Regulation of insulin receptor substrate-1 expression levels by caveolin-1

The insulin receptor substrate‐1 (IRS‐1), a docking protein of the type 1 insulin‐like growth factor receptor (IGF‐IR) plays a significant role in cell proliferation and differentiation. The expression of IRS‐1 is down‐regulated in mouse embryo fibroblasts (MEFs) with a deletion of caveolin‐1 (cav1)...

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Vydáno v:	Journal of cellular physiology Ročník 217; číslo 1; s. 281 - 289
Hlavní autoři:	Chen, Jia, Capozza, Franco, Wu, An, deAngelis, Tiziana, Sun, Hongzhi, Lisanti, Michael, Baserga, Renato
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2008
Témata:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Blotting, Western Caveolin 1 - metabolism Cell Differentiation - physiology Cell Proliferation Down-Regulation Embryo, Mammalian Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Gene Expression Regulation Immunoprecipitation Insulin Receptor Substrate Proteins Mice Mice, Knockout RNA Interference RNA, Messenger - analysis RNA, Small Interfering Transfection
ISSN:	0021-9541, 1097-4652, 1097-4652
On-line přístup:	Získat plný text
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