Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression

DNA methylation of the FKBP5 gene is assumed to alter FKBP5 expression and hence the synthesis of the FK506 binding protein 51, a central element of a genomic negative feedback loop for glucocorticoid receptor signaling. The present study aimed to replicate and extend previously reported influences...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 44; no. 5; pp. 930 - 938
Main Authors:	Klinger-König, Johanna, Hertel, Johannes, Van der Auwera, Sandra, Frenzel, Stefan, Pfeiffer, Liliane, Waldenberger, Melanie, Golchert, Janine, Teumer, Alexander, Nauck, Matthias, Homuth, Georg, Völzke, Henry, Grabe, Hans J
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2019
Subjects:	Adult Adult Survivors of Child Abuse - statistics & numerical data Adverse Childhood Experiences - statistics & numerical data Aged Childhood Children CpG islands Depressive Disorder - epidemiology Depressive Disorder - etiology Depressive Disorder - genetics DNA methylation DNA Methylation - genetics Female Follow-Up Studies Gene polymorphism Germany - epidemiology Glucocorticoids Humans Long-term effects Male Mental depression Middle Aged Registries Single-nucleotide polymorphism Tacrolimus Tacrolimus Binding Proteins - genetics Tacrolimus-binding protein Young Adult Germany
ISSN:	0893-133X, 1740-634X, 1740-634X
Online Access:	Get full text
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