Exploration of synthetic lethal interactions as cancer drug targets

In cancer research the quest continues to identify the Achilles heel of cancer. The ideal cancer drug targets are those that are essential in tumor cells but not in normal cells. Such targets are defined as cancer-specific vulnerabilities or as synthetic lethal interactions with cancer-specific gene...

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Bibliographic Details
Published in:	Future oncology (London, England) Vol. 6; no. 11; pp. 1789 - 1802
Main Authors:	Kuiken, Hendrik J, Beijersbergen, Roderick L
Format:	Journal Article
Language:	English
Published:	England Future Medicine Ltd 01.11.2010
Subjects:	(non)oncogene addiction Animals Antimitotic agents Antineoplastic agents chemical-genetic Development and progression Drug interactions Drug Screening Assays, Antitumor - methods Drug therapy Genes, ras - physiology Genetic Testing Health aspects Humans Molecular Targeted Therapy Neoplasms - genetics Neoplasms - therapy network addiction RAS RNA Interference RNAi screen shRNA siRNA synthetic lethal interaction Tumors Netherlands
ISSN:	1479-6694, 1744-8301, 1744-8301
Online Access:	Get full text
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