Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications

The cardiac voltage-gated Na+ channel, NaV1.5, is responsible for the upstroke of the action potential in cardiomyocytes and for efficient propagation of the electrical impulse in the myocardium. Even subtle alterations of NaV1.5 function, as caused by mutations in its gene SCN5A, may lead to many d...

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Veröffentlicht in:	Journal of molecular and cellular cardiology Jg. 82; S. 36 - 47
Hauptverfasser:	Marionneau, Céline, Abriel, Hugues
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.05.2015 Elsevier
Schriftenreihe:	Equipe 1
Schlagworte:	Acetylation Animals Arrhythmias Cardiac NaV1.5 channels Gene Expression Regulation Glycosylation Humans Life Sciences Mass Spectrometry Methylation Native proteomics NAV1.5 Voltage-Gated Sodium Channel - genetics NAV1.5 Voltage-Gated Sodium Channel - metabolism Oxidation-Reduction Phosphorylation Post-translational modifications Protein Processing, Post-Translational Proteomics - methods Ubiquitination Ac BrS pS PKB/Akt pT MS LQTS PKA NaV α subunit PTM Redox PKC pY Cardiac NaV1.5 channels INaL CaMKII Post-translational modifications Native proteomics PI3K SGK Me AMPK INa Arrhythmias Cardiac Na(V)1.5 channels Cardiac Na V 15 channels
ISSN:	0022-2828, 1095-8584, 1095-8584
Online-Zugang:	Volltext
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