Grapevine Shoot Extract Rich in Trans-Resveratrol and Trans-ε-Viniferin: Evaluation of Their Potential Use for Cardiac Health

A grapevine shoot extract (GSE) was obtained using ultrasound-assisted extraction and characterized. The main phenolic constituents were identified as stilbenoids. Among them, trans-resveratrol and trans-ε-viniferin stood out. The GSE was administered to an isoproterenol-induced myocardial injury an...

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Vydáno v:Foods Ročník 12; číslo 23; s. 4351
Hlavní autoři: Contreras, María del Mar, Feriani, Anouar, Gómez-Cruz, Irene, Hfaiedh, Najla, Harrath, Abdel Halim, Romero, Inmaculada, Castro, Eulogio, Tlili, Nizar
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 02.12.2023
Témata:
Angiotensin
Animal models
Antioxidants
Biomass
Biomolecules
cardiac health
Cardiovascular diseases
Cultivars
DNA fragmentation
Ethanol
Glutathione
grapevine
Heart function
Humidity
Ion concentration
Laboratory animals
Lipids
Necrosis
Particle size
Peptidyl-dipeptidase A
Phenolic compounds
Phenols
Resveratrol
shoots
Signs and symptoms
stilbenoids
Sulfur
trans-resveratrol
Ultrasonic imaging
valorization
Wineries & vineyards
France
United States > US
Tunisia
Spain
stilbenoids
valorization
cardiac health
trans-resveratrol
grapevine
shoots
ISSN:2304-8158, 2304-8158
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Shrnutí:A grapevine shoot extract (GSE) was obtained using ultrasound-assisted extraction and characterized. The main phenolic constituents were identified as stilbenoids. Among them, trans-resveratrol and trans-ε-viniferin stood out. The GSE was administered to an isoproterenol-induced myocardial injury animal model. The extract alleviated the associated symptoms of the administration of the drug, i.e., the plasma lipid profile was improved, while the disturbed plasma ion concentration, the cardiac dysfunction markers, the DNA laddering, and the necrosis of myocardial tissue were diminished. This effect could be related to the anti-oxidative potential of GSE associated with its antioxidant properties, the increased levels of endogenous antioxidants (glutathione and enzymatic antioxidants), and the diminished lipid peroxidative markers in the heart. The results also revealed angiotensin-converting enzyme (ACE)-inhibitory activity, which indicated the potential of GSE to deal with cardiovascular disease events. This work suggests that not only trans-resveratrol has a protective role in heart function but also GSE containing this biomolecule and derivatives. Therefore, GSE has the potential to be utilized in the creation of innovative functional ingredients.
Bibliografie:ObjectType-Article-1
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ISSN:2304-8158
2304-8158
DOI:10.3390/foods12234351