Articular cartilage: evaluation with fluid-suppressed 7.0-T sodium MR imaging in subjects with and subjects without osteoarthritis

To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T. The study was approved by the institutional review board and was complian...

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Published in:Radiology Vol. 268; no. 2; p. 481
Main Authors: Madelin, Guillaume, Babb, James, Xia, Ding, Chang, Gregory, Krasnokutsky, Svetlana, Abramson, Steven B, Jerschow, Alexej, Regatte, Ravinder R
Format: Journal Article
Language:English
Published: United States 01.08.2013
Subjects:
Adult
Aged
Aged, 80 and over
Area Under Curve
Cartilage, Articular - pathology
Case-Control Studies
Female
Humans
Image Interpretation, Computer-Assisted
Logistic Models
Magnetic Resonance Imaging - methods
Male
Middle Aged
Osteoarthritis, Knee - pathology
Phantoms, Imaging
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
Sodium - metabolism
ISSN:1527-1315, 1527-1315
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Abstract To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T. The study was approved by the institutional review board and was compliant with HIPAA. The knee cartilage of 19 asymptomatic (control subjects) and 28 symptomatic (osteoarthritis patients) subjects underwent 7.0-T sodium MR imaging with use of two different sequences: one without fluid suppression (radial three-dimensional sequence) and one with fluid suppression (inversion recovery [IR] wideband uniform rate and smooth truncation [WURST]). Fluid suppression was obtained by using IR with an adiabatic inversion pulse (WURST pulse). Mean sodium concentrations and their standard deviations were measured in the patellar, femorotibial medial, and lateral cartilage regions over four consecutive sections for each subject. The minimum, maximum, median, and average means and standard deviations were calculated over all measurements for each subject. The utility of these measures in the detection of osteoarthritis was evaluated by using logistic regression and the area under the receiver operating characteristic curve (AUC). Bonferroni correction was applied to the P values obtained with logistic regression. Measurements from IR WURST were found to be significant predicators of all osteoarthritis (Kellgren-Lawrence score of 1-4) and early osteoarthritis (Kellgren-Lawrence score of 1 or 2). The minimum standard deviation provided the highest AUC (0.83) with the highest accuracy (>78%), sensitivity (>82%), and specificity (>74%) for both all osteoarthritis and early osteoarthritis groups. Quantitative sodium MR imaging at 7.0 T with fluid suppression by using adiabatic IR is a potential biomarker for osteoarthritis.
AbstractList To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T. The study was approved by the institutional review board and was compliant with HIPAA. The knee cartilage of 19 asymptomatic (control subjects) and 28 symptomatic (osteoarthritis patients) subjects underwent 7.0-T sodium MR imaging with use of two different sequences: one without fluid suppression (radial three-dimensional sequence) and one with fluid suppression (inversion recovery [IR] wideband uniform rate and smooth truncation [WURST]). Fluid suppression was obtained by using IR with an adiabatic inversion pulse (WURST pulse). Mean sodium concentrations and their standard deviations were measured in the patellar, femorotibial medial, and lateral cartilage regions over four consecutive sections for each subject. The minimum, maximum, median, and average means and standard deviations were calculated over all measurements for each subject. The utility of these measures in the detection of osteoarthritis was evaluated by using logistic regression and the area under the receiver operating characteristic curve (AUC). Bonferroni correction was applied to the P values obtained with logistic regression. Measurements from IR WURST were found to be significant predicators of all osteoarthritis (Kellgren-Lawrence score of 1-4) and early osteoarthritis (Kellgren-Lawrence score of 1 or 2). The minimum standard deviation provided the highest AUC (0.83) with the highest accuracy (>78%), sensitivity (>82%), and specificity (>74%) for both all osteoarthritis and early osteoarthritis groups. Quantitative sodium MR imaging at 7.0 T with fluid suppression by using adiabatic IR is a potential biomarker for osteoarthritis.
To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T.PURPOSETo assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for classifying subjects with versus subjects without osteoarthritis at 7.0 T.The study was approved by the institutional review board and was compliant with HIPAA. The knee cartilage of 19 asymptomatic (control subjects) and 28 symptomatic (osteoarthritis patients) subjects underwent 7.0-T sodium MR imaging with use of two different sequences: one without fluid suppression (radial three-dimensional sequence) and one with fluid suppression (inversion recovery [IR] wideband uniform rate and smooth truncation [WURST]). Fluid suppression was obtained by using IR with an adiabatic inversion pulse (WURST pulse). Mean sodium concentrations and their standard deviations were measured in the patellar, femorotibial medial, and lateral cartilage regions over four consecutive sections for each subject. The minimum, maximum, median, and average means and standard deviations were calculated over all measurements for each subject. The utility of these measures in the detection of osteoarthritis was evaluated by using logistic regression and the area under the receiver operating characteristic curve (AUC). Bonferroni correction was applied to the P values obtained with logistic regression.MATERIALS AND METHODSThe study was approved by the institutional review board and was compliant with HIPAA. The knee cartilage of 19 asymptomatic (control subjects) and 28 symptomatic (osteoarthritis patients) subjects underwent 7.0-T sodium MR imaging with use of two different sequences: one without fluid suppression (radial three-dimensional sequence) and one with fluid suppression (inversion recovery [IR] wideband uniform rate and smooth truncation [WURST]). Fluid suppression was obtained by using IR with an adiabatic inversion pulse (WURST pulse). Mean sodium concentrations and their standard deviations were measured in the patellar, femorotibial medial, and lateral cartilage regions over four consecutive sections for each subject. The minimum, maximum, median, and average means and standard deviations were calculated over all measurements for each subject. The utility of these measures in the detection of osteoarthritis was evaluated by using logistic regression and the area under the receiver operating characteristic curve (AUC). Bonferroni correction was applied to the P values obtained with logistic regression.Measurements from IR WURST were found to be significant predicators of all osteoarthritis (Kellgren-Lawrence score of 1-4) and early osteoarthritis (Kellgren-Lawrence score of 1 or 2). The minimum standard deviation provided the highest AUC (0.83) with the highest accuracy (>78%), sensitivity (>82%), and specificity (>74%) for both all osteoarthritis and early osteoarthritis groups.RESULTSMeasurements from IR WURST were found to be significant predicators of all osteoarthritis (Kellgren-Lawrence score of 1-4) and early osteoarthritis (Kellgren-Lawrence score of 1 or 2). The minimum standard deviation provided the highest AUC (0.83) with the highest accuracy (>78%), sensitivity (>82%), and specificity (>74%) for both all osteoarthritis and early osteoarthritis groups.Quantitative sodium MR imaging at 7.0 T with fluid suppression by using adiabatic IR is a potential biomarker for osteoarthritis.CONCLUSIONQuantitative sodium MR imaging at 7.0 T with fluid suppression by using adiabatic IR is a potential biomarker for osteoarthritis.
Author Chang, Gregory
Krasnokutsky, Svetlana
Xia, Ding
Jerschow, Alexej
Babb, James
Regatte, Ravinder R
Madelin, Guillaume
Abramson, Steven B
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  surname: Madelin
  fullname: Madelin, Guillaume
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  organization: Department of Radiology, New York University Langone Medical Center, 660 First Ave, 4th Floor, New York, NY 10016, USA. guillaume.madelin@nyumc.org
– sequence: 2
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References 21853493 - NMR Biomed. 2012 Apr;25(4):530-7
12464550 - Osteoarthritis Cartilage. 2002 Dec;10(12):907-13
18163497 - Arthritis Rheum. 2008 Jan;58(1):26-35
17075961 - NMR Biomed. 2006 Nov;19(7):781-821
8916016 - Magn Reson Med. 1996 Nov;36(5):665-73
20813569 - J Magn Reson. 2010 Nov;207(1):42-52
19696274 - AJR Am J Roentgenol. 2009 Sep;193(3):628-38
14519880 - Radiology. 2003 Oct;229(1):269-74
21630094 - MAGMA. 2011 Aug;24(4):247-58
18590824 - Pharmacol Res. 2008 Jul;58(1):1-7
11810671 - Magn Reson Med. 2002 Feb;47(2):284-91
12147862 - Radiology. 2002 Aug;224(2):598-602
15163825 - Radiology. 2004 Jun;231(3):900-5
11436214 - J Magn Reson Imaging. 2001 Jul;14(1):50-5
15844163 - Magn Reson Med. 2005 May;53(5):993-8
1309384 - J Orthop Res. 1992 Jan;10(1):1-13
18850506 - Semin Musculoskelet Radiol. 2008 Sep;12(3):266-80
2581923 - Histochemistry. 1985;82(3):249-55
10025608 - Magn Reson Med. 1999 Jan;41(1):30-4
18268341 - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2266-70
17969013 - Magn Reson Med. 2007 Dec;58(6):1182-95
22204825 - J Magn Reson. 2012 Jan;214(1):360-5
13498604 - Ann Rheum Dis. 1957 Dec;16(4):494-502
16385518 - Arthritis Rheum. 2006 Jan;54(1):226-9
19950287 - Arthritis Rheum. 2009 Dec;60(12):3546-53
22887123 - Magn Reson Med. 2013 Jul;70(1):259-68
19934104 - Ann Rheum Dis. 2010 May;69(5):856-61
10617432 - J Magn Reson. 2000 Jan;142(1):24-31
3741515 - Arthritis Rheum. 1986 Aug;29(8):1039-49
9581599 - Magn Reson Med. 1998 May;39(5):697-701
17191248 - Magn Reson Med. 2007 Jan;57(1):74-81
References_xml – reference: 2581923 - Histochemistry. 1985;82(3):249-55
– reference: 8916016 - Magn Reson Med. 1996 Nov;36(5):665-73
– reference: 18850506 - Semin Musculoskelet Radiol. 2008 Sep;12(3):266-80
– reference: 21630094 - MAGMA. 2011 Aug;24(4):247-58
– reference: 22204825 - J Magn Reson. 2012 Jan;214(1):360-5
– reference: 21853493 - NMR Biomed. 2012 Apr;25(4):530-7
– reference: 13498604 - Ann Rheum Dis. 1957 Dec;16(4):494-502
– reference: 12464550 - Osteoarthritis Cartilage. 2002 Dec;10(12):907-13
– reference: 11436214 - J Magn Reson Imaging. 2001 Jul;14(1):50-5
– reference: 11810671 - Magn Reson Med. 2002 Feb;47(2):284-91
– reference: 19696274 - AJR Am J Roentgenol. 2009 Sep;193(3):628-38
– reference: 3741515 - Arthritis Rheum. 1986 Aug;29(8):1039-49
– reference: 17191248 - Magn Reson Med. 2007 Jan;57(1):74-81
– reference: 15163825 - Radiology. 2004 Jun;231(3):900-5
– reference: 18163497 - Arthritis Rheum. 2008 Jan;58(1):26-35
– reference: 22887123 - Magn Reson Med. 2013 Jul;70(1):259-68
– reference: 20813569 - J Magn Reson. 2010 Nov;207(1):42-52
– reference: 9581599 - Magn Reson Med. 1998 May;39(5):697-701
– reference: 10025608 - Magn Reson Med. 1999 Jan;41(1):30-4
– reference: 16385518 - Arthritis Rheum. 2006 Jan;54(1):226-9
– reference: 17075961 - NMR Biomed. 2006 Nov;19(7):781-821
– reference: 14519880 - Radiology. 2003 Oct;229(1):269-74
– reference: 19934104 - Ann Rheum Dis. 2010 May;69(5):856-61
– reference: 19950287 - Arthritis Rheum. 2009 Dec;60(12):3546-53
– reference: 10617432 - J Magn Reson. 2000 Jan;142(1):24-31
– reference: 12147862 - Radiology. 2002 Aug;224(2):598-602
– reference: 1309384 - J Orthop Res. 1992 Jan;10(1):1-13
– reference: 18590824 - Pharmacol Res. 2008 Jul;58(1):1-7
– reference: 18268341 - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2266-70
– reference: 15844163 - Magn Reson Med. 2005 May;53(5):993-8
– reference: 17969013 - Magn Reson Med. 2007 Dec;58(6):1182-95
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Snippet To assess the potential use of sodium magnetic resonance (MR) imaging of cartilage, with and without fluid suppression by using an adiabatic pulse, for...
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SubjectTerms Adult
Aged
Aged, 80 and over
Area Under Curve
Cartilage, Articular - pathology
Case-Control Studies
Female
Humans
Image Interpretation, Computer-Assisted
Logistic Models
Magnetic Resonance Imaging - methods
Male
Middle Aged
Osteoarthritis, Knee - pathology
Phantoms, Imaging
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
Sodium - metabolism
Title Articular cartilage: evaluation with fluid-suppressed 7.0-T sodium MR imaging in subjects with and subjects without osteoarthritis
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