Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease

In a 2-by-2 factorial trial, 12,705 persons at intermediate risk were assigned to candesartan plus hydrochlorothiazide or placebo and to rosuvastatin or placebo. At 5.6 years, combination therapy resulted in a significantly lower risk of cardiovascular events than dual placebo. Cardiovascular diseas...

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Vydáno v:	The New England journal of medicine Ročník 374; číslo 21; s. 2032 - 2043
Hlavní autoři:	Yusuf, Salim, Lonn, Eva, Pais, Prem, Bosch, Jackie, López-Jaramillo, Patricio, Zhu, Jun, Xavier, Denis, Avezum, Alvaro, Leiter, Lawrence A, Piegas, Leopoldo S, Parkhomenko, Alexander, Keltai, Matyas, Keltai, Katalin, Sliwa, Karen, Chazova, Irina, Peters, Ron J.G, Held, Claes, Yusoff, Khalid, Lewis, Basil S, Jansky, Petr, Khunti, Kamlesh, Toff, William D, Reid, Christopher M, Varigos, John, Accini, Jose L, McKelvie, Robert, Pogue, Janice, Jung, Hyejung, Liu, Lisheng, Diaz, Rafael, Dans, Antonio, Dagenais, Gilles
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Massachusetts Medical Society 26.05.2016
Témata:	Aged Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensives Benzimidazoles - administration & dosage Blood pressure Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Cerebral infarction Cholesterol Cholesterol, LDL - blood Disease prevention Double-Blind Method Drug therapy Drug Therapy, Combination Female Health risk assessment Heart diseases Humans Hydrochlorothiazide Hydrochlorothiazide - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hypertension - drug therapy Lipids Low density lipoprotein Male Medication Adherence Middle Aged Myocardial infarction Risk Factors Rosuvastatin Calcium - administration & dosage Rosuvastatin Calcium - adverse effects Stroke Tetrazoles - administration & dosage
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
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