Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study

Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003...

Full description

Saved in:
Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 24; no. 4; pp. 844 - 857
Main Authors: Kim, Ki Wook, Kim, Nayoung, Choi, Yonghoon, Kim, Won Seok, Yoon, Hyuk, Shin, Cheol Min, Park, Young Soo, Lee, Dong Ho, Park, Young Suk, Ahn, Sang-Hoon, Park, Do Joong, Kim, Hyung-Ho, Lee, Hye Seung, Kim, Ji-Won, Kim, Jin Won, Lee, Keun-Wook, Chang, Won, Park, Ji Hoon, Lee, Yoon Jin, Lee, Kyoung Ho, Kim, Young Hoon
Format: Journal Article
Language:English
Published: Singapore Springer Singapore 01.07.2021
Springer Nature B.V
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Cancer Research
Female
Gastrectomy - mortality
Gastric cancer
Gastroenterology
Gene Expression - genetics
Humans
Intestine
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging - classification
Oncology
Original Article
p53 Protein
Prognosis
Retrospective Studies
Stomach Neoplasms - classification
Stomach Neoplasms - genetics
Stomach Neoplasms - mortality
Surgical Oncology
Survival
Survival Rate
Tumor suppressor genes
Tumor Suppressor Protein p53 - metabolism
Young Adult
Recurrence
p53 overexpression
Gastric cancer
Survival
Lauren type
ISSN:1436-3291, 1436-3305, 1436-3305
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression. Results Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion ( P  = 0.026) and Early gastric cancer ( P  = 0.044) in intestinal-type GC, and with advanced TNM stage ( P  < 0.001) and Advanced gastric cancer ( P  < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P  = 0.022; OS in diffuse-type: aHR = 1.401 P  = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P  = 0.039). Conclusion p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
ISSN:1436-3291
1436-3305
1436-3305
DOI:10.1007/s10120-021-01163-y