Advance on the Flavonoid C-glycosides and Health Benefits

The dietary flavonoids, especially their glycosides, are the most vital phytochemicals in diets and are of great general interest due to their diverse bioactivity. Almost all natural flavonoids exist as their O-glycoside or C-glycoside forms in plants. The dietary flavonoid C-glycosides have receive...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition Vol. 56; no. sup1; pp. S29 - S45
Main Authors: Xiao, Jianbo, Capanoglu, Esra, Jassbi, Amir Reza, Miron, Anca
Format: Journal Article
Language:English
Published: United States Taylor & Francis 29.07.2016
Taylor & Francis Ltd
Subjects:
absorption
Aging - drug effects
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Anti-Infective Agents - pharmacology
anti-inflammatory activity
Anti-Inflammatory Agents - pharmacology
antifungal properties
antineoplastic activity
Antineoplastic Agents - pharmacology
antioxidant activity
Antioxidants
Antiparasitic Agents - pharmacology
Antiviral Agents - pharmacology
antiviral properties
biological benefits
Biological effects
blood
Diabetes
diet
Flavonoid C-glycosides
Flavonoids
Flavonoids - pharmacology
glycosides
Healthy Diet
hepatoprotective effect
human health
Humans
Hypoglycemic Agents - pharmacology
intestinal microorganisms
intestines
Metabolites
Monosaccharides - pharmacology
Phytochemicals - pharmacology
phytopharmaceuticals
Plant Extracts - pharmacology
Platelet Aggregation Inhibitors - pharmacology
stability
tissues
urine
Flavonoid C-glycosides
absorption
biological benefits
stability
ISSN:1040-8398, 1549-7852, 1549-7852
Online Access:Get full text
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Summary:The dietary flavonoids, especially their glycosides, are the most vital phytochemicals in diets and are of great general interest due to their diverse bioactivity. Almost all natural flavonoids exist as their O-glycoside or C-glycoside forms in plants. The dietary flavonoid C-glycosides have received less attention than their corresponding O-glycosides. This review summarizes current knowledge regarding flavonoid C-glycosides and their influence on human health. Among the flavonoid C-glycosides, flavone C-glycosides, especially vitexin, isoorientin, orientin, isovitexin and their multiglycosides are more frequently mentioned than others. Flavonoid C-monoglycosides are poorly absorbed in human beings with very few metabolites in urine and blood and are deglycosylated and degraded by human intestinal bacteria in colon. However, flavonoid C-multiglycosides are absorbed unchanged in the intestine and distributed to other tissues. Flavonoid C-glycosides showed significant antioxidant activity, anticancer and antitumor activity, hepatoprotective activity, anti-inflammatory activity, anti-diabetes activity, antiviral activity, antibacterial and antifungal activity, and other biological effects. It looks like that the C-glycosylflavonoids in most cases showed higher antioxidant and anti-diabetes potential than their corresponding O-glycosylflavonoids and aglycones. However, there is a lack of in vivo data on the biological benefits of flavonoid C-glycosides. It is necessary to investigate more on how flavonoid C-glycosides prevent and handle the diseases.
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ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2015.1067595