Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study
Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003...
Uloženo v:
| Vydáno v: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Ročník 24; číslo 4; s. 844 - 857 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Singapore
Springer Singapore
01.07.2021
Springer Nature B.V |
| Témata: | |
| ISSN: | 1436-3291, 1436-3305, 1436-3305 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Background
Inactivation of
TP53
, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.
Methods
From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.
Results
Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (
P
= 0.026) and Early gastric cancer (
P
= 0.044) in intestinal-type GC, and with advanced TNM stage (
P
< 0.001) and Advanced gastric cancer (
P
< 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423,
P
= 0.022; OS in diffuse-type: aHR = 1.401
P
= 0.035; cancer recurrence in diffuse-type: aHR = 1.502,
P
= 0.039).
Conclusion
p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. |
|---|---|
| AbstractList | Background
Inactivation of
TP53
, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.
Methods
From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.
Results
Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (
P
= 0.026) and Early gastric cancer (
P
= 0.044) in intestinal-type GC, and with advanced TNM stage (
P
< 0.001) and Advanced gastric cancer (
P
< 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423,
P
= 0.022; OS in diffuse-type: aHR = 1.401
P
= 0.035; cancer recurrence in diffuse-type: aHR = 1.502,
P
= 0.039).
Conclusion
p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. Inactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression. Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039). p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. BackgroundInactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.MethodsFrom May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.ResultsAmong 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039).Conclusionp53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. Inactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.BACKGROUNDInactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs.From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.METHODSFrom May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression.Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039).RESULTSAmong 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion (P = 0.026) and Early gastric cancer (P = 0.044) in intestinal-type GC, and with advanced TNM stage (P < 0.001) and Advanced gastric cancer (P < 0.001) in diffuse-type GC. The overall survival (OS) and GC-specific survival (GCSS) were significantly lower in p53 overexpression positive patients. This significance was more pronounced and enhanced in the diffuse-type GC and was absent in the intestinal-type GC. In multivariate analyses, p53 overexpression was associated with poor OS in both subtypes of GC and cancer recurrence in diffuse-type GC. (OS in intestinal-type: adjusted hazard ratio [aHR] = 1.423, P = 0.022; OS in diffuse-type: aHR = 1.401 P = 0.035; cancer recurrence in diffuse-type: aHR = 1.502, P = 0.039).p53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC.CONCLUSIONp53 overexpression was associated with poor prognosis in GC, especially in diffuse-type. In addition, p53 overexpression was associated with early stage disease in intestinal-type GC and with advanced stage disease in diffuse-type GC. |
| Author | Kim, Ki Wook Kim, Hyung-Ho Park, Young Suk Kim, Ji-Won Chang, Won Lee, Dong Ho Park, Young Soo Lee, Hye Seung Lee, Yoon Jin Kim, Young Hoon Yoon, Hyuk Shin, Cheol Min Kim, Nayoung Park, Do Joong Lee, Kyoung Ho Ahn, Sang-Hoon Park, Ji Hoon Kim, Jin Won Choi, Yonghoon Kim, Won Seok Lee, Keun-Wook |
| Author_xml | – sequence: 1 givenname: Ki Wook surname: Kim fullname: Kim, Ki Wook organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 2 givenname: Nayoung orcidid: 0000-0002-9397-0406 surname: Kim fullname: Kim, Nayoung email: nakim49@snu.ac.kr organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine – sequence: 3 givenname: Yonghoon surname: Choi fullname: Choi, Yonghoon organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 4 givenname: Won Seok surname: Kim fullname: Kim, Won Seok organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 5 givenname: Hyuk surname: Yoon fullname: Yoon, Hyuk organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 6 givenname: Cheol Min surname: Shin fullname: Shin, Cheol Min organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 7 givenname: Young Soo surname: Park fullname: Park, Young Soo organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 8 givenname: Dong Ho surname: Lee fullname: Lee, Dong Ho organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine – sequence: 9 givenname: Young Suk surname: Park fullname: Park, Young Suk organization: Department of Surgery, Seoul National University Bundang Hospital – sequence: 10 givenname: Sang-Hoon surname: Ahn fullname: Ahn, Sang-Hoon organization: Department of Surgery, Seoul National University Bundang Hospital – sequence: 11 givenname: Do Joong surname: Park fullname: Park, Do Joong organization: Department of Surgery, Seoul National University College of Medicine – sequence: 12 givenname: Hyung-Ho surname: Kim fullname: Kim, Hyung-Ho organization: Department of Surgery, Seoul National University Bundang Hospital, Department of Surgery, Seoul National University College of Medicine – sequence: 13 givenname: Hye Seung surname: Lee fullname: Lee, Hye Seung organization: Department of Pathology, Seoul National University College of Medicine – sequence: 14 givenname: Ji-Won surname: Kim fullname: Kim, Ji-Won organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 15 givenname: Jin Won surname: Kim fullname: Kim, Jin Won organization: Department of Internal Medicine, Seoul National University Bundang Hospital – sequence: 16 givenname: Keun-Wook surname: Lee fullname: Lee, Keun-Wook organization: Department of Internal Medicine, Seoul National University Bundang Hospital, Department of Internal Medicine, Seoul National University College of Medicine – sequence: 17 givenname: Won surname: Chang fullname: Chang, Won organization: Department of Radiology, Seoul National University Bundang Hospital – sequence: 18 givenname: Ji Hoon surname: Park fullname: Park, Ji Hoon organization: Department of Radiology, Seoul National University Bundang Hospital, Department of Radiology, Seoul National University College of Medicine – sequence: 19 givenname: Yoon Jin surname: Lee fullname: Lee, Yoon Jin organization: Department of Radiology, Seoul National University Bundang Hospital – sequence: 20 givenname: Kyoung Ho surname: Lee fullname: Lee, Kyoung Ho organization: Department of Radiology, Seoul National University Bundang Hospital, Department of Radiology, Seoul National University College of Medicine – sequence: 21 givenname: Young Hoon surname: Kim fullname: Kim, Young Hoon organization: Department of Radiology, Seoul National University Bundang Hospital, Department of Radiology, Seoul National University College of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33598811$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kctu1DAUhi3Uil7gBVggS2y6CfiemB0qbUEaqZvuLcdxpq4ydrCdEfM0vCpnOi1IXXTlY53vP7f_DB3FFD1CHyj5TAlpvxRKKCMNYbQhlCre7N6gUyq4ajgn8ug5ZpqeoLNSHgihUlP1Fp1wLnXXUXqK_nwP4-izjxV7CFwtOI14lhzPOVUfIk5bSP-esy8lJPhGXO89Lkvehq2d9vTalpqDw85G5zOebQ1Qr2DrXMpDiGtcE17ZBbrg-1BqmtJ6j08WSo7BAZ_iV2xx9jWnMsMUYQst6jLs3qHj0U7Fv396z9Hd9dXd5Y9mdXvz8_LbqnGCqdr02mkipGQWtpK-J71wolW0H1xn-1Fpwfhgdc_YMMqhJZJqJWjfdVa3blD8HF0cysLWvxZfqtmE4vw02ejTUgwTmhIluo4D-ukF-pCWHGE4w6SgXCgtW6A-PlFLv_GDmXPY2Lwzz5cHgB0AByuX7Md_CCVmb6852GvAXvNor9mBqHshcqE-nq9mG6bXpfwgLdAnrn3-P_Yrqr9hTLzA |
| CitedBy_id | crossref_primary_10_1007_s00261_024_04350_4 crossref_primary_10_3748_wjg_v28_i9_933 crossref_primary_10_1016_j_anndiagpath_2023_152105 crossref_primary_10_1148_radiol_2021211210 crossref_primary_10_1016_j_rineng_2025_104238 crossref_primary_10_1002_ijc_34677 crossref_primary_10_1016_j_prp_2022_154195 crossref_primary_10_1096_fj_202200957RR crossref_primary_10_3233_CBM_230303 crossref_primary_10_1007_s12672_025_02802_x crossref_primary_10_1016_j_asjsur_2024_05_121 crossref_primary_10_1021_acsptsci_4c00677 crossref_primary_10_1186_s40104_021_00653_4 crossref_primary_10_3390_cancers16010054 crossref_primary_10_3390_cancers15102783 crossref_primary_10_7555_JBR_38_20240118 crossref_primary_10_1007_s12094_022_02958_w crossref_primary_10_3390_foods10071630 crossref_primary_10_1111_hel_12929 |
| Cites_doi | 10.1016/j.semcancer.2020.07.005 10.18632/oncotarget.9770 10.1038/bjc.1992.314 10.1038/modpathol.2016.202 10.3748/wjg.15.1381 10.1016/0959-8049(95)00547-1 10.18632/oncotarget.11912 10.1007/s10434-999-0739-3 10.1093/nar/gku1075 10.1038/358015a0 10.1007/s10120-016-0601-9 10.1007/978-1-4020-2922-6_14 10.18632/oncotarget.12291 10.7704/kjhugr.2019.19.2.120 10.1023/A:1018889818855 10.1038/bjc.1998.611 10.1007/s10147-019-01443-9 10.4132/jptm.2020.06.01 10.1016/0016-5085(92)90022-Q 10.1016/j.bpg.2006.03.016 10.1046/j.1440-1827.2001.01216.x 10.1002/(SICI)1097-0142(19970601)79:11<2067::AID-CNCR3>3.0.CO;2-M 10.7314/APJCP.2015.16.1.327 10.1007/s10120-020-01076-2 10.1111/j.1749-6632.2000.tb06705.x 10.1111/j.1349-7006.2004.tb03220.x 10.1038/nm.3850 10.1038/nature13480 10.1111/apm.1965.64.1.31 10.1002/path.1711720104 10.1007/s00432-014-1844-7 10.1126/science.1905840 10.1038/nrc2012 10.1634/theoncologist.2019-0058 10.1111/hel.12542 10.4161/cc.6.9.4211 10.1101/cshperspect.a026179 10.1056/NEJM199507063330107 10.1007/s12253-010-9333-z 10.1038/sj.bjc.6601455 10.4143/crt.2020.206 10.1038/bjc.1993.108 10.1371/journal.pone.0204762 10.4166/kjg.2015.65.4.199 10.1038/bjc.1994.182 10.1186/s12876-020-01354-4 10.1002/1097-0142(19950901)76:5<720::AID-CNCR2820760503>3.0.CO;2-E 10.1002/cam4.346 10.3322/caac.21492 10.1111/cas.12706 10.1111/j.1523-5378.2011.00859.x |
| ContentType | Journal Article |
| Copyright | The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2021 The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2021. |
| Copyright_xml | – notice: The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2021 – notice: The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2021. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 |
| DOI | 10.1007/s10120-021-01163-y |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1436-3305 |
| EndPage | 857 |
| ExternalDocumentID | 33598811 10_1007_s10120_021_01163_y |
| Genre | Evaluation Study Journal Article |
| GrantInformation_xml | – fundername: National Research Foundation of Korea (KR) grantid: No. 2011-0030001 |
| GroupedDBID | --- -5E -5G -BR -EM -Y2 -~C .86 .VR 06C 06D 0R~ 0VY 1N0 1SB 203 29H 29~ 2J2 2JN 2JY 2KG 2LR 2P1 2VQ 2WC 2~H 30V 36B 3V. 4.4 406 408 409 40D 40E 53G 5GY 5VS 67Z 6NX 7X7 88E 8AO 8C1 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABMXE ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHVE ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACZOJ ADBBV ADHHG ADHIR ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BDATZ BENPR BGNMA BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ IMOTQ IWAJR IXC IXD IXE IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KPH LAS LLZTM M1P M4Y MA- N2Q NB0 NPVJJ NQJWS NU0 O9- O93 O9I O9J OAM OK1 P9S PF0 PQQKQ PROAC PSQYO PT4 Q2X QOR QOS R89 R9I ROL RPX RRX RSV S16 S1Z S27 S37 S3B SAP SDH SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 YLTOR Z45 Z7U Z82 Z83 Z87 ZMTXR ZOVNA ~A9 ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c426t-b9c904552a8115eb0b4c4761bdc8abf69423da9b22df5d70519641b88a97cd63 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 28 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000618921500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1436-3291 1436-3305 |
| IngestDate | Thu Sep 04 20:01:28 EDT 2025 Mon Oct 06 18:27:56 EDT 2025 Thu Apr 03 07:06:42 EDT 2025 Tue Nov 18 22:41:14 EST 2025 Sat Nov 29 02:59:41 EST 2025 Fri Feb 21 02:47:22 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Recurrence p53 overexpression Gastric cancer Survival Lauren type |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c426t-b9c904552a8115eb0b4c4761bdc8abf69423da9b22df5d70519641b88a97cd63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
| ORCID | 0000-0002-9397-0406 |
| OpenAccessLink | http://dx.doi.org/10.1007/s10120-021-01163-y |
| PMID | 33598811 |
| PQID | 2541346957 |
| PQPubID | 43697 |
| PageCount | 14 |
| ParticipantIDs | proquest_miscellaneous_2491064883 proquest_journals_2541346957 pubmed_primary_33598811 crossref_primary_10_1007_s10120_021_01163_y crossref_citationtrail_10_1007_s10120_021_01163_y springer_journals_10_1007_s10120_021_01163_y |
| PublicationCentury | 2000 |
| PublicationDate | 2021-07-01 |
| PublicationDateYYYYMMDD | 2021-07-01 |
| PublicationDate_xml | – month: 07 year: 2021 text: 2021-07-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Singapore |
| PublicationPlace_xml | – name: Singapore – name: Japan – name: Tokyo |
| PublicationTitle | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association |
| PublicationTitleAbbrev | Gastric Cancer |
| PublicationTitleAlternate | Gastric Cancer |
| PublicationYear | 2021 |
| Publisher | Springer Singapore Springer Nature B.V |
| Publisher_xml | – name: Springer Singapore – name: Springer Nature B.V |
| References | Gomyo, Ikeda, Osaki, Tatebe, Tsujitani, Ikeguchi (CR27) 1997; 79 Victorzon, Nordling, Haglund, Lundin, Roberts (CR40) 1996; 32A Yildirim, Kaya, Demirpence, Gunduz, Bozcuk (CR41) 2015; 16 Gabbert, Müller, Schneiders, Meier, Hommel (CR28) 1995; 76 Joypaul, Hopwood, Newman, Qureshi, Grant, Ogston (CR25) 1994; 69 Baker, Preisinger, Jessup, Paraskeva, Markowitz, Willson (CR15) 1990; 50 Ranzani, Luinetti, Padovan, Calistri, Renault, Burrel (CR36) 1995; 4 Kakeji, Korenaga, Tsujitani, Baba, Anai, Maehara, Sugimachi (CR24) 1993; 67 Hollstein, Sidransky, Vogelstein, Harris (CR14) 1991; 253 Forbes, Beare, Gunasekaran, Leung, Bindal, Boutselakis (CR11) 2015; 43 Lauren (CR3) 1965; 64 Correa (CR38) 1992; 52 Gonçalves, Carneiro, Martins, de Faria, Ferreira, de Mello (CR29) 2011; 17 Duffy, Synnott, O'Grady, Crown (CR53) 2020 Starzynska, Bromley, Ghosh, Stern (CR23) 1992; 66 Seta, Imazeki, Yokosuka, Saisho, Suzuki, Koide (CR42) 1998; 43 Wei, Jiang, Wei, Wang, Qian, Dai (CR22) 2015; 141 Yoon, Kim, Lee, Shin, Park, Lee (CR57) 2011; 16 Ando, Oki, Saeki, Yan, Tsuda, Hidaka (CR43) 2015; 4 Tahara, Shibata, Okamoto, Yamazaki, Kawamura, Horiguchi (CR55) 2016; 7 Yasui, Oue, Ito, Kuraoka, Nakayama (CR31) 2004; 95 Lim, Kim, Kwon, Kim, Baik, Lee (CR61) 2018; 13 Efeyan, Serrano (CR10) 2007; 6 Koh, Lee, Nam, Seo, Kim, Kim (CR50) 2019; 24 Assumpção, Barra, Ishak, Coelho, Coimbra, Freitas (CR39) 2020; 20 Toledo, Wahl (CR8) 2006; 6 Baas, Mulder, Offerhaus, Vogelstein, Hamilton (CR19) 1994; 172 Lane (CR7) 1992; 358 Kastan, Onyekwere, Sidransky, Vogelstein, Craig (CR12) 1991; 51 Cristescu, Lee, Nebozhyn, Kim, Ting, Wong (CR46) 2015; 21 Murnyák, Hortobágyi (CR44) 2016; 7 Roviello, Marrelli, Vindigni, De Stefano, Spina, Pinto (CR6) 1999; 6 Yun, Kim, Lee, Lee, Hwang, Lee (CR58) 2018; 23 Bray, Ferlay, Soerjomataram, Siegel, Torre, Jemal (CR1) 2018; 68 Fuchs, Mayer (CR4) 1995; 333 Watanabe, Jass, Sobin (CR2) 2012 (CR45) 2014; 513 Hwang, Nam, Park, Park, Koh, Na (CR21) 2020; 54 Imazeki, Omata, Nose, Ohto, Isono (CR16) 1992; 103 Karim, Ali (CR20) 2009; 15 Motojima, Furui, Kohara, Ito, Kanematsu (CR26) 1994; 116 Olivier, Hainaut, Børresen-Dale, Hainaut, Wiman (CR9) 2005 Oue, Sentani, Sakamoto, Uraoka, Yasui (CR49) 2019; 24 Soussi (CR13) 2000; 910 Pietrantonio, De Braud, Da Prat, Perrone, Pierotti, Gariboldi (CR18) 2013; 33 Lee, Shun, Hong, Wu, Chang, Chen (CR34) 1998; 85 Saito, Abe, Kunita, Yamashita, Seto, Fukayama (CR47) 2017; 30 Liu, Tsushimi, Tsushimi, Oga, Kawauchi, Furuya (CR33) 2001; 51 Lee, Kim, Kwon, Lee (CR59) 2019; 19 Greenblatt, Bennett, Hollstein, Harris (CR17) 1994; 54 Park (CR60) 2015; 65 Hainaut, Pfeifer (CR52) 2016; 6 Vauhkonen, Vauhkonen, Sipponen (CR30) 2006; 20 Choi, Kim, Yun, Choi, Yoon, Shin (CR35) 2020; 23 Sano, Coit, Kim, Roviello, Kassab, Wittekind (CR5) 2017; 20 Fondevila, Metges, Fuster, Grau, Palacín, Castells (CR54) 2004; 90 Wu, Shun, Lee, Chen, Wang, Lee (CR37) 1998; 78 Oue, Sentani, Sakamoto, Yasui (CR32) 2015; 106 Tan, Yeoh (CR48) 2015; 149 Park, Park, Kim, Rha, Hyung, Cheong (CR51) 2016; 7 Hong, Won, Park, Jung, Kong, Lee (CR56) 2020; 52 IO Baas (1163_CR19) 1994; 172 MB Kastan (1163_CR12) 1991; 51 MJ Duffy (1163_CR53) 2020 S Karim (1163_CR20) 2009; 15 P Correa (1163_CR38) 1992; 52 H Yoon (1163_CR57) 2011; 16 SH Park (1163_CR60) 2015; 65 Y Kakeji (1163_CR24) 1993; 67 T Tahara (1163_CR55) 2016; 7 W Yasui (1163_CR31) 2004; 95 M Vauhkonen (1163_CR30) 2006; 20 Cancer Genome Atlas Research Network (1163_CR45) 2014; 513 F Roviello (1163_CR6) 1999; 6 T Starzynska (1163_CR23) 1992; 66 T Soussi (1163_CR13) 2000; 910 HE Gabbert (1163_CR28) 1995; 76 N Oue (1163_CR49) 2019; 24 HJ Hwang (1163_CR21) 2020; 54 R Saito (1163_CR47) 2017; 30 BV Joypaul (1163_CR25) 1994; 69 AR Gonçalves (1163_CR29) 2011; 17 A Efeyan (1163_CR10) 2007; 6 M Hollstein (1163_CR14) 1991; 253 XP Liu (1163_CR33) 2001; 51 JW Lee (1163_CR59) 2019; 19 WJ Lee (1163_CR34) 1998; 85 GN Ranzani (1163_CR36) 1995; 4 J Koh (1163_CR50) 2019; 24 B Murnyák (1163_CR44) 2016; 7 H Watanabe (1163_CR2) 2012 MS Greenblatt (1163_CR17) 1994; 54 T Sano (1163_CR5) 2017; 20 R Cristescu (1163_CR46) 2015; 21 T Seta (1163_CR42) 1998; 43 P Lauren (1163_CR3) 1965; 64 P Hainaut (1163_CR52) 2016; 6 DP Lane (1163_CR7) 1992; 358 M Victorzon (1163_CR40) 1996; 32A F Toledo (1163_CR8) 2006; 6 M Olivier (1163_CR9) 2005 Y Gomyo (1163_CR27) 1997; 79 S Hong (1163_CR56) 2020; 52 F Imazeki (1163_CR16) 1992; 103 MS Wu (1163_CR37) 1998; 78 SH Lim (1163_CR61) 2018; 13 SA Forbes (1163_CR11) 2015; 43 K Wei (1163_CR22) 2015; 141 K Ando (1163_CR43) 2015; 4 PP Assumpção (1163_CR39) 2020; 20 P Tan (1163_CR48) 2015; 149 N Oue (1163_CR32) 2015; 106 F Pietrantonio (1163_CR18) 2013; 33 C Fondevila (1163_CR54) 2004; 90 K Motojima (1163_CR26) 1994; 116 SJ Baker (1163_CR15) 1990; 50 CS Fuchs (1163_CR4) 1995; 333 CY Yun (1163_CR58) 2018; 23 CK Park (1163_CR51) 2016; 7 F Bray (1163_CR1) 2018; 68 M Yildirim (1163_CR41) 2015; 16 Y Choi (1163_CR35) 2020; 23 |
| References_xml | – start-page: 321 year: 2005 end-page: 338 ident: CR9 article-title: Prognostic and predictive value of mutations in human cancer publication-title: 25 years of p53 research – volume: 90 start-page: 206 year: 2004 end-page: 215 ident: CR54 article-title: p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer publication-title: Br J Cancer – volume: 33 start-page: 1257 year: 2013 end-page: 1266 ident: CR18 article-title: A review on biomarkers for prediction of treatment outcome in gastric cancer publication-title: Anticancer Res – volume: 68 start-page: 394 year: 2018 end-page: 424 ident: CR1 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin – volume: 15 start-page: 1381 year: 2009 end-page: 1387 ident: CR20 article-title: Correlation of p53 over-expression and alteration in p53 gene detected by polymerase chain reaction-single strand conformation polymorphism in adenocarcinoma of gastric cancer patients from India publication-title: World J Gastroenterol – volume: 20 start-page: 651 year: 2006 end-page: 674 ident: CR30 article-title: Pathology and molecular biology of gastric cancer publication-title: Best Pract Res Clin Gastroenterol – volume: 149 start-page: e3 issue: 1153–1162 year: 2015 ident: CR48 article-title: Genetics and molecular pathogenesis of gastric adenocarcinoma publication-title: Gastroenterology – volume: 65 start-page: 199 year: 2015 end-page: 204 ident: CR60 article-title: Changes in upper gastrointestinal diseases according to improvement of prevalence rate in Korea publication-title: Korean J Gastroenterol – year: 2012 ident: CR2 publication-title: Histological typing of oesophageal and gastric tumours: in collaboration with pathologists in 8 countries – volume: 17 start-page: 349 year: 2011 end-page: 355 ident: CR29 article-title: Prognostic significance of p53 protein expression in early gastric cancer publication-title: Pathol Oncol Res – volume: 7 start-page: 72099 year: 2016 end-page: 72112 ident: CR51 article-title: Receptor tyrosine kinase amplified gastric cancer: clinicopathologic characteristics and proposed screening algorithm publication-title: Oncotarget – volume: 6 start-page: 739 issue: 8 year: 1999 end-page: 745 ident: CR6 article-title: P53 accumulation is a prognostic factor in intestinal-type gastric carcinoma but not in the diffuse type publication-title: Ann Surg Oncol – volume: 50 start-page: 7717 year: 1990 end-page: 7722 ident: CR15 article-title: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis publication-title: Cancer Res – volume: 333 start-page: 32 year: 1995 end-page: 41 ident: CR4 article-title: Gastric carcinoma publication-title: N Engl J Med – volume: 6 start-page: a026179 year: 2016 ident: CR52 article-title: Somatic mutations in the era of genome sequencing publication-title: Cold Spring Harb Perspect Med – volume: 16 start-page: 382 year: 2011 end-page: 388 ident: CR57 article-title: -negative gastric cancer in South Korea: incidence and clinicopathologic characteristics publication-title: Helicobacter – volume: 76 start-page: 720 year: 1995 end-page: 726 ident: CR28 article-title: The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma publication-title: Cancer – volume: 103 start-page: 892 year: 1992 end-page: 896 ident: CR16 article-title: p53 gene mutations in gastric and esophageal cancers publication-title: Gastroenterology – volume: 7 start-page: 42252 year: 2016 end-page: 42260 ident: CR55 article-title: Mutation spectrum of gene predicts clinicopathological features and survival of gastric cancer publication-title: Oncotarget – volume: 52 start-page: 6735 year: 1992 end-page: 6740 ident: CR38 article-title: Human gastric carcinogenesis: a multistep and multifactorial process–first American Cancer Society Award Lecture on Cancer Epidemiology and Prevention publication-title: Cancer Res – volume: 253 start-page: 49 year: 1991 end-page: 53 ident: CR14 article-title: p53 mutations in human cancers publication-title: Science – volume: 43 start-page: 279 year: 1998 end-page: 289 ident: CR42 article-title: Expression of p53 and p21WAF1/CIP1 proteins in gastric and esophageal cancers: comparison with mutations of the p53 gene publication-title: Dig Dis Sci – volume: 20 start-page: 217 year: 2017 end-page: 225 ident: CR5 article-title: Proposal of a new stage grouping of gastric cancer for TNM classification: International Gastric Cancer Association staging project publication-title: Gastric Cancer – volume: 19 start-page: 120 year: 2019 end-page: 126 ident: CR59 article-title: Changes in the clinical and pathological characteristics of gastric cancer during the last 16 years: A study of a single institution in Korea publication-title: Korean J Helicobacter Up Gastrointest Res – volume: 78 start-page: 971 year: 1998 end-page: 973 ident: CR37 article-title: Overexpression of p53 in different subtypes of intestinal metaplasia and gastric cancer publication-title: Br J Cancer – volume: 13 start-page: e0204762 year: 2018 ident: CR61 article-title: Trends in the seroprevalence of infection and its putative eradication rate over 18 years in Korea: a cross-sectional nationwide multicenter study publication-title: PLoS ONE – volume: 52 start-page: 335 year: 2020 end-page: 350 ident: CR56 article-title: Community of population-based regional cancer registries. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2017 publication-title: Cancer Res Treat. – volume: 24 start-page: 771 year: 2019 end-page: 778 ident: CR49 article-title: Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells publication-title: Int J Clin Oncol – volume: 172 start-page: 5 year: 1994 end-page: 12 ident: CR19 article-title: An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms publication-title: J Pathol – volume: 54 start-page: 378 year: 2020 end-page: 386 ident: CR21 article-title: Prediction of mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer publication-title: J Pathol Transl Med – volume: 116 start-page: 890 year: 1994 end-page: 895 ident: CR26 article-title: Expression of p53 protein in gastric carcinomas is not independently prognostic publication-title: Surgery – volume: 4 start-page: 75 year: 2015 end-page: 83 ident: CR43 article-title: Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer publication-title: Cancer Med – year: 2020 ident: CR53 article-title: Targeting p53 for the treatment of cancer publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2020.07.005 – volume: 51 start-page: 6304 year: 1991 end-page: 6311 ident: CR12 article-title: Participation of p53 protein in the cellular response to DNA damage publication-title: Cancer Res – volume: 85 start-page: 1138 year: 1998 end-page: 1142 ident: CR34 article-title: Overexpression of p53 predicts shorter survival in diffuse type gastric cancer publication-title: Br J Surg – volume: 51 start-page: 440 year: 2001 end-page: 444 ident: CR33 article-title: Expression of p53 protein as a prognostic indicator of reduced survival time in diffuse-type gastric carcinoma publication-title: Pathol Int – volume: 79 start-page: 2067 year: 1997 end-page: 2072 ident: CR27 article-title: Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma publication-title: Cancer – volume: 20 start-page: 223 year: 2020 ident: CR39 article-title: The diffuse-type gastric cancer epidemiology enigma publication-title: BMC Gastroenterol – volume: 7 start-page: 64910 year: 2016 end-page: 64920 ident: CR44 article-title: Immunohistochemical correlates of somatic mutations in cancer publication-title: Oncotarget – volume: 21 start-page: 449 year: 2015 end-page: 456 ident: CR46 article-title: Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes publication-title: Nat Med – volume: 43 start-page: D805 issue: Database issue year: 2015 end-page: D811 ident: CR11 article-title: COSMIC: exploring the world's knowledge of somatic mutations in human cancer publication-title: Nucleic Acids Res. – volume: 513 start-page: 202 year: 2014 end-page: 209 ident: CR45 article-title: Comprehensive molecular characterization of gastric adenocarcinoma publication-title: Nature – volume: 95 start-page: 385 year: 2004 end-page: 392 ident: CR31 article-title: Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications publication-title: Cancer Sci – volume: 54 start-page: 4855 year: 1994 end-page: 4878 ident: CR17 article-title: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis publication-title: Cancer Res – volume: 24 start-page: e1321 year: 2019 end-page: e1330 ident: CR50 article-title: Development and validation of an easy-to-implement, practical algorithm for the identification of molecular subtypes of gastric cancer: prognostic and therapeutic implications publication-title: Oncologist – volume: 6 start-page: 909 year: 2006 end-page: 923 ident: CR8 article-title: Regulating the p53 pathway: in vitro hypotheses, in vivo veritas publication-title: Nat Rev Cancer – volume: 106 start-page: 951 year: 2015 end-page: 958 ident: CR32 article-title: Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype publication-title: Cancer Sci – volume: 23 start-page: 1051 year: 2020 end-page: 1063 ident: CR35 article-title: Effect of eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow-up for up to 15 years publication-title: Gastric Cancer – volume: 66 start-page: 558 year: 1992 end-page: 562 ident: CR23 article-title: Prognostic significance of p53 overexpression in gastric and colorectal carcinoma publication-title: Br J Cancer – volume: 69 start-page: 943 year: 1994 end-page: 946 ident: CR25 article-title: The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma publication-title: Br J Cancer – volume: 6 start-page: 1006 year: 2007 end-page: 1010 ident: CR10 article-title: p53: guardian of the genome and policeman of the oncogenes publication-title: Cell Cycle – volume: 910 start-page: 121 year: 2000 end-page: 137 ident: CR13 article-title: The p53 tumor suppressor gene: from molecular biology to clinical investigation publication-title: Ann N Y Acad Sci. – volume: 23 start-page: e12542 year: 2018 ident: CR58 article-title: Usefulness of OLGA and OLGIM system not only for intestinal type but also for diffuse type of gastric cancer, and no interaction among the gastric cancer risk factors publication-title: Helicobacter – volume: 141 start-page: 735 year: 2015 end-page: 748 ident: CR22 article-title: The prognostic significance of p53 expression in gastric cancer: a meta-analysis publication-title: J Cancer Res Clin Oncol – volume: 30 start-page: 427 year: 2017 end-page: 439 ident: CR47 article-title: Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications publication-title: Mod Pathol – volume: 358 start-page: 15 year: 1992 end-page: 16 ident: CR7 article-title: Cancer. p53, guardian of the genome publication-title: Nature – volume: 4 start-page: 223 year: 1995 end-page: 231 ident: CR36 article-title: p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type publication-title: Cancer Epidemiol Biomark Prev – volume: 16 start-page: 327 year: 2015 end-page: 332 ident: CR41 article-title: Prognostic significance of p53 in gastric cancer: a meta- analysis publication-title: Asian Pac J Cancer Prev – volume: 32A start-page: 215 year: 1996 end-page: 220 ident: CR40 article-title: Expression of p53 protein as a prognostic factor in patients with gastric cancer publication-title: Eur J Cancer – volume: 64 start-page: 31 year: 1965 end-page: 49 ident: CR3 article-title: The tow hitological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Anattept at a histo-clinical classification publication-title: Acta Pathol Microbiol Scand. – volume: 67 start-page: 589 year: 1993 end-page: 593 ident: CR24 article-title: Gastric cancer with p53 overexpression has high potential for metastasising to lymph nodes publication-title: Br J Cancer – volume: 54 start-page: 4855 year: 1994 ident: 1163_CR17 publication-title: Cancer Res – volume: 7 start-page: 42252 year: 2016 ident: 1163_CR55 publication-title: Oncotarget doi: 10.18632/oncotarget.9770 – volume: 66 start-page: 558 year: 1992 ident: 1163_CR23 publication-title: Br J Cancer doi: 10.1038/bjc.1992.314 – volume: 30 start-page: 427 year: 2017 ident: 1163_CR47 publication-title: Mod Pathol doi: 10.1038/modpathol.2016.202 – volume: 52 start-page: 6735 year: 1992 ident: 1163_CR38 publication-title: Cancer Res – volume: 15 start-page: 1381 year: 2009 ident: 1163_CR20 publication-title: World J Gastroenterol doi: 10.3748/wjg.15.1381 – volume: 32A start-page: 215 year: 1996 ident: 1163_CR40 publication-title: Eur J Cancer doi: 10.1016/0959-8049(95)00547-1 – volume: 7 start-page: 64910 year: 2016 ident: 1163_CR44 publication-title: Oncotarget doi: 10.18632/oncotarget.11912 – volume: 6 start-page: 739 issue: 8 year: 1999 ident: 1163_CR6 publication-title: Ann Surg Oncol doi: 10.1007/s10434-999-0739-3 – volume: 43 start-page: D805 issue: Database issue year: 2015 ident: 1163_CR11 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1075 – year: 2020 ident: 1163_CR53 publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2020.07.005 – volume: 358 start-page: 15 year: 1992 ident: 1163_CR7 publication-title: Nature doi: 10.1038/358015a0 – volume: 20 start-page: 217 year: 2017 ident: 1163_CR5 publication-title: Gastric Cancer doi: 10.1007/s10120-016-0601-9 – start-page: 321 volume-title: 25 years of p53 research year: 2005 ident: 1163_CR9 doi: 10.1007/978-1-4020-2922-6_14 – volume: 7 start-page: 72099 year: 2016 ident: 1163_CR51 publication-title: Oncotarget doi: 10.18632/oncotarget.12291 – volume: 19 start-page: 120 year: 2019 ident: 1163_CR59 publication-title: Korean J Helicobacter Up Gastrointest Res doi: 10.7704/kjhugr.2019.19.2.120 – volume: 43 start-page: 279 year: 1998 ident: 1163_CR42 publication-title: Dig Dis Sci doi: 10.1023/A:1018889818855 – volume: 78 start-page: 971 year: 1998 ident: 1163_CR37 publication-title: Br J Cancer doi: 10.1038/bjc.1998.611 – volume: 24 start-page: 771 year: 2019 ident: 1163_CR49 publication-title: Int J Clin Oncol doi: 10.1007/s10147-019-01443-9 – volume: 116 start-page: 890 year: 1994 ident: 1163_CR26 publication-title: Surgery – volume: 54 start-page: 378 year: 2020 ident: 1163_CR21 publication-title: J Pathol Transl Med doi: 10.4132/jptm.2020.06.01 – volume: 4 start-page: 223 year: 1995 ident: 1163_CR36 publication-title: Cancer Epidemiol Biomark Prev – volume: 103 start-page: 892 year: 1992 ident: 1163_CR16 publication-title: Gastroenterology doi: 10.1016/0016-5085(92)90022-Q – volume: 20 start-page: 651 year: 2006 ident: 1163_CR30 publication-title: Best Pract Res Clin Gastroenterol doi: 10.1016/j.bpg.2006.03.016 – volume: 51 start-page: 440 year: 2001 ident: 1163_CR33 publication-title: Pathol Int doi: 10.1046/j.1440-1827.2001.01216.x – volume: 79 start-page: 2067 year: 1997 ident: 1163_CR27 publication-title: Cancer doi: 10.1002/(SICI)1097-0142(19970601)79:11<2067::AID-CNCR3>3.0.CO;2-M – volume: 85 start-page: 1138 year: 1998 ident: 1163_CR34 publication-title: Br J Surg – volume: 16 start-page: 327 year: 2015 ident: 1163_CR41 publication-title: Asian Pac J Cancer Prev doi: 10.7314/APJCP.2015.16.1.327 – volume: 51 start-page: 6304 year: 1991 ident: 1163_CR12 publication-title: Cancer Res – volume: 23 start-page: 1051 year: 2020 ident: 1163_CR35 publication-title: Gastric Cancer doi: 10.1007/s10120-020-01076-2 – volume: 910 start-page: 121 year: 2000 ident: 1163_CR13 publication-title: Ann N Y Acad Sci. doi: 10.1111/j.1749-6632.2000.tb06705.x – volume: 95 start-page: 385 year: 2004 ident: 1163_CR31 publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2004.tb03220.x – volume: 21 start-page: 449 year: 2015 ident: 1163_CR46 publication-title: Nat Med doi: 10.1038/nm.3850 – volume: 513 start-page: 202 year: 2014 ident: 1163_CR45 publication-title: Nature doi: 10.1038/nature13480 – volume: 64 start-page: 31 year: 1965 ident: 1163_CR3 publication-title: Acta Pathol Microbiol Scand. doi: 10.1111/apm.1965.64.1.31 – volume: 172 start-page: 5 year: 1994 ident: 1163_CR19 publication-title: J Pathol doi: 10.1002/path.1711720104 – volume: 141 start-page: 735 year: 2015 ident: 1163_CR22 publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-014-1844-7 – volume: 253 start-page: 49 year: 1991 ident: 1163_CR14 publication-title: Science doi: 10.1126/science.1905840 – volume: 6 start-page: 909 year: 2006 ident: 1163_CR8 publication-title: Nat Rev Cancer doi: 10.1038/nrc2012 – volume: 24 start-page: e1321 year: 2019 ident: 1163_CR50 publication-title: Oncologist doi: 10.1634/theoncologist.2019-0058 – volume-title: Histological typing of oesophageal and gastric tumours: in collaboration with pathologists in 8 countries year: 2012 ident: 1163_CR2 – volume: 23 start-page: e12542 year: 2018 ident: 1163_CR58 publication-title: Helicobacter doi: 10.1111/hel.12542 – volume: 6 start-page: 1006 year: 2007 ident: 1163_CR10 publication-title: Cell Cycle doi: 10.4161/cc.6.9.4211 – volume: 6 start-page: a026179 year: 2016 ident: 1163_CR52 publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a026179 – volume: 333 start-page: 32 year: 1995 ident: 1163_CR4 publication-title: N Engl J Med doi: 10.1056/NEJM199507063330107 – volume: 17 start-page: 349 year: 2011 ident: 1163_CR29 publication-title: Pathol Oncol Res doi: 10.1007/s12253-010-9333-z – volume: 90 start-page: 206 year: 2004 ident: 1163_CR54 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6601455 – volume: 52 start-page: 335 year: 2020 ident: 1163_CR56 publication-title: Cancer Res Treat. doi: 10.4143/crt.2020.206 – volume: 33 start-page: 1257 year: 2013 ident: 1163_CR18 publication-title: Anticancer Res – volume: 67 start-page: 589 year: 1993 ident: 1163_CR24 publication-title: Br J Cancer doi: 10.1038/bjc.1993.108 – volume: 13 start-page: e0204762 year: 2018 ident: 1163_CR61 publication-title: PLoS ONE doi: 10.1371/journal.pone.0204762 – volume: 65 start-page: 199 year: 2015 ident: 1163_CR60 publication-title: Korean J Gastroenterol doi: 10.4166/kjg.2015.65.4.199 – volume: 50 start-page: 7717 year: 1990 ident: 1163_CR15 publication-title: Cancer Res – volume: 149 start-page: e3 issue: 1153–1162 year: 2015 ident: 1163_CR48 publication-title: Gastroenterology – volume: 69 start-page: 943 year: 1994 ident: 1163_CR25 publication-title: Br J Cancer doi: 10.1038/bjc.1994.182 – volume: 20 start-page: 223 year: 2020 ident: 1163_CR39 publication-title: BMC Gastroenterol doi: 10.1186/s12876-020-01354-4 – volume: 76 start-page: 720 year: 1995 ident: 1163_CR28 publication-title: Cancer doi: 10.1002/1097-0142(19950901)76:5<720::AID-CNCR2820760503>3.0.CO;2-E – volume: 4 start-page: 75 year: 2015 ident: 1163_CR43 publication-title: Cancer Med doi: 10.1002/cam4.346 – volume: 68 start-page: 394 year: 2018 ident: 1163_CR1 publication-title: CA Cancer J Clin doi: 10.3322/caac.21492 – volume: 106 start-page: 951 year: 2015 ident: 1163_CR32 publication-title: Cancer Sci doi: 10.1111/cas.12706 – volume: 16 start-page: 382 year: 2011 ident: 1163_CR57 publication-title: Helicobacter doi: 10.1111/j.1523-5378.2011.00859.x |
| SSID | ssj0015916 |
| Score | 2.4221804 |
| Snippet | Background
Inactivation of
TP53
, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The... Inactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study... BackgroundInactivation of TP53, a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 844 |
| SubjectTerms | Abdominal Surgery Adult Aged Aged, 80 and over Cancer Research Female Gastrectomy - mortality Gastric cancer Gastroenterology Gene Expression - genetics Humans Intestine Male Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplasm Staging - classification Oncology Original Article p53 Protein Prognosis Retrospective Studies Stomach Neoplasms - classification Stomach Neoplasms - genetics Stomach Neoplasms - mortality Surgical Oncology Survival Survival Rate Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Young Adult |
| Title | Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study |
| URI | https://link.springer.com/article/10.1007/s10120-021-01163-y https://www.ncbi.nlm.nih.gov/pubmed/33598811 https://www.proquest.com/docview/2541346957 https://www.proquest.com/docview/2491064883 |
| Volume | 24 |
| WOSCitedRecordID | wos000618921500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1436-3305 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015916 issn: 1436-3291 databaseCode: RSV dateStart: 19981201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9UwDLbYmBAXYPwsjMlI3KASbdo04YaAiQNMaEzTu1VJmk6TUDu1fdP21_CvYuelb6ANJDhWTdPIdewvtf0Z4GVjWiNV61JXeSbV9i61Spi0tXQUa3JtbPjfcfS52t9Xi4X-GovCxjnbfQ5JBkv9S7FbRkcdTing4IFILzbgJrk7xQ0bDr4drWMHpc5WNUVCpiLXWSyVuX6O393RFYx5JT4a3M7e3f9b8D24E2EmvlvpxTbc8N19uPUlBtIfwI8PsTHKhDGjA_sWT0uBgbjhpENO7fTnMU2WLjskqIjjkkwLKSePPjbc88OhY8UZMDK0jmgcn2hppTj1yHXXvsNAaxzMLDrG65ygFHTiLRoc_DT0c8knBsLbh3C49_Hw_ac09mpIHfn4KbXaaUKHZW4UYUxv39jCFZXMbOOUsa3UBNsao22eN23ZVAwcZZFZpYyuXCPFI9js-s4_ARSlLoQTRWkdcwkK2wqptXXS0FlWNTqBbP5itYs85txO43t9ycDMgq9J8HUQfH2RwKv1M6crFo-_jt6ZFaGOO3qs6eWZKKQuqwRerG_TXuQAi-l8v6QxBYEvSSZRJPB4pUDr1wmmSiTZJPB61pbLyf-8lqf_NvwZ3M6DwnE-8Q5sTsPSP4ctdzadjMMubFQLtRt2y08JnRBY |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB1BQZQL34VAgUHiBpFInDhxb1WhKmK7QrCqeotsx0GVUFIlWUR_DX-1M15nCyogwTGK41iTZ_s5M_MG4GWtGy3Lxsa2cCyq7WxsSqHjxtBRrE6VNv5_x9GsmM_L42P1MSSFDVO0--SS9Cv1T8luCR11OKSAnQciPrsK1zLasVgx_9Pno7XvIFfJKqdIyFikKgmpMr_v49ft6BLHvOQf9dvO_u3_G_AduBVoJu6ucHEXrrj2Htw4DI70-_DjbSiMMmKI6MCuwdNcoBduOGmRQzvd9xAmS5ctElXEYUlLC4GTW3_RXPPDomXg9BgUWgfUlk-0NFIcO-S8a9eilzX2yyxa5uscoOQxsYMaezf23ZTyiV7w9gEs9t8t9g7iUKshtrTHj7FRVhE7zFNdEsd05o3JbFbIxNS21KaRimhbrZVJ07rJ64KJo8wSU5ZaFbaWYgs22q51jwBFrjJhRZYby1qCwjRCKmWs1HSWLWsVQTJ9scoGHXMup_G1ulBgZsNXZPjKG746i-DV-pnTlYrHX1tvT0CowoweKnp5IjKp8iKCF-vbNBfZwaJb1y2pTUbkS9KSKCJ4uALQ-nWCpRLJNhG8ntBy0fmfx_L435o_h82DxeGsmr2ff3gCN1MPPo4t3oaNsV-6p3DdfhtPhv6ZnzPnahESVA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fa9RAEB60SvHF39Vo1RF801CTTTZZ34r1UKxHwVL6FnY3GymU5MjlxP41_qvObDbXlqogPoZMNstkdvebzMw3AK9q3WhZNja2hWNSbWdjUwodN4ZcsTpV2vj_HUf7xXxeHh-rgwtV_D7bfQpJjjUNzNLUDjuLutm5UPiWkNvD6QUcSBDx2XW4kXEiPfvrX4_WcYRcJWN9kZCxSFUSymZ-P8blo-kK3rwSK_VH0OzO_0_-LtwO8BN3R3u5B9dcex82v4QA-wP4uRcapgwYMj2wa3CRC_SEDictcsqn-xHSZ-myRYKQuFzRlkNGy9LfNPcCsWjZoHoMzK1L1JY9XZo1Dh1yPbZr0dMd--0XLeN4TlzytvIONfZu6LupFBQ9Ee5DOJx9OHz_MQ49HGJLZ_8QG2UVocY81SVhT2femsxmhUxMbUttGqkIztVamTStm7wuGFDKLDFlqVVhaym2YKPtWvcYUOQqE1ZkubHMMShMI6RSxkpNPm5ZqwiS6etVNvCbc5uN0-qcmZkVX5HiK6_46iyC1-tnFiO7x1-ltyejqMJKX1b08kRkUuVFBC_Xt2mNcuBFt65bkUxGoEzSVikieDQa0_p1gikUSTcRvJks53zwP8_lyb-Jv4DNg71Ztf9p_vkp3Eq97XHK8TZsDP3KPYOb9vtwsuyf--XzC8skGzg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Different+effects+of+p53+protein+overexpression+on+the+survival+of+gastric+cancer+patients+according+to+Lauren+histologic+classification%3A+a+retrospective+study&rft.jtitle=Gastric+cancer+%3A+official+journal+of+the+International+Gastric+Cancer+Association+and+the+Japanese+Gastric+Cancer+Association&rft.au=Kim%2C+Ki+Wook&rft.au=Kim%2C+Nayoung&rft.au=Choi%2C+Yonghoon&rft.au=Kim%2C+Won+Seok&rft.date=2021-07-01&rft.eissn=1436-3305&rft.volume=24&rft.issue=4&rft.spage=844&rft_id=info:doi/10.1007%2Fs10120-021-01163-y&rft_id=info%3Apmid%2F33598811&rft.externalDocID=33598811 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1436-3291&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1436-3291&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1436-3291&client=summon |