Investigating the impact of platelet transfusions on adverse outcomes in patients with thrombotic thrombocytopenic purpura: A systematic review of published studies

•Whether platelet transfusions are harmful to TTP patients is currently unclear.•To address this gap, we carried out a systematic review, retrieving 11 eligible studies.•We found that the all-cause mortality of transfused patients was significantly higher compared to non-transfused patients.•There w...

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Bibliographic Details
Published in:Thrombosis research Vol. 253; p. 109413
Main Authors: Clerici, Bianca, Tarasconi, Elisa, Benedetto, Chiara, Pisetta, Chiara, Birocchi, Simone, Podda, Gian Marco
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 01.09.2025
Subjects:
Hematology, Oncology, and Palliative Medicine
Platelet transfusion
Purpura, Thrombotic thrombocytopenic
Systematic review
Systematic review
Purpura, Thrombotic thrombocytopenic
Platelet transfusion
ISSN:0049-3848, 1879-2472, 1879-2472
Online Access:Get full text
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Summary:•Whether platelet transfusions are harmful to TTP patients is currently unclear.•To address this gap, we carried out a systematic review, retrieving 11 eligible studies.•We found that the all-cause mortality of transfused patients was significantly higher compared to non-transfused patients.•There were no significant differences in the rates of other target organ complications.•Our results could signify harm of platelet transfusions or a greater disease severity of transfused TTP patients.
Bibliography:content type line 23
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
ISSN:0049-3848
1879-2472
1879-2472
DOI:10.1016/j.thromres.2025.109413