Neuro-immune crosstalk in depressive symptoms of multiple sclerosis

Depressive disorders can occur in up to 50% of people with multiple sclerosis in their lifetime. If left untreated, comorbid major depressive disorders may not spontaneously remit and is associated with an increased morbidity and mortality. Conversely, epidemiological evidence supports increased psy...

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Bibliographic Details
Published in:Neurobiology of disease Vol. 177; p. 106005
Main Authors: Wang, Chao, Zhou, Yulin, Feinstein, Anthony
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.02.2023
Elsevier
Subjects:
Adaptive and innate immune responses
Antidepressive Agents - therapeutic use
Comorbidity
Demyelination
Depression
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - psychology
Humans
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
Neuroimmune crosstalk
Depression
Multiple sclerosis
Neuroimmune crosstalk
Adaptive and innate immune responses
Comorbidity
Demyelination
ISSN:0969-9961, 1095-953X, 1095-953X
Online Access:Get full text
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Summary:Depressive disorders can occur in up to 50% of people with multiple sclerosis in their lifetime. If left untreated, comorbid major depressive disorders may not spontaneously remit and is associated with an increased morbidity and mortality. Conversely, epidemiological evidence supports increased psychiatric visit as a significant prodromal event prior to diagnosis of MS. Are there common molecular pathways that contribute to the co-development of MS and psychiatric illnesses? We discuss immune cells that are dysregulated in MS and how such dysregulation can induce or protect against depressive symptoms. This is not meant to be a comprehensive review of all molecular pathways but rather a framework to guide future investigations of immune responses in depressed versus euthymic people with MS. Currently, there is weak evidence supporting the use of antidepressant medication in comorbid MS patients. It is our hope that by better understanding the neuroimmune crosstalk in the context of depression in MS, we can enhance the potential for future therapeutic options. •People with MS are 2–3 times more likely to develop MDD compared to the general popualtion.•Depression and MS share certain key immune system changes,•There is equivocal evidence supporting the effectiveness of antidepressant medication in MS-related depression.•Selected Disease Modifying Therapies may improve depression in people with MS.
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ISSN:0969-9961
1095-953X
1095-953X
DOI:10.1016/j.nbd.2023.106005