Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study
Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003...
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| Vydáno v: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Ročník 24; číslo 4; s. 844 - 857 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Singapore
Springer Singapore
01.07.2021
Springer Nature B.V |
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| ISSN: | 1436-3291, 1436-3305, 1436-3305 |
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| Abstract | Background
Inactivation of
TP53
, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.
Methods
From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.
Results
Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (
P
= 0.026) and Early gastric cancer (
P
= 0.044) in intestinal-type GC, and with advanced TNM stage (
P
< 0.001) and Advanced gastric cancer (
P
< 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423,
P
= 0.022; OS in diffuse-type: aHR = 1.401
P
= 0.035; cancer recurrence in diffuse-type: aHR = 1.502,
P
= 0.039).
Conclusion
p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. |
|---|---|
| AbstractList | BackgroundInactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.MethodsFrom May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.ResultsAmong 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039).Conclusionp53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression. Results Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion ( P = 0.026) and Early gastric cancer ( P = 0.044) in intestinal-type GC, and with advanced TNM stage ( P < 0.001) and Advanced gastric cancer ( P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039). Conclusion p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. Inactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression. Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039). p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. Inactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.BACKGROUNDInactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.METHODSFrom May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039).RESULTSAmong 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039).p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC.CONCLUSIONp53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. |
| Author | Kim, Ki Wook Kim, Hyung-Ho Park, Young Suk Kim, Ji-Won Chang, Won Lee, Dong Ho Park, Young Soo Lee, Hye Seung Lee, Yoon Jin Kim, Young Hoon Yoon, Hyuk Shin, Cheol Min Kim, Nayoung Park, Do Joong Lee, Kyoung Ho Ahn, Sang-Hoon Park, Ji Hoon Kim, Jin Won Choi, Yonghoon Kim, Won Seok Lee, Keun-Wook |
| Author_xml | – sequence: 1 givenname: Ki Wook surname: Kim fullname: Kim, Ki Wook organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 2 givenname: Nayoung orcidid: 0000-0002-9397-0406 surname: Kim fullname: Kim, Nayoung email: nakim49@snu.ac.kr organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine – sequence: 3 givenname: Yonghoon surname: Choi fullname: Choi, Yonghoon organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 4 givenname: Won Seok surname: Kim fullname: Kim, Won Seok organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 5 givenname: Hyuk surname: Yoon fullname: Yoon, Hyuk organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 6 givenname: Cheol Min surname: Shin fullname: Shin, Cheol Min organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 7 givenname: Young Soo surname: Park fullname: Park, Young Soo organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 8 givenname: Dong Ho surname: Lee fullname: Lee, Dong Ho organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine – sequence: 9 givenname: Young Suk surname: Park fullname: Park, Young Suk organization: Department of Surgery, Seoul National University Bundang Hospital – sequence: 10 givenname: Sang-Hoon surname: Ahn fullname: Ahn, Sang-Hoon organization: Department of Surgery, Seoul National University Bundang Hospital – sequence: 11 givenname: Do Joong surname: Park fullname: Park, Do Joong organization: Department of Surgery, Seoul National University College of Medicine – sequence: 12 givenname: Hyung-Ho surname: Kim fullname: Kim, Hyung-Ho organization: Department of Surgery, Seoul National University Bundang Hospital, Department of Surgery, Seoul National University College of Medicine – sequence: 13 givenname: Hye Seung surname: Lee fullname: Lee, Hye Seung organization: Department of Pathology, Seoul National University College of Medicine – sequence: 14 givenname: Ji-Won surname: Kim fullname: Kim, Ji-Won organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 15 givenname: Jin Won surname: Kim fullname: Kim, Jin Won organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 16 givenname: Keun-Wook surname: Lee fullname: Lee, Keun-Wook organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine – sequence: 17 givenname: Won surname: Chang fullname: Chang, Won organization: Department of Radiology, Seoul National University Bundang Hospital – sequence: 18 givenname: Ji Hoon surname: Park fullname: Park, Ji Hoon organization: Department of Radiology, Seoul National University Bundang Hospital, Department of Radiology, Seoul National University College of Medicine – sequence: 19 givenname: Yoon Jin surname: Lee fullname: Lee, Yoon Jin organization: Department of Radiology, Seoul National University Bundang Hospital – sequence: 20 givenname: Kyoung Ho surname: Lee fullname: Lee, Kyoung Ho organization: Department of Radiology, Seoul National University Bundang Hospital, Department of Radiology, Seoul National University College of Medicine – sequence: 21 givenname: Young Hoon surname: Kim fullname: Kim, Young Hoon organization: Department of Radiology, Seoul National University Bundang Hospital, Department of Radiology, Seoul National University College of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33598811$$D View this record in MEDLINE/PubMed |
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| Copyright | The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2021 The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2021. |
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| SSID | ssj0015916 |
| Score | 2.4222634 |
| Snippet | Background
Inactivation of
TP53
, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The... Inactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study... BackgroundInactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 844 |
| SubjectTerms | Abdominal Surgery Adult Aged Aged, 80 and over Cancer Research Female Gastrectomy - mortality Gastric cancer Gastroenterology Gene Expression - genetics Humans Intestine Male Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplasm Staging - classification Oncology Original Article p53 Protein Prognosis Retrospective Studies Stomach Neoplasms - classification Stomach Neoplasms - genetics Stomach Neoplasms - mortality Surgical Oncology Survival Survival Rate Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Young Adult |
| Title | Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study |
| URI | https://link.springer.com/article/10.1007/s10120-021-01163-y https://www.ncbi.nlm.nih.gov/pubmed/33598811 https://www.proquest.com/docview/2541346957 https://www.proquest.com/docview/2491064883 |
| Volume | 24 |
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