Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

Under normal physiological conditions, cellular homeostasis is partly regulated by a balance of pro- and anti-phagocytic signals. CD47, which prevents cancer cell phagocytosis by the innate immune system, is highly expressed on several human cancers including acute myeloid leukemia, non-Hodgkin'...

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Bibliographic Details

Published in:	Science translational medicine Vol. 2; no. 63; p. 63ra94
Main Authors:	Chao, Mark P, Jaiswal, Siddhartha, Weissman-Tsukamoto, Rachel, Alizadeh, Ash A, Gentles, Andrew J, Volkmer, Jens, Weiskopf, Kipp, Willingham, Stephen B, Raveh, Tal, Park, Christopher Y, Majeti, Ravindra, Weissman, Irving L
Format:	Journal Article
Language:	English
Published:	United States 22.12.2010
Subjects:	Animals Calreticulin - metabolism CD47 Antigen - metabolism Cell Line Cell Line, Tumor Flow Cytometry Humans In Vitro Techniques Leukemia, Myeloid, Acute - metabolism Lymphoma, Non-Hodgkin - metabolism Mice Phagocytosis - physiology Urinary Bladder Neoplasms - metabolism
ISSN:	1946-6242, 1946-6242
Online Access:	Get more information
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