631/80/79/2066 631/80/86 82 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - secondary Cancer Cancer Research Capillaries Capillaries - metabolism Capillaries - pathology Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cell Biology Cell Communication Cell Movement Cell Proliferation Cell Shape Colonization Developmental Biology Female HCT116 Cells HEK293 Cells Humans ILK protein Infiltration Integrin beta1 - genetics Integrin beta1 - metabolism Invasiveness Kinases Latency Life Sciences Male Mechanotransduction Mechanotransduction, Cellular Metastases Metastasis Mice, Inbred C57BL Mice, Inbred NOD Molecular chains Neural cell adhesion molecule Neural Cell Adhesion Molecule L1 - genetics Neural Cell Adhesion Molecule L1 - metabolism Organs Pericytes Pericytes - metabolism Pericytes - pathology Phosphoproteins - genetics Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Signaling Spreading Stem Cells Time Factors Tissue Culture Techniques Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors Tumor Microenvironment Yes-associated protein
Title	Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization
URI	https://link.springer.com/article/10.1038/s41556-018-0138-8 https://www.ncbi.nlm.nih.gov/pubmed/30038252 https://www.proquest.com/docview/2076903381 https://www.proquest.com/docview/2075546933 https://pubmed.ncbi.nlm.nih.gov/PMC6467203
Volume	20
WOSCitedRecordID	wos000440057000015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4679 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0014407 issn: 1465-7392 databaseCode: M7P dateStart: 19990501 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4679 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0014407 issn: 1465-7392 databaseCode: 7X7 dateStart: 19990501 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4679 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0014407 issn: 1465-7392 databaseCode: BENPR dateStart: 19990501 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEB7RFqReKG8CJVokTiAL27vOrk-orRpxgMiqCgony_swRBSnjd1K-ffMrB9VWtELlyiSN8luZnbm2_3mAfBOIMpIJI-CNNU8EAUPA1RlG4ShtcLZ0LWJtN-_yNlMzedp1l241V1YZW8TvaG2S0N35HQTggc5PFBFn84vAuoaRexq10JjC3aoSkLsQ_eygUUQwqdLozFIAolAoGc1ufpYkyOlszSFcuGeV5t-6RbYvB0zeYM49f5ouve_K3kEDzskyg5a1XkM91z1BB60vSnXT-FnRlTOunHB2eK3YziNNtye6TXzJD7F0CBcZYb0ZsWIAagZpUlcEXxlPw4yVlSWfT05nTJExuyPawpKX1oYRpWy-wTQZ_Btenx69DnoujIERsSyQZcmikKFhgqj2UmIbycGUZ0VepImLtJOkxVxZZlq5aSNSmVSl6QWzZkwEaKt57BdLSv3Elhk8fzNbWxiqUUhtTZofUpR2IjLtCz5CMJeJrnpSpZT54yz3FPnXOWtGHMUY05izNUI3g8fOW_rddw1eL-XUN5t3Tq_Fs8I3g6PcdPR_1hUbnnpx1B0X8pxii9avRh-jRPZGifxCOSGxgwDqKD35pNq8csX9p6g14pD_M4PvW5dT-ufi3h19yJew27stZwUfR-2m9WlewP3zVWzqFdj2JJz6V_VGHYOj2fZydjvob-Gdh7D
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5VBQSX8oYtBYwEF1BEEjuxc0CoAlatul2t0IKWU5rYDqxos2WTtto_xW9kJt6kWip664FbpDgPJ998nvG8AF4K1DIiyQMvSXLuiYz7HkLZeL5vjLDGty6R9utADodqMklGa_C7zYWhsMqWExuiNjNNe-S0E4KGHBpUwfvjXx51jSLvattCw8Fizy7O0GSr3u1-xP_7Kgz7n8YfdrxlVwFPi1DWSMkiy5SvqbCXiX08jDVqJUbkcRLZILc5SYEtiiRXVpqgUDqxUWJQHIUOYip0gJR_DXlckrEnJ52BR35S6bKZIk-i4tF6Ubl6W9HCTbY7hY4hx6jVdfCCcnsxRvMvR22z_vVv_29f7g5sLDVttu1E4y6s2fIe3HC9Nxf34fuIXFWL2nqH05-W4bRdOgHLF6wJUqAYIVTHmSa5mDPycFSM0kBOST1n37ZHLCsN2_887jPU_NmRrTNKz5pqRpXA2wTXB_DlSmb5ENbLWWkfAwuMUoqbUIcyF5nMc43sWojMBFwmRcF74LcYSPWyJDt1BjlMm9AArlIHmxRhkxJsUtWD190lx64eyWWDt1pEpEtqqtJzOPTgRXcaSYW-Y1ba2UkzhqIXE46v-MjhsHsaJ2dyGIU9kCsI7QZQwfLVM-X0R1O4PMZVOfTxnm9aLJ-_1j8nsXn5JJ7DzZ3x_iAd7A73nsCtsJEwErItWK_nJ_YpXNen9bSaP2tklcHBVUP8D7Sjd5U
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB5V24K4lDcsFDASXEBRk9hJnANCpe2KqmUVVQW1J5PYDqxos2WTFu1f49cxk1e1VPTWA7dIcR52vvk8k3kBvBKoZQQR95w4zrgjUu46CGXjuK4xwhrXNom0X_ai8VgeHsbJEvzucmEorLLjxJqozVTTP3L6E4KGHBpU3nrehkUkW6P3pz8d6iBFntaunUYDkV07_4XmW_luZwu_9WvfH20fbH502g4DjhZ-VCE9izSVrqYiXyZ08TDUqKEYkYVxYL3MZiQRNs_jTNrIeLnUsQ1ig6IptBdS0QOk_-UIlQwxgOUP2-Nkv_dhCFEnayMVBQ6N6HyqXK6XtI2TJU-BZMg4cnFXvKTqXo7Y_MttW--Go9v_8zregdVWB2cbjdDchSVb3IMbTVfO-X34lpATa15Z53jywzJcgibRgGVzVocvUPQQKupMk8TMGPk-SkYJIuekuLOjjYSlhWGf9g9GDG0CdmKrlBK3JppRjfAu9fUBfL6WWT6EQTEt7GNgnpFScuNrP8pEGmWZRt7NRWo8HsV5zofgdnhQui3WTj1DjlUdNMClaiCkEEKKIKTkEN70l5w2lUquGrzWoUO1pFWqC2gM4WV_GumG1jEt7PSsHkNxjTHHV3zUYLJ_Gic3sx_4Q4gW0NoPoFLmi2eKyfe6pHmI-7Xv4j3fdri-eK1_TuLJ1ZN4ATcR2WpvZ7z7FG75tbCRvK3BoJqd2Wewos-rSTl73goug6_XjfE_I7iBtQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pericyte-Like+Spreading+by+Disseminated+Cancer+Cells+Activates+YAP+and+MRTF+for+Metastatic+Colonization&rft.jtitle=Nature+cell+biology&rft.au=Er%2C+Ekrem+Emrah&rft.au=Valiente%2C+Manuel&rft.au=Ganesh%2C+Karuna&rft.au=Zou%2C+Yilong&rft.date=2018-08-01&rft.issn=1465-7392&rft.eissn=1476-4679&rft.volume=20&rft.issue=8&rft.spage=966&rft.epage=978&rft_id=info:doi/10.1038%2Fs41556-018-0138-8&rft_id=info%3Apmid%2F30038252&rft.externalDocID=PMC6467203
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1465-7392&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1465-7392&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1465-7392&client=summon