Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

Parkinson's disease is a progressive neurodegenerative disorder characterized by altered striatal dopaminergic signalling that leads to motor and cognitive deficits. Parkinson's disease is also characterized by abnormal presence of soluble toxic forms of α-synuclein that, when clustered in...

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Bibliographic Details
Published in:	Brain (London, England : 1878) Vol. 142; no. 5; p. 1365
Main Authors:	Durante, Valentina, de Iure, Antonio, Loffredo, Vittorio, Vaikath, Nishant, De Risi, Maria, Paciotti, Silvia, Quiroga-Varela, Ana, Chiasserini, Davide, Mellone, Manuela, Mazzocchetti, Petra, Calabrese, Valeria, Campanelli, Federica, Mechelli, Alessandro, Di Filippo, Massimiliano, Ghiglieri, Veronica, Picconi, Barbara, El-Agnaf, Omar M, De Leonibus, Elvira, Gardoni, Fabrizio, Tozzi, Alessandro, Calabresi, Paolo
Format:	Journal Article
Language:	English
Published:	England 01.05.2019
Subjects:	alpha-Synuclein - administration & dosage alpha-Synuclein - toxicity Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - pathology Humans Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Mice Mice, Transgenic Organ Culture Techniques Protein Subunits - antagonists & inhibitors Protein Subunits - metabolism Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Spatial Memory - drug effects Spatial Memory - physiology Synapses - drug effects Synapses - physiology Visual Perception - drug effects Visual Perception - physiology dopamine Parkinson’s disease glutamate long-term potentiation monoclonal antibodies
ISSN:	1460-2156, 1460-2156
Online Access:	Get more information
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