Investigating the impact of platelet transfusions on adverse outcomes in patients with thrombotic thrombocytopenic purpura: A systematic review of published studies

•Whether platelet transfusions are harmful to TTP patients is currently unclear.•To address this gap, we carried out a systematic review, retrieving 11 eligible studies.•We found that the all-cause mortality of transfused patients was significantly higher compared to non-transfused patients.•There w...

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Vydáno v:Thrombosis research Ročník 253; s. 109413
Hlavní autoři: Clerici, Bianca, Tarasconi, Elisa, Benedetto, Chiara, Pisetta, Chiara, Birocchi, Simone, Podda, Gian Marco
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Ltd 01.09.2025
Témata:
Hematology, Oncology, and Palliative Medicine
Platelet transfusion
Purpura, Thrombotic thrombocytopenic
Systematic review
Systematic review
Purpura, Thrombotic thrombocytopenic
Platelet transfusion
ISSN:0049-3848, 1879-2472, 1879-2472
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Abstract •Whether platelet transfusions are harmful to TTP patients is currently unclear.•To address this gap, we carried out a systematic review, retrieving 11 eligible studies.•We found that the all-cause mortality of transfused patients was significantly higher compared to non-transfused patients.•There were no significant differences in the rates of other target organ complications.•Our results could signify harm of platelet transfusions or a greater disease severity of transfused TTP patients.
AbstractList Highlights•Whether platelet transfusions are harmful to TTP patients is currently unclear. •To address this gap, we carried out a systematic review, retrieving 11 eligible studies. •We found that the all-cause mortality of transfused patients was significantly higher compared to non-transfused patients. •There were no significant differences in the rates of other target organ complications. •Our results could signify harm of platelet transfusions or a greater disease severity of transfused TTP patients.
•Whether platelet transfusions are harmful to TTP patients is currently unclear.•To address this gap, we carried out a systematic review, retrieving 11 eligible studies.•We found that the all-cause mortality of transfused patients was significantly higher compared to non-transfused patients.•There were no significant differences in the rates of other target organ complications.•Our results could signify harm of platelet transfusions or a greater disease severity of transfused TTP patients.
ArticleNumber 109413
Author Tarasconi, Elisa
Birocchi, Simone
Podda, Gian Marco
Pisetta, Chiara
Clerici, Bianca
Benedetto, Chiara
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Cites_doi 10.1002/ajh.23997
10.1055/s-2007-1005063
10.1007/s00467-013-2414-y
10.1055/s-2007-1005066
10.1182/blood-2014-10-605493
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10.1001/jama.1981.03320170043028
10.1111/j.1537-2995.2008.02082.x
10.1111/j.1537-2995.2008.01822.x
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Keywords Systematic review
Purpura, Thrombotic thrombocytopenic
Platelet transfusion
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Platelet transfusion
Purpura, Thrombotic thrombocytopenic
Systematic review
Title Investigating the impact of platelet transfusions on adverse outcomes in patients with thrombotic thrombocytopenic purpura: A systematic review of published studies
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